Use of Lithium in Hyperthyroidism Secondary to Graves' Disease: A Case Report.

BACKGROUND The therapeutic approach to Graves' disease (GD) comprises thionamides, radioiodine ablation, or surgery as first-line therapy, and cholestyramine and oral iodine as second-line therapies. The role of lithium (Li) in GD as a primary or adjunctive therapy remains contentious. We present a case of GD managed by Li therapy with oral iodine solution. CASE REPORT A 26-year-old man, admitted with acute blast crisis secondary to chronic myeloid leukemia (CML), reported palpitations, 40-lb weight loss, heat intolerance, and fatigue. An examination revealed sinus tachycardia, elevated body temperature, and thyromegaly. Laboratory evaluation confirmed hyperthyroidism (TSH <0.005 mcIU/l, FT4 5.57 ng/dl, TT3 629 ng/dl) secondary to GD (TRAb >40 IU/l, TSIg 178%). Thionamides and surgery were contraindicated due to pancytopenia from a blast crisis. Inability to maintain post-radiation precautions precluded use of RAI. Cholestyramine was attempted and discontinued due to nausea. We introduced oral Li carbonate with oral iodine, which the patient tolerated. Thyroid functions improved with therapy (TSH 0.007 mcIU/l, FT4 0.82 ng/dl, TT3 122 ng/dl) with stable Li level (0.5-0.8 mmol/l). CONCLUSIONS Li inhibits iodine uptake through interference with sodium-iodide symporter and tyrosine iodination, thyroglobulin structure changes, peripheral deiodinase blockage, and preventing TSH and TSIg stimulation. Our case shows that a low therapeutic level of Li, in combination with oral iodine, can suppress thyroid overactivity without adverse effects. We suggest that low-dose Li carbonate is a safe and effective adjunctive antithyroid medication to be considered if primary therapies for hyperthyroidism are unavailable.

Background

First-line therapeutic approaches to hyperthyroidism secondary to Graves’ disease (GD) comprise symptom control with beta-blocker and decreasing thyroid hormone synthesis through thionamides (antithyroid drugs, ATDs), RAI, or surgery [1]. Methimazole and propylthiouracil (PTU) are the most common ATDs used in the United States. Relatively mild adverse effects from ATDs include pruritus, rash, urticaria, arthralgias, arthritis, nausea, vomiting, or abnormal taste, occurring in up to 13% patients [2]. Serious adverse effects include agranulocytosis, hepatotoxicity, and vasculitis [1]. Agranulocytosis is more likely to occur with any dose of PTU than with low-dose methimazole and can be life-threatening [1], while it is dose-dependent with methimazole [3]. It usually occurs within the first 2–3 months of therapy; however, the overall incidence is relatively low, at 0.1–0.5% [1]. Occurrence of agranulocytosis with either PTU or methimazole is a contraindication to the use of alternate ATDs due to cross-reactivity [1]. Therefore, one has to consider alternate therapy options. Second-line adjunctive therapies include cholestyramine, oral iodine solutions, and glucocorticoids [1,4]. Rarely, lithium (Li) has been considered as an adjunct due to its thyroid hormone-lowering effect [5-7]. Its role, however, remains contentious.

