Lorenzo Angelini1, Eugenio Gioulis2, Nicoletta Civitareale2, Antonio Granata3, Christian Zanza4, Yaroslava Longhitano5, Angelica Zago2, Piernicola Machin6, Fabio Canal6, Armando Serao7, Gianluca Piccoli2, Salvatore Valerio8. 1. Department of Surgery, Section of Urology, SS Antonio and Biagio and Cesare Arrigo Hospital, Via Venezia, 16, 15121, Alessandria, Italy. lorenzo_t_angelini@yahoo.it. 2. Department of Radiology, Conegliano Hospital, Conegliano, Italy. 3. Nephrology and Dialysis Unit, Emergency Hospital "Cannizzaro", Catania, Italy. 4. Department of Emergency Medicine, Anesthesia and Critical Care, Michele and Pietro Ferrero Hospital, Verduno, Italy. 5. Department of Anesthesia and Critical Care, SS Antonio and Biagio and Cesare Arrigo Hospital, Alessandria, Italy. 6. Department of Pathology, Conegliano Hospital, Conegliano, Italy. 7. Department of Surgery, Section of Urology, SS Antonio and Biagio and Cesare Arrigo Hospital, Via Venezia, 16, 15121, Alessandria, Italy. 8. Department of Surgery, Section of Urology, Conegliano Hospital, Conegliano, Italy.
Abstract
PURPOSE: To assess the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) and computed tomography (CT) within Bosniak IIF/III categories. METHODS: After cystic renal mass diagnosis by contrast-enhanced CT, all patients with Bosniak score ≥ II also underwent CEUS between March 2017 and March 2019. Their exams were retrospectively analyzed. One experienced uro-radiologist performed every CEUS and reviewed the exams according to the EFSUMB 2020 Position Statement, while blinded to clinical data. CT Bosniak scores were retrospectively given blindly by two uro-radiologists (CT 1 and CT 2). We compared CEUS, CT 1 and CT 2 scores to clinical findings and histological tests. Clinical performance characteristics and area under the receiver operating characteristic (ROC) curves (AUCs) were determined separately for CEUS and CT, and then compared. RESULTS: 101 cystic masses were analyzed. In Bosniak categories IIF and III, the AUCs were 0.854 for CT 1, 0.779 for CT 2, and 0.746 for CEUS. CONCLUSION: Despite some statistical limitations, this study confirms that among cystic renal masses, those classified as Bosniak IIF and III are the most difficult to assess. The diagnostic performances of CEUS and CT are similar within this group. However, in experienced hands, CEUS could be valuable in further evaluation of ambiguous cystic masses, and in more ductile, safer, and cost-effective surveillance of those classified as Bosniak IIF and III. When challenging cystic renal masses occur, CEUS is a useful tool for clinical management and for the follow-up of non-surgical lesions.
PURPOSE: To assess the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) and computed tomography (CT) within Bosniak IIF/III categories. METHODS: After cystic renal mass diagnosis by contrast-enhanced CT, all patients with Bosniak score ≥ II also underwent CEUS between March 2017 and March 2019. Their exams were retrospectively analyzed. One experienced uro-radiologist performed every CEUS and reviewed the exams according to the EFSUMB 2020 Position Statement, while blinded to clinical data. CT Bosniak scores were retrospectively given blindly by two uro-radiologists (CT 1 and CT 2). We compared CEUS, CT 1 and CT 2 scores to clinical findings and histological tests. Clinical performance characteristics and area under the receiver operating characteristic (ROC) curves (AUCs) were determined separately for CEUS and CT, and then compared. RESULTS: 101 cystic masses were analyzed. In Bosniak categories IIF and III, the AUCs were 0.854 for CT 1, 0.779 for CT 2, and 0.746 for CEUS. CONCLUSION: Despite some statistical limitations, this study confirms that among cystic renal masses, those classified as Bosniak IIF and III are the most difficult to assess. The diagnostic performances of CEUS and CT are similar within this group. However, in experienced hands, CEUS could be valuable in further evaluation of ambiguous cystic masses, and in more ductile, safer, and cost-effective surveillance of those classified as Bosniak IIF and III. When challenging cystic renal masses occur, CEUS is a useful tool for clinical management and for the follow-up of non-surgical lesions.
Authors: Nicholas M Donin; Sanjay Mohan; Hai Pham; Hersh Chandarana; Ankur Doshi; Fang-Ming Deng; Michael D Stifelman; Samir S Taneja; William C Huang Journal: Clin Genitourin Cancer Date: 2014-07-03 Impact factor: 2.872