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Literature DB >> 3547404

Gonadotropin-releasing peptide from human follicular fluid: isolation, characterization, and chemical synthesis.

C H Li, K Ramasharma, D Yamashiro, D Chung.

Abstract

A gonadotropin-releasing peptide has been isolated from human follicular fluid. Its amino acid composition and sequence are completely different from the hypothalamic lutropin-releasing hormone. It is designated human follicular gonadotropin-releasing peptide and abbreviated as hF-GRP. The primary structure of this peptide (H-Thr-Asp-Thr-Ser-His-His-Asp-Gln-Asp-His-Pro-Thr-Phe-Asn-OH) has been confirmed by chemical synthesis. In the mouse pituitary incubation assay, the ED50 value for follitropin or lutropin release is estimated to be 1.2-1.6 nM.

Entities: Chemical Species

Mesh：

Substances：

Year: 1987 PMID： 3547404 PMCID： PMC304339 DOI： 10.1073/pnas.84.4.959

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

18 in total

1. Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin.

Authors: N Ling; S Y Ying; N Ueno; S Shimasaki; F Esch; M Hotta; R Guillemin
Journal: Nature Date: 1986 Jun 19-25 Impact factor: 49.962

2. [A new method for synthesis of peptides: activation of the carboxyl group with dicyclohexylcarbodiimide using 1-hydroxybenzotriazoles as additives].

Authors: W König; R Geiger
Journal: Chem Ber Date: 1970

Review 1. Growth factors in the ovary.

Authors: G Giordano; A Barreca; F Minuto
Journal: J Endocrinol Invest Date: 1992-10 Impact factor: 4.256

1 in total

Gonadotropin-releasing peptide from human follicular fluid: isolation, characterization, and chemical synthesis.

1. Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin.

2. [A new method for synthesis of peptides: activation of the carboxyl group with dicyclohexylcarbodiimide using 1-hydroxybenzotriazoles as additives].

Review 3. Precursor polyproteins in endocrine and neuroendocrine systems.

4. Cloning and expression in Escherichia coli of full-length complementary DNA coding for human alpha 1-antitrypsin.

Review 5. Structure and variation of human alpha 1-antitrypsin.

6. Cloning and sequence of cDNA coding for alpha 1-antitrypsin.

Review 7. Processing mechanisms in the biosynthesis of proteins.

8. Gonadocrinins: peptides in ovarian follicular fluid stimulating the secretion of pituitary gonadotropins.

9. The primary structure and genetic organization of the bovine papillomavirus type 1 genome.

10. Effect of inhibin like factors on gonadotrophin release by the mouse pituitary in vitro.

Review 1. Growth factors in the ovary.