One-pot multicomponent green LED photoinduced synthesis of chromeno[4,3-b]chromenes catalyzed by a new nanophotocatalyst histaminium tetrachlorozincate.

Histaminium tetrachlorozincate nanoparticles are prepared, characterized and applied as an effective and recoverable photocatalyst in the one-pot, green and multi-component synthesis of various chromenes by the reaction of dimedone and/or 1,3-cyclohexanedione, arylaldehyde and 4-hydroxycoumarin in high yields under solventless conditions at ambient temperature. This new catalyst is characterized by FT-IR, XRD, EDX, NMR, SEM and TEM techniques. The incorporation of histaminium ions into the framework of ZnCl4 2- significantly affected the photocatalytic activity of tetrachlorozincate such that good reusability and recyclability are attained. Moreover, reactive species such as ˙O2 - and hydroxyl radicals have proved to be active species in the presented photocatalytic reaction. In addition, the hot filtration test confirms enough stability of the photocatalyst and no significant leaching and destruction of the framework in the course of the reaction. The major advantages of the presented methodology include easy work-up, cost effectiveness, nontoxic nature, broad substrate scope, 100% atom economy, ease of separation, and environment friendly reaction conditions. Finally, the catalyst could be reused many times without significant loss of activity. This journal is © The Royal Society of Chemistry.

Introduction

The development of green and straightforward multi-component reactions has attracted great deal of attention from the environment point of view. Multi-component reactions combine at least three reagents at the same time in a single pot to generate intended products in a short reaction time with enhanced atom economy. This interesting strategy can serve as a preferred tool, which has gained attention for traditional multi-step reactions and a new extension has emerged in synthetic organic chemistry as well as in biological scaffolds and the drug discovery field.[1-4] The principal reaction parameters such as temperature, solvents and catalyst amount strongly affect the selectivity, versatility and environmental acceptability of a multi-component reaction.

Photochemical condensation reactions have been first explored in the early 20th century and opened useful strategies in synthetic organic chemistry and extensive efforts are devoted to various effective contributing experimental parameters related to these types of transformations.[5-7] There is no doubt that light is a nonpolluting source of energy, which motivates many photochemical reactions and can effectively be considered as a green solution to reach a cleaner life. Therefore, chemists try to redesign the synthetic methods by focusing on visible resources. Visible light has the potential to act as an inexpensive, abundant, renewable, available source of energy, and a non-polluting reagent for chemical synthesis. Therefore, chemists have promoted photochemical reactions as an interesting filed in organic synthesis.[8-10] Among many advantages of photochemical reactions, traditional UV light sources have significant drawbacks including various technical complications, energy intensive nature, limited lifetime and considerable requirements due to dissipation of heat generated from the light source. In addition, the energy of a UV photon is generally in the range of carbon–carbon σ bonds, which induces problematic complications and may result in various unwanted photo induced decomposition reactions and the generation of obscure optical polymeric materials on the reactor wall.[11,12] However, most of these drawbacks can be solved by new modifications in reactor design and applying efficient LED lights.[13]

On the other hand, one fundamental impediment that limits the development of photochemical processes is that most organic molecules cannot absorb visible light. This issue limited the application of photochemical reactions and motivated the development of new effective visible light photocatalysts in chemical transformations.[14] Commonly the applied visible-light driven photocatalysts have been classified into two main families of organic and inorganic photosensitive materials. Organic visible light driven photocatalysts (sensitizers) are commonly organic compounds, which involve aromatic rings or conjugated unsaturated bonds that hold the irradiation energy with the help of quantum vibrations.[15] To achieve effective photocatalysts applicable in the visible spectrum of electromagnetic radiation, they should be colored and should consist of common metal-free organic dyes, whereas the most representative class of inorganic visible-light photocatalysts basically involve metal oxide semiconductors, coordination complexes and some colored metal–organic frameworks.[16]

