Literature DB >> 35450367

A Stepwise Targeting Curcumin Derivative, Ser@TPP@CUR, for Acute Kidney Injury.

Xia Yan1, Xue-Ying Tan2, Yi-Xuan Li3, Hong-Bo Wang4, Jian-Bo Jin4, Ying-Rui Mao5, Jing-Bo Hu3, Ling-Hui Wu6.   

Abstract

Based on the pathological mechanisms of acute kidney injury (AKI), a stepwise targeting curcumin derivative, Ser@TPP@CUR, was developed in this study. Ser@TPP@CUR can be specifically internalized by renal tubular epithelial cells via KIM-1 receptor-mediated endocytosis and then actively distributed in mitochondria under the effect of TPP, a mitochondrial targeting molecule. Both in vitro and in vivo results showed that Ser@TPP@CUR effectively ameliorated injured renal tubular epithelial cells and improved renal functions of AKI mice.
© 2022 American Chemical Society.

Entities:  

Year:  2022        PMID： 35450367      PMCID： PMC9014501          DOI： 10.1021/acsmedchemlett.1c00585

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.632


  15 in total

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Authors:  Dong-Wei Wang; Shu-Juan Li; Xue-Ying Tan; Jin-Hui Wang; Ying Hu; Zeng Tan; Jing Liang; Jing-Bo Hu; Yan-Guo Li; Yu-Fen Zhao
Journal:  Carbohydr Polym       Date:  2020-12-31       Impact factor: 9.381

Review 2.  The role of antioxidants in the chemistry of oxidative stress: A review.

Authors:  Aurelia Magdalena Pisoschi; Aneta Pop
Journal:  Eur J Med Chem       Date:  2015-04-22       Impact factor: 6.514

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Authors:  Shima Hasanzadeh; Morgayn I Read; Abigail R Bland; Muhammed Majeed; Tannaz Jamialahmadi; Amirhossein Sahebkar
Journal:  Pharmacol Res       Date:  2020-05-25       Impact factor: 7.658

4.  Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells.

Authors:  Takaharu Ichimura; Edwin J P V Asseldonk; Benjamin D Humphreys; Lakshman Gunaratnam; Jeremy S Duffield; Joseph V Bonventre
Journal:  J Clin Invest       Date:  2008-05       Impact factor: 14.808

5.  The preventive effect of lotus seedpod procyanidins on cognitive impairment and oxidative damage induced by extremely low frequency electromagnetic field exposure.

Authors:  Yuqing Duan; Zhigao Wang; Haihui Zhang; Yuanqing He; Rongzhu Lu; Rui Zhang; Guibo Sun; Xiaobo Sun
Journal:  Food Funct       Date:  2013-08       Impact factor: 5.396

Review 6.  Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy.

Authors:  Fuad N Ziyadeh; Gunter Wolf
Journal:  Curr Diabetes Rev       Date:  2008-02

7.  Amelioration of sepsis-induced acute kidney injury through inhibition of inflammatory cytokines and oxidative stress in dendritic cells and neutrophils respectively in mice: Role of spleen tyrosine kinase signaling.

Authors:  Naif O Al-Harbi; Ahmed Nadeem; Sheikh F Ahmad; Mohammed M Alanazi; Abdullah A Aldossari; Fawaz Alasmari
Journal:  Biochimie       Date:  2018-12-29       Impact factor: 4.079

8.  Kidney Injury Molecule-1 Is Upregulated in Renal Lipotoxicity and Mediates Palmitate-Induced Tubular Cell Injury and Inflammatory Response.

Authors:  Xueying Zhao; Xiaoming Chen; Yuanyuan Zhang; Jasmine George; Alyssa Cobbs; Guoshen Wang; Lingyun Li; Nerimiah Emmett
Journal:  Int J Mol Sci       Date:  2019-07-11       Impact factor: 5.923

9.  Impact of Dexmedetomidine Infusion on Postoperative Acute Kidney Injury in Elderly Patients Undergoing Major Joint Replacement: A Retrospective Cohort Study.

Authors:  He Zhu; Aolin Ren; Kang Zhou; Qiuchong Chen; Mengjun Zhang; Jindong Liu
Journal:  Drug Des Devel Ther       Date:  2020-11-02       Impact factor: 4.162

Review 10.  The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species.

Authors:  Brandán Pedre; Uladzimir Barayeu; Daria Ezeriņa; Tobias P Dick
Journal:  Pharmacol Ther       Date:  2021-06-23       Impact factor: 12.310
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