Literature DB >> 35464550

Acquired Hepatocerebral Degeneration After a Splenorenal Shunt in the Sub-Saharan Africa Context: A Case Report and Brief Review of Literature.

Abdu Mohammed1, Abate Bane2, Getahun Mengistu3, Fekadu Ayalew4, Amir Sultan Seid2.   

Abstract

Acquired hepatocerebral degeneration (AHD) is a neurologic syndrome caused by liver dysfunction and long-standing portosystemic shunting. The pathogenesis of the condition is predominantly considered to be related to the deposition of manganese in parts of the brain due to shunting. We report a case of a 25-year-old male who underwent splenectomy and splenorenal shunt for recurrent upper GI bleeding (UGIB) due to esophageal varices caused by non-cirrhotic portal hypertension (NCPH). He presented with bradykinesia, hypophonia, gait instability, and rigidity of the lower extremities 18 months after the procedure was done.
Copyright © 2022, Mohammed et al.

Entities:  

Keywords:  acquired hepatocerebral degeneration; ethiopia; liver cirrhosis; non cirrhotic portal hypertension; splenorenal shunt; sub saharan africa

Year:  2022        PMID: 35464550      PMCID: PMC9001859          DOI: 10.7759/cureus.23064

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


  16 in total

Review 1.  Acquired hepatocerebral degeneration.

Authors:  Joseph Ferrara; Joseph Jankovic
Journal:  J Neurol       Date:  2009-02-17       Impact factor: 4.849

2.  Increased blood manganese in cirrhotic patients: relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms.

Authors:  L Spahr; R F Butterworth; S Fontaine; L Bui; G Therrien; P C Milette; L H Lebrun; J Zayed; A Leblanc; G Pomier-Layrargues
Journal:  Hepatology       Date:  1996-11       Impact factor: 17.425

3.  Two surgical procedures for esophagogastric variceal bleeding in patients with portal hypertension.

Authors:  Lin Yang; Li-Juan Yuan; Rui Dong; Ji-Kai Yin; Qing Wang; Tao Li; Jiang-Bin Li; Xi-Lin Du; Jian-Guo Lu
Journal:  World J Gastroenterol       Date:  2013-12-28       Impact factor: 5.742

4.  Improvement in chronic hepatocerebral degeneration following liver transplantation.

Authors:  E E Powell; M P Pender; J B Chalk; P J Parkin; R Strong; S Lynch; P Kerlin; W G Cooksley; W Cheng; L W Powell
Journal:  Gastroenterology       Date:  1990-04       Impact factor: 22.682

5.  Rifaximin is an efficacious treatment for the Parkinsonian phenotype of hepatic encephalopathy.

Authors:  Beverley Kok; Matthew R Foxton; Christopher Clough; Debbie L Shawcross
Journal:  Hepatology       Date:  2013-08-22       Impact factor: 17.425

6.  Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction.

Authors:  C Rose; R F Butterworth; J Zayed; L Normandin; K Todd; A Michalak; L Spahr; P M Huet; G Pomier-Layrargues
Journal:  Gastroenterology       Date:  1999-09       Impact factor: 22.682

7.  Are acquired hepatocerebral degeneration and hepatic myelopathy reversible?

Authors:  Binnur Pinarbasi; Sabahattin Kaymakoglu; Zeliha Matur; Filiz Akyuz; Kadir Demir; Fatih Besisik; Sadakat Ozdil; Gungor Boztas; Yilmaz Cakaloglu; Zeynel Mungan; Atilla Okten
Journal:  J Clin Gastroenterol       Date:  2009-02       Impact factor: 3.062

8.  Acute stroke-like presentation of acquired hepatocerebral degeneration.

Authors:  B Smita; V Abdul Gafoor; K Saifudheen; James Jose
Journal:  Ann Indian Acad Neurol       Date:  2014-04       Impact factor: 1.383

Review 9.  Schistosomiasis with a Focus on Africa.

Authors:  Oyime Poise Aula; Donald P McManus; Malcolm K Jones; Catherine A Gordon
Journal:  Trop Med Infect Dis       Date:  2021-06-22

Review 10.  Recent Updates on Acquired Hepatocerebral Degeneration.

Authors:  Hae-Won Shin; Hee Kyung Park
Journal:  Tremor Other Hyperkinet Mov (N Y)       Date:  2017-09-05
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