Chromene derivatives are essential oxygenated heterocyclic compounds that have emerged as important ingredients of many biological active materials in drug chemistry and pharmacology.[17-19] Chromenes exist in various flavonoids, tocopherols and alkaloids, which exhibit diverse biological,[20] anti-cancer,[21] anti-HIV,[22] antialzheimer,[23] anti-tumor,[24] anti-bacterial,[25] anti-viral,[26] anti-leishmanial,[27] anticoagulant,[28] antitubercular,[29] anti-inflammatory,[30] and anti-tubulin activities.[31] In addition, chromenes can activate the potassium channels and may prohibit some reductases and some phosphodiesterases and these compounds have been utilized as cosmetics, pigments, biodegradable agrochemicals, colored optical lasers, brighteners, and fluorescence biomarkers.[32-34] There are many reports to synthesize varieties of chromeno[4,3-b]chromenes by the reaction of different arylaldehydes with 1,3-dicarbonyls and 4-hydroxycoumarin in the presence of various catalysts such as Ni(ii)–bis(oxazoline),[35] Fe3O4@SiO2–sultone,[36] WO3/ZnO@NH2-EY,[37] and Zn(l-proline)2.[38] Although most of these protocols are effective, some of them have some disadvantages such as side reactions, lengthy reaction time, tedious workup, high reaction temperature, moderate yields and non-reusable mediators. Therefore, development of novel synthetic green procedures is of great interest in synthetic organic chemistry because of environmental and economic concerns.

As photoredox catalysis obeys the general property of an excited state that is both more easily reducible and oxidizable than its corresponding ground states, herein and in continuation of our previous reports on the green multi-component synthesis of heterocycles,[39-42] we report our findings on using histaminium tetrachlorozincate as an effective and recoverable catalyst in the green, one-pot and multi-component synthesis of various chromene derivatives via the multi-component condensation of aromatic aldehydes with a suitable 1,3-diketone and 4-hydroxycoumarin under solventless condition at ambient temperature (Scheme 1). Herein, the used photocatalyst can serve either as an electron-donor or acceptor in the catalytic route. The photoreactivity property originates from the nature of the oxidized metal center and the reduced ligand.

Scheme 1

The general route describing the desired photocatalytic condensation reaction by the mediation of histaminium tetrachlorozincate as a photocatalyst.

Experimental section

Materials and methods

Solvents and all materials were purchased from commercial resources and utilized as received without any further purification. Histamine dihydrochloride (Sigma-Aldrich, >99%), aromatic aldehydes (Merck, Fluka and Sigma-Aldrich, 98–99%), dimedone (Sigma-Aldrich, >97%), 4-hydroxycoumarin (Fluka, purum), and acetonitrile (Sigma-Aldrich, 99.8%) were used as received. The performed LEDs were commercial and no cutoff filter was used. Fourier transform infrared (FT-IR) spectra were recorded on a Shimadzu 8700 Fourier transform spectrophotometer in the range 400 to 4000 cm−1 with KBr pellets. UV-visible spectra were recorded on a Photonix UV-visible array spectrophotometer. X-ray diffraction (XRD) patterns were acquired on a PHILIPS PW 1730 diffractometer with Cu Kα at 30 mA, 40 keV and a scanning rate of 3° min−1 in the 2θ domain from 5 to 80°. Energy dispersive X-ray spectroscopy (EDS) was performed with an Electron Probe Microanalyser JEOL JXA-8230 equipped with an energy dispersive spectrometer Bruker QUANTAX 200. A Mira 3-MU field emission scanning electron microscope (FESEM) was used to investigate the morphology of the synthesized nanomaterials. Particle size and further morphology studies were performed on a TEM (Philips CM-200 and Titan Krios). NMR experiments were carried out on a Bruker Avance DMX600 instrument operating at 400 MHz for proton.

Synthesis of histaminium tetrachlorozincate

Pure histaminium zinctetrachloride was prepared under solvothermal conditions by mixing of histamine dihydrochloride (0.21 g, 1.1 mmol) with ZnCl2 (0.06 g, 0.05 mmol) in warm methanol (65 °C, 13 mL). After mixing, the mixture was kept at room temperature for 24 h without disturbance. Finally, the resulting white precipitate was isolated, washed with deionized water and dried in air at 70 °C.

