RATIONALE: Modafinil has been proposed as a potentially effective clinical treatment for neuropsychiatric disorders characterized by cognitive control deficits. However, the precise effects of modafinil, particularly on brain network functions, are not completely understood. OBJECTIVES: To address this gap, we examined the effects of modafinil on resting-state brain activity in 30 healthy adults using microstate analysis. Electroencephalographic (EEG) microstates are discrete voltage topographies generated from resting-state network activity. METHODS: Using a placebo-controlled, within-subjects design, we examined changes to microstate parameters following placebo (0 mg), low (100 mg), and high (200 mg) modafinil doses. We also examined the functional significance of these microstates via associations between microstate parameters and event-related potential indexes of conflict monitoring and automatic error processing (N2 and error-related negativity) and behavioral responses (accuracy and RT) from a subsequent flanker interference task. RESULTS: Five microstates emerged following each treatment condition, including four canonical microstates (A-D). Modafinil increased microstate C proportion and occurrence regardless of dose, relative to placebo. Modafinil also decreased microstate A proportion and microstate B proportion and occurrence relative to placebo. These modafinil-related changes in microstate parameters were not associated with similar changes in flanker ERPs or behavior. Finally, modafinil made transitions between microstates A and B less likely and transitions from A and B to C more likely. CONCLUSIONS: Previous fMRI work has correlated microstates A and B with auditory and visual networks and microstate C with a salience network. Thus, our results suggest modafinil may deactivate large-scale sensory networks in favor of a higher order functional network during resting-state in healthy adults.
RATIONALE: Modafinil has been proposed as a potentially effective clinical treatment for neuropsychiatric disorders characterized by cognitive control deficits. However, the precise effects of modafinil, particularly on brain network functions, are not completely understood. OBJECTIVES: To address this gap, we examined the effects of modafinil on resting-state brain activity in 30 healthy adults using microstate analysis. Electroencephalographic (EEG) microstates are discrete voltage topographies generated from resting-state network activity. METHODS: Using a placebo-controlled, within-subjects design, we examined changes to microstate parameters following placebo (0 mg), low (100 mg), and high (200 mg) modafinil doses. We also examined the functional significance of these microstates via associations between microstate parameters and event-related potential indexes of conflict monitoring and automatic error processing (N2 and error-related negativity) and behavioral responses (accuracy and RT) from a subsequent flanker interference task. RESULTS: Five microstates emerged following each treatment condition, including four canonical microstates (A-D). Modafinil increased microstate C proportion and occurrence regardless of dose, relative to placebo. Modafinil also decreased microstate A proportion and microstate B proportion and occurrence relative to placebo. These modafinil-related changes in microstate parameters were not associated with similar changes in flanker ERPs or behavior. Finally, modafinil made transitions between microstates A and B less likely and transitions from A and B to C more likely. CONCLUSIONS: Previous fMRI work has correlated microstates A and B with auditory and visual networks and microstate C with a salience network. Thus, our results suggest modafinil may deactivate large-scale sensory networks in favor of a higher order functional network during resting-state in healthy adults.
Authors: Michael D Fox; Maurizio Corbetta; Abraham Z Snyder; Justin L Vincent; Marcus E Raichle Journal: Proc Natl Acad Sci U S A Date: 2006-06-20 Impact factor: 11.205
Authors: Anna Custo; Dimitri Van De Ville; William M Wells; Miralena I Tomescu; Denis Brunet; Christoph M Michel Journal: Brain Connect Date: 2017-11-17
Authors: Charles A Czeisler; James K Walsh; Thomas Roth; Rod J Hughes; Kenneth P Wright; Lilliam Kingsbury; Sanjay Arora; Jonathan R L Schwartz; Gwendolyn E Niebler; David F Dinges Journal: N Engl J Med Date: 2005-08-04 Impact factor: 91.245
Authors: Shima Kouhnavardi; Alev Ecevitoglu; Vladimir Dragačević; Fabrizio Sanna; Edgar Arias-Sandoval; Predrag Kalaba; Michael Kirchhofer; Jana Lubec; Marco Niello; Marion Holy; Martin Zehl; Matthias Pillwein; Judith Wackerlig; Rita Murau; Andrea Mohrmann; Kathryn R Beard; Harald H Sitte; Ernst Urban; Claudia Sagheddu; Marco Pistis; Roberto Plasenzotti; John D Salamone; Thierry Langer; Gert Lubec; Francisco J Monje Journal: Biomolecules Date: 2022-06-24