Case Report

A 26-year-old man was admitted with acute blast crisis secondary to chronic myeloid leukemia (CML). He reported palpitations, 40-lb weight loss, heat intolerance, and fatigue, which he had attributed to CML. Examination revealed sinus tachycardia with heart rate of 120–140/min, hypertension with systolic reading of 140–160 mmHg, elevated body temperature of 37–39°C, and a prominent thyroid gland, without visual abnormalities. The patient did not have any signs of cognitive or gastrointestinal dysfunction. He did not have shortness of breath or pedal edema. Based on the Burch-Wartofsky scoring system for thyroid storm, the patient scored up to 40 points, suggestive of but not confirmatory for thyroid storm clinically. Laboratory evaluation on Day 1 of admission confirmed hyperthyroidism with TSH <0.005 mcIU/l (range 0.45–4.5 uIU/ml), free T4 (FT4) 5.57 ng/dl (range 0.82–1.77 ng/dl), total T3 (TT3) 629 ng/dl (60–180 ng/dl) () secondary to GD (TRAb >40 IU/l (range 0.0–1.75 IU/L), and TSIg 178% (range <140% baseline) (Table ). Propranolol 40 mg 4 times a day was initiated for symptom control. ATDs and thyroidectomy were ruled out due to concerns of high morbidity and mortality from pancytopenia from the blast crisis. The patient was a prisoner and the prison would be unable to provide the post-radiation precautions (eg, social distancing, separate utensils for meals, and separate bathroom) required. Therefore, we were unable to proceed with RAI. The patient was prescribed cholestyramine 4 gm up to 3 times a day, which he only took for 1 day, after which he refused the medication due to excessive nausea and vomiting. Utilization of SSKI alone was considered but not pursued due to concern for worsening hyperthyroidism and precipitation of thyroid storm. Finally, after 2 weeks of inpatient hospital stay, oral Li carbonate 300 mg 3 times a day, with SSKI 50 mg/drop 1 drop 3 times a day, was introduced. Li levels were monitored every 2–3 days. Two weeks into treatment, FT4 and TT3 dropped to 4.51 ng/dl and 359 ng/dl, respectively. The patient tolerated Li without adverse effects. He reported nausea with the SSKI solution, but was willing to continue taking it. At hospital discharge 1 month later, thyroid tests showed improvement (TSH 0.007 mcIU/l, FT4 0.82 ng/dl, TT3 122 ng/dl) () with stable Li level (within 0.5–0.8 mmol/l) (). The patient was sent back to prison and, due to miscommunication, Li carbonate and SSKI were discontinued by the team there. A month later (Day 60), at hospitalization for additional CML therapy, the patient’s thyroid tests showed hyperthyroidism (TSH <0.005 mcIU/l, FT4 3.67 ng/dl, TT3 235 ng/dl) and undetectable Li level (<0.2 mmol/l). Due to previous efficacy, Li carbonate and SSKI were restarted, with good biochemical response after 8 days (FT4 2.15 ng/dl, TT3 167 ng/dl) with low Li level (0.3 mmol/l). Medications were held during the patient’s chemotherapy for CML due to nausea and vomiting, following which, thyroid functions testing showed biochemical hyperthyroidism on Day 75 (TSH <0.005 mcIU/l, FT4 4.56 ng/dl, TT3 286 ng/dl) with undetectable Li levels (<0.2 mmol/l). When he felt better, Li and SSKI were restarted, with ongoing good response. The patient was advised to continue both medications and to follow up with endocrinology in the outpatient setting. So far, he remains on oral Li carbonate 300 mg 3 times a day and SSKI 50 mg/drop 1 drop 3 times a day, without adverse effects. Most recent laboratory test results continue to show an undetectable TSH, but FT4 and TT3 are within normal range (1.42 ng/dl and 98 ng/dl, respectively). The ultimate plan for this patient is a total thyroidectomy when his cell counts improve.

Discussion

Li carbonate has long been used for treatment of bipolar disorder and manic-depressive disorders [8]. Hypothyroidism and goiter were noted in patients treated with Li, leading to more investigation regarding the mechanisms.

Li affects cell function by inhibitory action on ATPase, cAMP, and inositol phospholipid metabolism. In vitro, it decreases the response of cultured cells to thyrotropin-releasing hormone (TRH) [9]. The thyroid gland is capable of Li uptake and concentration. It then inhibits iodine uptake through sodium-iodide symporter interference and interferes with tyrosine iodination [9]. Li promotes the conversion of thyroxine to triiodothyronine in the thyroid gland [8]. It decreases colloid droplet formation within the thyroid follicular cells [10]. Changes in thyroglobulin structure are seen, likely due to impaired proteolytic digestion [10]. These mechanisms prevent thyroid hormone release. Data have also shown that Li affects the hypothalamic-pituitary-thyroid axis through alteration in thyroid hormone receptor in the hypothalamus and brain deiodinase enzymes [9]. Li blocks deiodinases in the periphery and prevents TSH or stimulating antibodies from stimulating cells via the hormone receptors [11,12]. This shows that Li plays a multifactorial role in lowering thyroid hormone levels. These effects tend to be reversible and resolve after discontinuation of Li [13]. The reversible and diverse mechanism of action of Li was the primary reason for utilization of Li in our patient, who could not tolerate primary therapy.