General route for the synthesis of chromeno[4,3-b]chromenes

To a 25 mL flask container, histaminium tetrachlorozincate (2 mg), benzaldehyde (100 mg, 1 mmol), dimedone (140 mg, 1 mmol) and 4-hydroxycoumarin (162 mg, 1 mmol) were added. In the case of reactions with the solvent, acetonitrile (3 mL) was used. Then, the mixture was irradiated with a visible green light-emitting diode (LED) at room temperature in an open air condition. Production of the desired chromene was monitored by TLC and after completion of the reaction, the reaction mixture was quenched with H2O (3 mL) and the remained precipitate was dissolved in EtOAc. Then, the ethyl acetate layer was removed and the aqueous phase was extracted with ethyl acetate (3 × 3 mL). Finally, the combined organic layer was dried on Na2SO4 and concentrated in a vacuum. The crude product could be further purified through column chromatography (100–200 mesh silica gel; EtOAc/hexane) to obtain the pure products.

Results and discussion

Physicochemical properties and characterization of histaminium tetrachlorozincate

Histamine (2-aminoethylimidazole) is a familiar, biocompatible and pharmacologically important material which can be suitable as a good ligand due to its unique characteristics under in vivo conditions and readily binds to several metal ions such as nickel(ii), cobalt(ii), zinc(ii) and copper(ii) to form complexes with moderate stability. Histamine free base involves an imidazole ring with an aminoethyl side-chain, which accepts a proton to give a histaminium dication. The chemical structure and morphology of the histaminium tetrachlorozincate photocatalyst were explored by means of SEM, EDX, FT-IR, NMR and XRD. FT-IR is used as the most informative technique to determine the surface interactions in the nanomaterial. Moreover, powder X-ray diffraction (XRD) can confirm the formation of the histaminium tetrachlorozincate framework. The morphology and particle size of histaminium tetrachlorozincate were further confirmed by TEM, SEM and EDX analyses. The latter clearly indicated that the material was pure and no impurity peaks were observed.

XRD analysis

The wide-angle XRD patterns of histamine (a), tetrachlorozincate (b) and histaminium tetrachlorozincate (c) are shown in Fig. 1. Free histamine exhibited several peaks at the 2θ of 12.4, 16.9, 19.7, 21.1, 23.4, 26.4, 28.3, 29.5, 34.0, 34.8, 35.5, 39.9, 48.5 and 51.2° (Fig. 1a). In addition, anionic tetrachlorozincate revealed many peaks at 17.4, 17.7, 22.3, 25.8, 27.1, 28.0, 29.4, 30.5, 32.5, 33.1, 36.1, 38.6, 39.3, 41.0, 43.3, 44.1, 44.8, 45.1, 46.2 and 47.1° (Fig. 1b). Eventually, the target composite nanomaterial showed the main peaks at the 2θ values of 16.5, 17.3, 18.8, 21.0, 23.8, 24.9, 25.0, 26.8, 28.1, 29.6, 30.2, 31.6, 34.1, 35.6, 36.8, 38.8, 41.6, 44.3 and 46.0° (Fig. 1c). Repeating XRD of this material under lower magnification showed the main peaks of 16.3, 24.8, 30.0 and 41.7° (inset of Fig. 1c). Comparison of these XRD patterns showed that the XRD of the new nanocomposite is mainly similar to that of tetrachlorozincate and histaminium ions had no significant effect on the crystal structure of anionic ZnCl42−. In addition, the average crystallite size of histaminium tetrachlorozincate is estimated by the use of Debye–Scherrer's equation (eqn (1)).where β is the excess width-line at the half-maximum of the diffraction peak in radians, θ is the Bragg angle in degrees, and λ is the wavelength. By calculation, an average crystallite size of about 24 nm was attained for this nanophotocatalyst.

Fig. 1

XRD patterns of histamine (a), tetrachlorozincate anion (b) and histaminium tetrachlorozincate (c).

FT-IR spectroscopy

FT-IR spectroscopy was used to define the structure of the synthesized catalyst. As shown in Fig. 2a, the peak at 3101 cm−1 is assigned to the C–H stretching of the imidazole ring in the histamine fragment. Secondary amine N–H stretching mode was observed at 3012 cm−1. The C–H stretching of the alkyl group was detected by the peaks at 2895 and 2848 cm−1. The bands at 1622 and 1517 cm−1 are due to the N–H bending and C–N stretching vibrations of the imidazole ring, respectively.[43] The FT-IR spectrum of histaminium tetrachlorozincate (Fig. 2b) is not significantly different from that of histamine and only the peak at 717 cm−1 confirmed the incorporation of zinc into the material, which is related to Zn–Cl stretching.

