| Literature DB >> 35468177 |
Tanaya Manna1, Anshul Rajput1, Nirmal Saha1, Amit Mondal1, Subhas Chandra Debnath2, Syed Masood Husain1.
Abstract
Herein, the asymmetric and chemoenzymatic synthesis of (R)-nodulone C, cis-nodulone D and related (R)-dihydronaphthalenone is reported. It involves multistep chemical synthesis of putative biosynthetic substrates followed by regio- and stereoselective reduction using a NADPH-dependent tetrahydroxynaphthalene reductase of Magnaporthe grisea to obtain chiral nodulones in a biomimetic fashion.Entities:
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Year: 2022 PMID： 35468177 DOI： 10.1039/d2ob00401a
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876