Use of iodine for acute treatment of hyperthyroidism is well-known. Iodine acutely inhibits its own uptake, oxidation, and thyroid hormone secretion [14]. This is termed as the Wolff-Chaikoff effect. However, this effect is transient and, ultimately, there is escape, leading to hyperthyroidism. Therefore, adjuvant therapy is essential to prevent escape and worsening hyperthyroidism. The role of Li in enhancing the efficacy of RAI ablation for hyperthyroidism through inhibition of iodine release without preventing RAI uptake has been described [15]. Thus, Li increases the half-life of the RAI, thereby prolonging the dose delivery. A recent meta-analysis of 6 randomized controlled trials demonstrated better cure rates of hyperthyroidism when Li was used as an adjunct to RAI [16]. The authors also showed, in a subgroup analysis, that adding Li to RAI therapy in Graves’ disease, led to 15% higher cure rates as compared to RAI alone.

From a dose standpoint, studies evaluating role of Li in hyperthyroidism have utilized doses of 500–900 mg daily [16]. These doses are much lower than those used to treat bipolar or psychotic disorders. Our patient’s daily dose of 900 mg was on the higher end of the doses studied in the literature so far. Studies have also suggested that a short course of Li (around 7 days) after administration of RAI dose is most beneficial for RAI [16,17]. The immediate improvement in thyroid function testing in our patient with the combination of Li and SSKI confirms that Li has an additive effect with SSKI. The combination also allowed for utilization of less SSKI for more a prolonged period of time without precipitating hyperthyroidism through the escape phenomenon.

Li takes about 4 days to reach steady-state concentration [12]. Due to Li’s narrow therapeutic range (0.8–1.2 mmol/l), it is essential to monitor Li levels closely during therapy. Lithium toxicity occurs at levels above 1.5 mmol/l. Acute toxicity can present as gastrointestinal (nausea, vomiting, diarrhea), neurological (sluggishness, ataxia, confusion, tremors, fasciculations), or cardiac (QTc prolongation) symptoms. Chronic toxicity can precipitate polyuria or polydipsia to nephrogenic diabetes insipidus [13]. Our patient had nausea and vomiting, but these were attributed to ongoing chemotherapy for CML. Additionally, since the Li levels did not go above 0.8 mmol/l, it is unlikely that his symptoms were Li-related. Other adverse effects were not seen, even after several weeks of Li therapy.

Our case provides evidence of the utility of Li carbonate in hyperthyroidism as an adjunctive medication to oral iodine. We were able to show that a low therapeutic level of Li is enough to suppress thyroid overactivity without significant adverse effects. Our patient did not achieve Li levels above 0.8 mmol/l with improvement in thyroid function testing. The effects of Li on the thyroid proved to be reversible in our patient. Hence, medication compliance with periodic blood work for thyroid and Li levels is important. This case report does not provide enough support for use of Li carbonate as a primary or stand-alone therapy for hyperthyroidism secondary to GD. This will require a large-scale randomized control trial.

Conclusions

We suggest that Li carbonate is an effective oral adjunctive antithyroid medication that can be used to treat hyperthyroidism secondary to GD when first-line therapeutic options are not available. Whether Li carbonate is an effective antithyroid drug when used alone remains to be seen.

Tabel 1.

Antibody levels at Day 1 and Day 60 of Li carbonate therapy.

Antibodies	Day 1	Day 60
TSH receptor Ab (≤1.75 IU/l)	>40	>40
Thyroid stimulating immunoglobulin (≤122%)	178	114