Fig. 2

FT-IR spectra of (a) histamine and (b) histaminium tetrachlorozincate.

NMR spectroscopy

There are three sites in histamine dihydrochloride, which can act as proton donating/accepting centers (Fig. 3a). The 1H NMR spectrum of histamine in CDC13 shows peaks at 3.21 (2H, t, CH2), 3.39 (2H, t, CH2), 7.43 (1H, s, ring CH), and 8.70 (1H, d, ring CH).[44] The 13C NMR of this compound also shows 5 peaks at 30.40 (C5), 41.73 (C4), 118.00 (C3), 134.64 (C2) and 134.96 (C1). The 1H NMR spectrum of histaminium tetrachlorozincate in D2O also revealed comparable peaks at 3.11 (2H, t, CH2), 3.30 (2H, t, CH2), 7.35 (1H, s, ring CH), and 8.61 (1H, d, ring CH) (Fig. 3b). The small up-field shift would be due to metal coordination. The 13C NMR of this compound also exhibited 5 peaks at 22.24 (C5), 38.13 (C4), 117.13 (C3), 128.35 (C2) and 133.93 (C1) (Fig. 3c). The little line-broadening would be due to a slow internal fluctuation with a timescale close to the NMR frequency.[45]

Fig. 3

Schematic representation of histamine (a) and 1H NMR (b) and 13C NMR (c) spectra of histaminium tetrachlorozincate.

SEM/EDS analysis

Scanning electron micrography and energy dispersive X-ray spectroscopy were used as beneficial methods to determine the morphology and chemistry of the individual particles and bulk materials (Fig. 4 and 5). EDS analysis clarified the included elements and brought a quantitative assessment of each element. This study confirmed the atomic concentration% of carbon (44.7), nitrogen (16.6), chlorine (29.3) and zinc (7.9) as the main elements of histaminium tetrachlorozincate and the molecular formula of C5H11Cl4N3Zn was recommended. In addition, the SEM image of this photocatalyst showed that the particles have an angular tile-shape with a wide range of sizes (Fig. 5a). The TEM image of histaminium tetrachlorozincate revealed a mean particle size of about 15–30 nm in most cases, which is in good agreement with XRD results (Fig. 5b).

Fig. 4

EDS pattern of histaminium tetrachlorozincate.

Fig. 5

SEM (a) and TEM (b) images of histaminium tetrachlorozincate.

UV-visible spectroscopy

The UV-Vis absorption spectrum of the photocatalyst was analyzed in order to investigate the viable mechanism involved in the effective visible light absorption. The UV-Vis absorption spectrum of histaminium tetrachlorozincate in the region of 200–300 nm (Fig. 6a) provided the band-gap edge, which may be ascribed to the photo-excitation occurring from the valence band to the conduction band. The optical band-gap of this sample was estimated using the Tauc plot based on the extrapolation of the linear slope to photon energy. The calculated band-gap energy of histaminium tetrachlorozincate was found to be 2.8 eV. The extrapolation plot of hv vs. (αhv)2 was applied to get the optical energy band-gap (Eg) as shown in Fig. 6b. In this relation, the analysis is performed based on the equation αhv = A(hv − Eg)n, where α, hv, Eg, and A refer to the absorption coefficient, light frequency, band-gap, and a constant, respectively.[46]

Fig. 6

(a) UV-Vis absorption spectrum and (b) the corresponding Tauc plot of histaminium tetrachlorozincate.

Catalytic tests

Impact of the light source on the catalytic condensation reaction

In order to derive the best conditions, a model reaction was conducted using benzaldehyde (1 mmol), dimedone (1 mmol), and 4-hydroxycoumarin (1 mmol) with the photocatalyst (0.001 g) under solvent conditions (acetonitrile, 3 mL) against irradiation with a green LED (λmax = 535 nm) (Table 1). The reaction mixture was set at room temperature in an open air test tube equipped with a magnet. The desired product chromeno[4,3-b]chromene was formed in good yield after 3 h. This experiment demonstrated that if we perform the reaction under the dark conditions, only a trace amount of the product would be obtained under the same conditions. In addition, a green LED was effective and resulted in 57% yield. Moreover, this condensation reaction was really a photocatalytic one because of the trace yield obtained under the dark conditions. Table 1 also shows that a green LED (λmax = 535 nm) achieved the best yield in comparison with other colors illuminating at the same power and under similar reaction conditions.

