| Literature DB >> 35453679 |
Elvira Alfaro-Arnedo1, Icíar P López1, Sergio Piñeiro-Hermida2, Álvaro C Ucero3,4, Francisco J González-Barcala5,6,7, Francisco J Salgado8, José G Pichel1,7.
Abstract
In the original article [...].Entities:
Year: 2022 PMID: 35453679 PMCID: PMC9030783 DOI: 10.3390/biomedicines10040733
Source DB: PubMed Journal: Biomedicines ISSN: 2227-9059
Figure 4Therapeutic inhibition of IGF1R attenuates AHR and normalizes pulmonary surfactant expression upon HDM-induced allergy. (A) Quantification of lung resistance (LR) and dynamic compliance (Cdyn) to methacholine (MCh) evaluated by plethysmography (n = 4–8 mice per group) and (B) changes in lung tissue mRNA expression surfactant (Sftp) markers Sftpa1, b c, and d, normalized to 18S expression in HDM-challenged mice treated with NVP vs. controls (n = 5 mice per group). (C) Representative immunostains for SFTPC (green) (white arrowheads), and quantification of the number of SFTPC+ cells per unit area (mm2) in lung sections from HDM-challenged mice treated with NVP vs. controls (n = 5–10 mice per group; scale bar: 50 µm). Data are expressed as mean ± SEM. * p < 0.05; ** p < 0.01; *** p < 0.001; # p < 0.05 (comparisons within the same group) (Mann–Whitney U test or Student’s t-test for comparing two groups and Kruskal–Wallis test or ANOVA multiple comparison test for grouped or multivariate analysis).