Lyubomir Haralambiev1,2, Andreas Nitsch3, Cornelius S Fischer4, Anja Lange5, Ingrid Klöting3, Matthias B Stope6, Axel Ekkernkamp3,2, Jörn Lange3. 1. Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany; Lyubomir.haralambiev@uni-greifswald.de. 2. Department of Trauma and Orthopaedic Surgery, BG Klinikum Unfallkrankenhaus Berlin, Berlin, Germany. 3. Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany. 4. Department of Traumatology and Reconstructive Surgery, BG Trauma Center Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany. 5. Department of Pediatrics and Neonatology & Paediatric Intensive Care, University Medicine Greifswald, Greifswald, Germany. 6. Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany.
Abstract
BACKGROUND/AIM: The typical insulin deficiency in type 1 diabetes mellitus has general effects on metabolism and also affects bone quality. MATERIALS AND METHODS: Two diabetic rat lines (BB/OK; BB.6KWR) and two non-diabetic rat strains (KWR and BB.14+18KWR), as control group, were included in the study. Bone mineral density, bone mineral content and body structure measurements were performed. The measurements took place before the onset of diabetes mellitus Results: A comparison of the groups showed increased bone density values of the diabetic rats in relation to the control groups. A new finding of increased bone density in the diabetic rats occurs. CONCLUSION: Diabetic rats showed no osteoporotic bone metabolism before the onset of clinically relevant type 1 diabetes mellitus, but rather increased bone metabolic activity.
BACKGROUND/AIM: The typical insulin deficiency in type 1 diabetes mellitus has general effects on metabolism and also affects bone quality. MATERIALS AND METHODS: Two diabetic rat lines (BB/OK; BB.6KWR) and two non-diabetic rat strains (KWR and BB.14+18KWR), as control group, were included in the study. Bone mineral density, bone mineral content and body structure measurements were performed. The measurements took place before the onset of diabetes mellitus Results: A comparison of the groups showed increased bone density values of the diabetic rats in relation to the control groups. A new finding of increased bone density in the diabetic rats occurs. CONCLUSION: Diabetic rats showed no osteoporotic bone metabolism before the onset of clinically relevant type 1 diabetes mellitus, but rather increased bone metabolic activity.
Authors: T Forst; A Pfützner; P Kann; B Schehler; R Lobmann; H Schäfer; J Andreas; A Bockisch; J Beyer Journal: Diabet Med Date: 1995-10 Impact factor: 4.359
Authors: C Tsentidis; D Gourgiotis; L Kossiva; A Doulgeraki; A Marmarinos; A Galli-Tsinopoulou; K Karavanaki Journal: Osteoporos Int Date: 2015-11-20 Impact factor: 4.507
Authors: Lucy D Mastrandrea; Jean Wactawski-Wende; Richard P Donahue; Kathleen M Hovey; Angela Clark; Teresa Quattrin Journal: Diabetes Care Date: 2008-06-30 Impact factor: 19.112