Optimization of the light source in the condensation reactiona

Entry	Light source	Light specification	Time (h)	Yieldb (%)
1	Dark	—	3	Trace
2	White LED	2.5 W	3	24
3	Green	2.5 W, λmax = 535 nm	3	57
4	Blue	2.5 W, λmax = 431 nm	3	46
5	Red	2.5 W, λmax = 695 nm	3	43
6	Violet	2.5 W, λmax = 455 nm	3	42

Reaction conditions: benzaldehyde (1 mmol), dimedone (1 mmol), and 4-hydroxycoumarin (1 mmol) with the photocatalyst (1 mg) under an open atmosphere at RT in 3 mL acetonitrile.

Yields refer to the isolated product in all cases.

Studying the impact of catalyst amount on the condensation reaction

The condensation reactions were carried out with different amounts of the photocatalyst in order to optimize the exact quantity of the needed photocatalyst under solvent conditions (Fig. 7). It was observed that 0.002 g of the photocatalyst is appropriate to achieve the best yield of 83%. However, a further increase in the catalyst amount had no clear effect on the yield% and reaction time.

Fig. 7

Effect of catalyst amount on the condensation reaction. The reaction conditions are described in Table 1. The reaction time was 3 h under solvent conditions (acetonitrile, 3 mL).

Role of reaction temperature

To improve the yield and accomplish the best conditions, the effect of temperature was also studied on the selected standard reaction of dimedone, benzaldehyde and 4-hydroxycoumarin (Fig. 8). As shown, yield% was a little decreased when the temperature increased from 25 to 55 °C. Also, a further increase of temperature did not alter the yield. Therefore, the temperature of 25 °C was kept as the best in all runs.

Fig. 8

Impact of temperature on the condensation reaction. The reaction conditions are described in Table 1. The reaction time was 3 h and 0.002 g of photocatalyst was used under solvent conditions (acetonitrile, 3 mL).

Role of reaction time under solvent-free conditions

The impact of time was also researched to explore the minimum time needed to reach the best yield under solvent-free conditions. It is evident that the photocatalyst had shown good activity because of 65% yield attained after 30 min. As shown in Fig. 9, 93% yield was reached after 40 min under the above optimum conditions in the absence of a solvent.

Fig. 9

Effect of time on the reaction progress. Benzaldehyde (1 mmol), dimedone (1 mmol), and 4-hydroxycoumarin (1 mmol) were reacted in the presence of the photocatalyst (2 mg) under an open atmosphere at room temperature with a green LED in the absence of a solvent.

Superiority of the presented protocol over some reported methodologies

As we know, some protocols have been used for the preparation of chromeno[4,3-b]chromenes under different conditions. Herein, the reaction yield of the performed condensation reaction contrasted with those reported (Table 2). Compared to all mentioned catalysts, the presented methodology is a special case that offers a successful route for one-pot single-step synthesis of the intended products under very mild conditions under an open atmosphere at room temperature by means of a green LED irradiation source. The comparison was made based on the catalyst concentration, reaction time and yield%. Clearly, the present report gives rise to a few advantages like using an environmentally benign photocatalyst under ambient reaction conditions to achieve different chromenes.

Comparison of the catalytic activity of histaminium tetrachlorozincate with some reported catalysts in the synthesis of chromeno[4,3-b]chromenea

Catalyst	Time (h)	Temp (°C)	Solvent	Yield (%)	Ref.
Histaminium tetrachlorozincate (2 mg)	40 min	r.t.	—	93	This work
Eozin Y (2 mol%)	3.5	r.t.	CH3CN	77	47
ZrO2 (10 mol%)	25 min	80	H2O	91	48
Fe(DS)3 (10 mol%)	2	70	H2O	87	49
CuFe2O4@SO3H (0.05 g)	2.5	70	EtOH	90	50
Fe3O4@SiO2@(CH2)3OMoO3H (2 mg)	45 min	80	—	90	51

Benzaldehyde was used in all cases.

