Literature DB >> 35486090

Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic.

Isabelle Meyts1.   

Abstract

In this issue of JEM, Bastard et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220028) show that a loss-of-function IFNAR1 allele is common in western Polynesians, while Duncan et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212427) report that a loss-of-function IFNAR2 allele is common in Inuits. Homozygotes lack type I IFN immunity but are selectively vulnerable to influenza, COVID-19 pneumonia, and complications of live-attenuated viral vaccines.
© 2022 Meyts.

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Year:  2022        PMID： 35486090      PMCID： PMC9070088          DOI： 10.1084/jem.20220491

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   17.579


  8 in total

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Review 2.  Human Immunology through the Lens of Evolutionary Genetics.

Authors:  Lluis Quintana-Murci
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Journal:  J Clin Immunol       Date:  2022-05-09       Impact factor: 8.542

4.  Human IFNAR2 deficiency: Lessons for antiviral immunity.

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Journal:  Sci Transl Med       Date:  2015-09-30       Impact factor: 17.956

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Authors:  Florian Gothe; Catherine F Hatton; Linh Truong; Zofia Klimova; Veronika Kanderova; Martina Fejtkova; Angela Grainger; Venetia Bigley; Joanna Perthen; Dipayan Mitra; Ales Janda; Eva Fronkova; Dusana Moravcikova; Sophie Hambleton; Christopher J A Duncan
Journal:  Clin Infect Dis       Date:  2022-01-07       Impact factor: 20.999

6.  A Case of Autosomal Recessive Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency with Severe COVID-19.

Authors:  Shaghayegh Khanmohammadi; Nima Rezaei; Mehdi Khazaei; Afshin Shirkani
Journal:  J Clin Immunol       Date:  2021-10-28       Impact factor: 8.317

7.  Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic.

Authors:  Christopher J A Duncan; Morten K Skouboe; Sophie Howarth; Sophie Hambleton; Trine H Mogensen; Anne K Hollensen; Rui Chen; Malene L Børresen; Benjamin J Thompson; Jarmila Stremenova Spegarova; Catherine F Hatton; Frederik F Stæger; Mette K Andersen; John Whittaker; Søren R Paludan; Sofie E Jørgensen; Martin K Thomsen; Jacob G Mikkelsen; Carsten Heilmann; Daniela Buhas; Nina F Øbro; Jakob T Bay; Hanne V Marquart; M Teresa de la Morena; Joseph A Klejka; Matthew Hirschfeld; Line Borgwardt; Isabel Forss; Tania Masmas; Anja Poulsen; Francisco Noya; Guy Rouleau; Torben Hansen; Sirui Zhou; Anders Albrechtsen; Reza Alizadehfar; Eric J Allenspach
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8.  Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome.

Authors:  Alexandra Y Kreins; Michael J Ciancanelli; Satoshi Okada; Xiao-Fei Kong; Noé Ramírez-Alejo; Sara Sebnem Kilic; Jamila El Baghdadi; Shigeaki Nonoyama; Seyed Alireza Mahdaviani; Fatima Ailal; Aziz Bousfiha; Davood Mansouri; Elma Nievas; Cindy S Ma; Geetha Rao; Andrea Bernasconi; Hye Sun Kuehn; Julie Niemela; Jennifer Stoddard; Paul Deveau; Aurelie Cobat; Safa El Azbaoui; Ayoub Sabri; Che Kang Lim; Mikael Sundin; Danielle T Avery; Rabih Halwani; Audrey V Grant; Bertrand Boisson; Dusan Bogunovic; Yuval Itan; Marcela Moncada-Velez; Ruben Martinez-Barricarte; Melanie Migaud; Caroline Deswarte; Laia Alsina; Daniel Kotlarz; Christoph Klein; Ingrid Muller-Fleckenstein; Bernhard Fleckenstein; Valerie Cormier-Daire; Stefan Rose-John; Capucine Picard; Lennart Hammarstrom; Anne Puel; Saleh Al-Muhsen; Laurent Abel; Damien Chaussabel; Sergio D Rosenzweig; Yoshiyuki Minegishi; Stuart G Tangye; Jacinta Bustamante; Jean-Laurent Casanova; Stéphanie Boisson-Dupuis
Journal:  J Exp Med       Date:  2015-08-24       Impact factor: 14.307
  8 in total

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