To the editor,We would like to share ideas on the article “Antibody response to the messenger RNA‐1273 vaccine (Moderna) in liver transplant recipients.”[
] Most liver transplant recipients generate an immune response to the Moderna severe acute respiratory syndrome coronavirus 2 messenger RNA‐based vaccine, and a limited serologic response is predicted by an immunosuppressive regimen that includes mycophenolate.[
] We agree that the immunologic response to the corona virus disease 2019 (COVID‐19) vaccine may differ from that of a healthy person. Immunosuppressive medication may have an impact on vaccination immunologic response. However, we should be aware of the potential impact of asymptomatic COVID‐19. Asymptomatic infection is not rare,[
] and it must be ruled out in any investigation of the novel COVID‐19 vaccine's efficacy. The immunologic response reported in the current investigation by Cuadrado et al.[
] could be influenced by asymptomatic infection before and after immunization.
Authors: Antonio Cuadrado; María Del Barrio; José Ignacio Fortea; Lidia Amigo; David San Segundo; María Paz Rodriguez-Cundin; María Henar Rebollo; Roberto Fernandez-Santiago; Federico Castillo; Maria Achalandabaso; Juan Echeverri; Edward J Anderson; Juan Carlos Rodríguez-Sanjuan; Marcos López-Hoyos; Javier Crespo; Emilio Fábrega Journal: Hepatol Commun Date: 2022-03-28