Active species scavenging experiments

To identify the principal active species involved in the photocatalytic route, a number of scavenging experiments were conducted. p-Benzoquinone (BQ) as an O2˙− scavenger,[52] dichromate as an e− scavenger,[53] EDTA as an h+ scavenger,[54] and isopropyl alcohol (IPA) as a scavenger for the hydroxyl free radicals[55] were used during the standard photocatalytic reactions. These series of experiments established that all the used scavengers show a significant scavenging power with the order of BQ > IPA > EDTA > potassium dichromate > no scavenger (Fig. 10). However, it seems that the superoxide anion (O2˙−) is one of the major involved components because of its crucial role in the photocatalytic process. As a result, the superoxide radical-anion and hydroxyl radical would be the main species involved in the photocatalytic process.

Fig. 10

Effect of some familiar scavengers on the reaction progress under the standard reaction conditions (benzaldehyde (1 mmol), dimedone (1 mmol), and 4-hydroxycoumarin (1 mmol) were reacted in the presence of the photocatalyst (2 mg) under an open atmosphere at room temperature with a green LED under solvent-free conditions after 40 min). In all cases 1 × 103− M solution of the scavenger is used.

Synthesis of different chromeno[4,3-b]chromenes by histaminium tetrachlorozincate

The versatility of the current methodology was identified through the synthesis of a series of chromeno[4,3-b]chromene derivatives using some aromatic aldehydes (Table 3). Aromatic aldehydes with different electron withdrawing/donating groups created the desired products in acceptable yields. However, in agreement with previous reports, aldehydes bearing electron withdrawing groups reacted a little better than those with electron donating groups.

Substrate scope for the condensation of dimedone, benzaldehyde, and 4-hydroxycoumarina

Entry	Benzaldehyde	Diketone	Product	Yield (%)	Mp
					Found	Reported[56–58]
1				94	211	208–210
2				93	222–224	220–222
3				73	134–135	133–135
4				72	190–191	187–189
5				76	219–220	218–220
6				78	231–232	230–232

Reaction conditions: aldehyde (1 mmol), diketone (1 mmol), and 4-hydroxycoumarin (1 mmol) with the photocatalyst (2 mg) under an open atmosphere at room temperature by irradiation with a green LED (2.5 W, λmax = 535 nm). The reaction time was set at 40 min under solvent free conditions. Yields refer to the isolated product in all cases.

Studying the stability and reusability of histaminium tetrachlorozincate

To study the stability and reusability of histaminium tetrachlorozincate, the catalyst was detached from the reaction mixture after completion of the first run via a simple filtration. Then, the filtered catalyst was washed with a copious amount of toluene and dried at room temperature before the next run. The catalyst was examined for five subsequent runs and good reusability was detected (Fig. 11). The yield efficiency decreased from ∼93% in the first run to ∼86% after the fifth run that indicates only a small deactivation. Moreover, comparison of the infrared spectra of fresh histaminium tetrachlorozincate with that of the regenerated one after the 5th run proved the existence of principal characteristic bands around 1200–1800 cm−1, which clearly confirmed that the structure of histaminium tetrachlorozincate remained intact (Fig. 12). Typical experiments were repeated to confirm the reproducibility of the condensation reaction and the acquired yields were repeatable within ±5% alteration.

Fig. 11

Yield% vs. reusability of histaminium tetrachlorozincate.

Fig. 12

FT-IR spectra of (a) fresh histaminium tetrachlorozincate and (b) the reused material after the 5th run.

Hot filtration test

A hot filtration experiment was also performed to prove that the catalytic activity of the photocatalyst originates from histaminium tetrachlorozincate in the reaction mixture and not from the leached or decomposed fragments. For this purpose, 2 mg of histaminium tetrachlorozincate was added to a mixture of dimedone, 4-hydroxycoumarin and benzaldehyde in acetonitrile and the reaction was started for 1.5 h. In this part, the product yield was 52%. Then, toluene was added, the photocatalyst was separated and the reaction was continued for another 1.5 h with the filtrate. Yield% was increased to only 57%; therefore, no significant increase in yield% proved the stability of the photocatalyst during the reaction progress. Clearly, this experiment confirmed that a 5% increase in yield% would be due to the leached or decomposed fragments from the mother active nanocomposite.

