Literature DB >> 3549387

Monoclonal antibodies as probes of the structure and function of insulin receptors.

K Siddle, M A Soos, R M O'Brien, R H Ganderton, R Taylor.   

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Year:  1987        PMID： 3549387     DOI： 10.1042/bst0150047

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


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  8 in total

1.  Negative and positive site-site interactions, and their modulation by pH, insulin analogs, and monoclonal antibodies, are preserved in the purified insulin receptor.

Authors:  C C Wang; I D Goldfine; Y Fujita-Yamaguchi; H G Gattner; D Brandenburg; P De Meyts
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

2.  Constitutive phosphorylation of the receptor for insulinlike growth factor I in cells transformed by the src oncogene.

Authors:  L M Kozma; M J Weber
Journal:  Mol Cell Biol       Date:  1990-07       Impact factor: 4.272

3.  Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain.

Authors:  T Sasaoka; Y Takata; J Kusari; C M Anderson; W J Langlois; J M Olefsky
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-15       Impact factor: 11.205

4.  A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control.

Authors:  Vinay Bhaskar; Ira D Goldfine; Daniel H Bedinger; Angela Lau; Hua F Kuan; Lisa M Gross; Masahisa Handa; Betty A Maddux; Susan R Watson; Shirley Zhu; Ajay J Narasimha; Raphael Levy; Lynn Webster; Sujeewa D Wijesuriya; Naichi Liu; Xiaorong Wu; David Chemla-Vogel; Catarina Tran; Steve R Lee; Steve Wong; Diane Wilcock; Mark L White; John A Corbin
Journal:  Diabetes       Date:  2012-03-08       Impact factor: 9.461

5.  Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models.

Authors:  Gemma V Brierley; Kenneth Siddle; Robert K Semple
Journal:  Diabetologia       Date:  2018-04-27       Impact factor: 10.122

6.  Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity.

Authors:  John A Corbin; Vinay Bhaskar; Ira D Goldfine; Daniel H Bedinger; Angela Lau; Kristen Michelson; Lisa M Gross; Betty A Maddux; Hua F Kuan; Catarina Tran; Llewelyn Lao; Masahisa Handa; Susan R Watson; Ajay J Narasimha; Shirley Zhu; Raphael Levy; Lynn Webster; Sujeewa D Wijesuriya; Naichi Liu; Xiaorong Wu; David Chemla-Vogel; Steve R Lee; Steve Wong; Diane Wilcock; Mark L White
Journal:  PLoS One       Date:  2014-02-12       Impact factor: 3.240

7.  Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia.

Authors:  John A Corbin; Vinay Bhaskar; Ira D Goldfine; Hassan Issafras; Daniel H Bedinger; Angela Lau; Kristen Michelson; Lisa M Gross; Betty A Maddux; Hua F Kuan; Catarina Tran; Llewelyn Lao; Masahisa Handa; Susan R Watson; Ajay J Narasimha; Shirley Zhu; Raphael Levy; Lynn Webster; Sujeewa D Wijesuriya; Naichi Liu; Xiaorong Wu; David Chemla-Vogel; Steve R Lee; Steve Wong; Diane Wilcock; Paul Rubin; Mark L White
Journal:  MAbs       Date:  2014 Jan-Feb       Impact factor: 5.857

8.  Anti-Insulin Receptor Antibodies Improve Hyperglycemia in a Mouse Model of Human Insulin Receptoropathy.

Authors:  Gemma V Brierley; Hannah Webber; Eerika Rasijeff; Sarah Grocott; Kenneth Siddle; Robert K Semple
Journal:  Diabetes       Date:  2020-08-17       Impact factor: 9.461
  8 in total

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