Literature DB >> 3549350

Insulin-like effect of dichloroacetic acid on hexose transport in Swiss 3T3 cells.

K Kitagawa, H Nishino, A Iwashima.   

Abstract

Hexose transport in Swiss 3T3 cells was increased by treatment with dichloroacetic acid as well as by treatment with insulin. Neither extra- nor intracellular Ca2+ was found to be involved in their stimulatory action. On the other hand, the removal of intracellular Mg2+ resulted in a loss of the stimulation. These results suggest that dichloroacetic acid stimulates the hexose transport in Mg2+-dependent manner, similar to that of insulin.

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Year:  1987        PMID： 3549350     DOI： 10.1007/BF01945569

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  Effects of epinephrine and insulin on phosphopeptide metabolism in adipocytes.

Authors:  J Avruch; G R Leone; D B Martin
Journal:  J Biol Chem       Date:  1976-03-10       Impact factor: 5.157

2.  Regulation by lipolytic and antillipolytic compounds of the phosphorylation of specific proteins in isolated intact fat cells.

Authors:  J Forn; P Greengard
Journal:  Arch Biochem Biophys       Date:  1976-10       Impact factor: 4.013

3.  Regulation of lipogenesis in adipose tissue: the significance of the activation of pyruvate dehydrogenase by insulin.

Authors:  S I Taylor; R L Jungas
Journal:  Arch Biochem Biophys       Date:  1974-09       Impact factor: 4.013

4.  Effect of tunicamycin on hexose transport in mouse embryo fibroblast Swiss 3T3 cells.

Authors:  K Kitagawa; H Nishino; A Iwashima
Journal:  Biochim Biophys Acta       Date:  1985-11-21

5.  Effects of divalent cations on the regulation of insulin-sensitive glucose transport and cAMP phosphodiesterase in adipocytes. Insulin-like effects of divalent cations.

Authors:  M Ueda; F W Robinson; M M Smith; T Kono
Journal:  J Biol Chem       Date:  1984-08-10       Impact factor: 5.157

6.  Stimulation of sugar transport in rat soleus muscle by prolonged cooling at 0 degrees C.

Authors:  K T Yu; M K Gould
Journal:  Diabetologia       Date:  1981-11       Impact factor: 10.122

7.  The effect of dichloroacetate on the phosphorylation of mitochondria proteins.

Authors:  J Yang; R A Smith
Journal:  Biochem Biophys Res Commun       Date:  1983-03-29       Impact factor: 3.575

8.  Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids.

Authors:  S Whitehouse; R H Cooper; P J Randle
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857

9.  Mechanism of insulin action on membrane protein recycling: a selective decrease in the phosphorylation state of insulin-like growth factor II receptors in the cell surface membrane.

Authors:  S Corvera; M P Czech
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

10.  Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.

Authors:  K Suzuki; T Kono
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205
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