Suggesting a plausible reaction pathway

A feasible mechanism is disclosed for the generation of chromenes catalyzed by histaminium tetrachlorozincate, as shown in Fig. 13.[47] Formation of chromeno[4,3-b]chromene (i) occurs by condensation of the Knoevenagel product (d) attained from diketone and aromatic aldehyde. Thereafter, chromeno[4,3-b]chromene can be formed by the intra-molecular cyclization of the activated carbonyl group via elimination of a water molecule. 4-Hydroxycoumarin (c) is converted into a radical-cation (e) through a single electron transfer path. The radical-cation (e) undergoes a Michael type addition with β-dicarbonyl-enone (d) to furnish compound (f). Again at the same time, the intermediate (f) can be converted into (g) by the mediation of the photocatalyst. Finally (h) undergoes a simple dehydration reaction and leads to the targeted molecule (i).

Fig. 13

A probable reaction pathway for the condensation reaction.

Finally, to demonstrate the applicability of the presented protocol, an experiment was planned on a gram scale under the optimized conditions (Scheme 2). Benzaldehyde (a) was reacted with dimedone (b) and 4-hydroxycoumarin (c) to give the desired chromeno[4,3-b]chromene (d) in ∼85% under solvent free conditions in about 60 min.

Scheme 2

Demonstration of the practicality of the presented protocol.

Spectral data of some synthesized chromenes

10,10-Dimethyl-7-(4-nitrophenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione (Table 3, entry 1)

Mp 208–210 °C, FT-IR: 2932, 1718, 1650, 1605, 1528, 1459, 1342, 1177, 1098, 1031, 863, 761 cm−1. 1H-NMR (400 MHz, CDCl3): 1.10 (s, 3H); 1.11 (s, 3H); 2.17 (d, J = 16.3 Hz, 1H); 2.24 (d, J = 16.3 Hz, 1H); 2.66 (d, J = 18.2 Hz, 1H); 2.73 (d, J = 18.2 Hz, 1H); 4.94 (s, 1H); 6.91 (d, J = 8.8 Hz, 2H); 7.05 (d, J = 8.8 Hz, 2H); 7.32–7.42 (m, 2H); 7.59 (t, J = 8.3 Hz, 1H); 7.88 (dd, J = 8.2 Hz, J = 1.5 Hz 1H). 13C-NMR (100 MHz, CDCl3): 27.3, 29.4, 31.2, 32.7, 40.8, 50.6, 114.8, 115.0, 115.2, 115.3, 115.4, 117.0, 122.4, 124.4, 129.7, 129.9, 130.1, 130.3, 132.3, 162.0, 162.2, 163.0, 196.5.

10,10-Dimethyl-7-phenyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione (Table 3, entry 2)

Mp 220–222 °C, FT-IR: 2961, 1711, 1663, 1604, 1492, 1452, 1362, 1324, 1289, 1182, 1165, 1051, 1032, 892, 765 cm−1. 1H-NMR (400 MHz, CDCl3): 1.08 (s, 3H); 1.12 (s, 3H); 2.22 (d, J = 16.3 Hz, 2H); 2.63 (d, J = 16.3 Hz, 2H); 4.98 (s, 1H); 7.16 (t, J = 7.3 Hz, 1H); 7.25 (t, J = 7.5 Hz, 2H); 7.29 (d, J = 7.7 Hz, 2H); 7.35–7.46 (m, 2H); 7.63 (t, J = 8.0 Hz, 1H); 7.85 (dd, J = 8.0 Hz, J = 1.9 Hz, 1H). 13C-NMR (100 MHz, CDCl3): 27.2, 28.8, 32.0, 33.3, 40.3, 50.8, 105.0, 114.1, 115.3, 115.8, 120.1, 123.1, 125.3, 127.5, 128.5, 131.1, 140.3, 153.2, 153.7, 161.8, 196.2.

7-(4-Bromophenyl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione (Table 3, entry 3)

Mp 133–135 °C, FT-IR: 3077, 2961, 2873, 1707, 1687, 1614, 1572, 1487, 1266 cm−1. 1H-NMR (400 MHz, CDCl3): 1.21 (2H, CH3), 1.35 (t, 2H, CH2), 2.2 (t, 2H, CH2), 2.3 (t, 1H, CH), 7.15–7.21 (m, 4H, aromatic), 7.2–7.8 (m, 4H, aromatic). 13C-NMR (100 MHz, CDCl3): 13.1, 19.5, 23.5, 58.4, 103.5, 104.9, 114.1, 118.7, 122.4, 123.9, 128.1, 129.1, 130.4, 130.4, 130.6, 131.0, 132.3, 138.4, 144.1, 152.7, 162.8, 165.8, 204.9.

