Literature DB >> 35450350

Phosphoramidate Prodrugs Continue to Deliver: The Journey of Remdesivir (GS-5734) from the Liver to Peripheral Blood Mononuclear Cells.

Victoria C Yan1.   

Abstract

Remdesivir (GS-5734) is a monophenol, 2-ethylbutylalanine phosphoramidate prodrug of GS-441524 that is FDA-approved for the treatment of patients hospitalized for COVID-19. Despite showing strong, broad-spectrum antiviral activity in preclinical models, the clinical efficacy of remdesivir is mixed. This work highlights the pharmacodynamic discordance of remdesivir between humans and non-human primates, thereby demonstrating that non-human primate disease models overestimate the therapeutic efficacy of phosphoramidate prodrugs.
© 2022 American Chemical Society.

Entities:  

Year:  2022        PMID： 35450350      PMCID： PMC9014429          DOI： 10.1021/acsmedchemlett.2c00105

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.632


  23 in total

1.  Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir.

Authors:  Ting Wang; Darius Babusis; Yeojin Park; Congrong Niu; Cynthia Kim; Xiaofeng Zhao; Bing Lu; Bin Ma; Robert C Muench; Diana Sperger; Adrian S Ray; Eisuke Murakami
Journal:  Drug Metab Pharmacokinet       Date:  2020-04-16       Impact factor: 3.614

2.  Cell number and cell characteristics of the normal human lung.

Authors:  J D Crapo; B E Barry; P Gehr; M Bachofen; E R Weibel
Journal:  Am Rev Respir Dis       Date:  1982-06

3.  Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV.

Authors:  Richard L Mackman; Hon C Hui; Michel Perron; Eisuke Murakami; Christopher Palmiotti; Gary Lee; Kirsten Stray; Lijun Zhang; Bindu Goyal; Kwon Chun; Daniel Byun; Dustin Siegel; Scott Simonovich; Venice Du Pont; Jared Pitts; Darius Babusis; Arya Vijjapurapu; Xianghan Lu; Cynthia Kim; Xiaofeng Zhao; Julie Chan; Bin Ma; Diane Lye; Adelle Vandersteen; Sarah Wortman; Kimberly T Barrett; Maria Toteva; Robert Jordan; Raju Subramanian; John P Bilello; Tomas Cihlar
Journal:  J Med Chem       Date:  2021-04-09       Impact factor: 7.446

4.  Antiviral treatment using the adenosine nucleoside analogue GS-441524 in cats with clinically diagnosed neurological feline infectious peritonitis.

Authors:  Peter J Dickinson; Michael Bannasch; Sara M Thomasy; Vishal D Murthy; Karen M Vernau; Molly Liepnieks; Elizabeth Montgomery; Kelly E Knickelbein; Brian Murphy; Niels C Pedersen
Journal:  J Vet Intern Med       Date:  2020-05-22       Impact factor: 3.333

5.  Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis.

Authors:  Niels C Pedersen; Michel Perron; Michael Bannasch; Elizabeth Montgomery; Eisuke Murakami; Molly Liepnieks; Hongwei Liu
Journal:  J Feline Med Surg       Date:  2019-02-13       Impact factor: 2.015

6.  Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial.

Authors:  Yeming Wang; Dingyu Zhang; Guanhua Du; Ronghui Du; Jianping Zhao; Yang Jin; Shouzhi Fu; Ling Gao; Zhenshun Cheng; Qiaofa Lu; Yi Hu; Guangwei Luo; Ke Wang; Yang Lu; Huadong Li; Shuzhen Wang; Shunan Ruan; Chengqing Yang; