Lena Yao1, Lili Liu2,3, Ming Dong3, Jinmei Yang2,3, Zhiqiang Zhao2,3, Jiabin Chen3, Lijuan Lv4, Zhaoxia Wu5, Jin Wang6, Xin Sun6, Steven Self7, Parveen Bhatti8,9,10. 1. Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 2. Department of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, Guangdong, China. 3. Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention, Guangzhou, China. 4. Guangdong Maternal and Child Hospital, Guangzhou, China. 5. Nanhai Maternity and Child Healthcare Hospital of Foshan, Foshan, China. 6. National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China. 7. Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA. 8. Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. pbhatti@bccrc.ca. 9. Cancer Control Research, BC Cancer Research Institute, Vancouver, BC, Canada. pbhatti@bccrc.ca. 10. School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. pbhatti@bccrc.ca.
Abstract
BACKGROUND: There has been limited research considering the effects of prenatal exposure to multiple heavy metals on early childhood size and growth. OBJECTIVE: We evaluated prenatal exposures to 15 heavy metals in association with measures of weight, length, and head circumference (HC) measured at birth, and 1, 3 and 6 months of age in a study of 358 mother-child pairs. METHODS: Urinary concentrations were measured in the first and third trimesters of pregnancy and examined, using sex-stratified general linear models, in association with average standardized size and changes in size (growth) over the first 6 months of life. Confounding effects among metals were explored. RESULTS: Increased first trimester Hg and V were associated with decreased average HC among males and weight among females, respectively. Increased first trimester V was associated with a decline in weight among females over time. Increased third trimester Cs, Rb and Tl were associated with increased average weight and HC among males. Increased third trimester Se was associated with increased HC among females over time. Evidence for confounding was observed between Cs, Rb and Tl in association with weight and HC. SIGNIFICANCE: We observed multiple biologically plausible associations between prenatal heavy metal exposures and postnatal size and growth. IMPACT: We have taken a comprehensive and novel approach to evaluating the impacts of prenatal heavy metal exposures on size and growth during early childhood. Our detailed analyses consider exposures to 15 different heavy metals at two time points during pregnancy, as well as multiple metrics of size and growth collected at birth and 1, 3 and 6 months of age.
BACKGROUND: There has been limited research considering the effects of prenatal exposure to multiple heavy metals on early childhood size and growth. OBJECTIVE: We evaluated prenatal exposures to 15 heavy metals in association with measures of weight, length, and head circumference (HC) measured at birth, and 1, 3 and 6 months of age in a study of 358 mother-child pairs. METHODS: Urinary concentrations were measured in the first and third trimesters of pregnancy and examined, using sex-stratified general linear models, in association with average standardized size and changes in size (growth) over the first 6 months of life. Confounding effects among metals were explored. RESULTS: Increased first trimester Hg and V were associated with decreased average HC among males and weight among females, respectively. Increased first trimester V was associated with a decline in weight among females over time. Increased third trimester Cs, Rb and Tl were associated with increased average weight and HC among males. Increased third trimester Se was associated with increased HC among females over time. Evidence for confounding was observed between Cs, Rb and Tl in association with weight and HC. SIGNIFICANCE: We observed multiple biologically plausible associations between prenatal heavy metal exposures and postnatal size and growth. IMPACT: We have taken a comprehensive and novel approach to evaluating the impacts of prenatal heavy metal exposures on size and growth during early childhood. Our detailed analyses consider exposures to 15 different heavy metals at two time points during pregnancy, as well as multiple metrics of size and growth collected at birth and 1, 3 and 6 months of age.
Authors: Jessica E Laine; Kathryn A Bailey; Marisela Rubio-Andrade; Andrew F Olshan; Lisa Smeester; Zuzana Drobná; Amy H Herring; Miroslav Stýblo; Gonzalo G García-Vargas; Rebecca C Fry Journal: Environ Health Perspect Date: 2014-10-17 Impact factor: 9.031
Authors: Yiwen Luo; Lauren E McCullough; Jung-Ying Tzeng; Thomas Darrah; Avner Vengosh; Rachel L Maguire; Arnab Maity; Carmen Samuel-Hodge; Susan K Murphy; Michelle A Mendez; Cathrine Hoyo Journal: BMC Public Health Date: 2017-04-24 Impact factor: 3.295