10,10-Dimethyl-7-(4-methoxyphenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione (Table 3, entry 4)

Mp 187–189 °C, FT-IR: 2957, 1726, 1661, 1607, 1508, 1455, 1359, 1301, 1252, 1183, 1168, 1140, 1034, 893, 765 cm−1. 1H-NMR (400 MHz, CDCl3): 1.14 (s, 3H), 1.16 (s, 3H), 2.22 (m, 2H), 2.35 (m, 2H), 4.87 (s, 1H), 7.25 (d, J = 7.6 Hz, 2H), 7.44 (d, J = 7.6 Hz, 2H), 7.56 (m, 2H), 7.78 (t, J = 8.0 Hz, 1H), 7.97 (d, J = 8.0 Hz, 1H). 13C-NMR (100 MHz, CDCl3): 27.0, 27.1, 28.4, 30.2, 37.0, 54.6, 106.3, 114.1, 114.1, 115.3, 123.0, 123.9, 128.3, 135.8, 136.2, 138.3, 143.9, 150.7, 153.1, 156.6, 158.1, 161.1, 195.9.

9,10-Dihydro-7-(3-nitrophenyl)-7H,11H-benzopyrano[3,2-c]chromene-6,8-dione (Table 3, entry 5)

Mp 218–220 °C FT-IR: 3100, 2935, 1734, 1525, 1364 cm−1. 1H-NMR (400 MHz, CDCl3): 2.07–2.22 (m, 2H), 2.40–2.55 (m, 2H), 2.77–2.86 (m, 1H), 2.92–2.98 (m, 1H), 5.08 (s, 1H), 7.37 (d, 1H), 7.42 (t, 1H), 7.46 (t, 1H), 7.64 (t, 1H), 7.96 (m, 2H), 8.05–8.07 (m, 2H).

10,10-Dimethyl-7-(3-nitrophenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione (Table 3, entry 6)

Mp 230–232 °C, FT-IR: 2973, 1718, 1657, 1608, 1526, 1352, 1182, 1142, 1094, 1034, 1032, 818, 765 cm−1. 1H-NMR (400 MHz, CDCl3): 1.11 (s, 3H), 1.14 (s, 3H), 2.24 (d, J = 15.6 Hz, 2H), 2.42 (d, J = 16.3 Hz, 2H), 4.97 (s, 1H), 7.22 (t, J = 7.6 Hz, 1H), 7.29 (d, J = 7.5 Hz, 1H), 7.42 (d, J = 7.7 Hz, 2H), 7.62–7.68 (m, 2H), 7.87 (t, J = 7.9 Hz, 1H), 8.06 (d, J = 7.7 Hz, 1H). 13C-NMR (100 MHz, CDCl3): 28.3, 29.3, 30.5, 34.7, 39.4, 51.3, 107.0, 113.3, 114.0, 115.7, 122.6, 124.2, 127.0, 128.2, 128.8, 130.9, 132.7, 136.4, 138.3, 149.5, 155.1, 163.2, 196.2.

Conclusions

In conclusion, histaminium tetrachlorozincate is disclosed as an effective and recoverable photocatalyst in the synthesis of various chromeno[4,3-b]chromenes to achieve high yields under solvent-less conditions at ambient temperature. This new photocatalyst is characterized by FT-IR, XRD, EDX, NMR, SEM and TEM. It is found that incorporation of histaminium ions into the framework of ZnCl42− significantly affected the photocatalytic activity of tetrachlorozincate and led to a recyclable nanomaterial. The major advantages of the presented methodology include easy and cheap preparation of the photocatalyst, simple work-up, nontoxic nature, broad substrate scope and complete atom economy under environmental friendly conditions in the presence of a simple green LED light. We believe that this protocol will play an important role in medicinal synthetic organic chemistry using a potent and economic alternative to the preparation of target materials. This protocol can be scaled up easily under mild conditions without needing to add further additives; thus, this photocatalyst can occupy a vital role among various introduced photocatalysts in organic synthesis.

Conflicts of interest

There are no conflicts to declare.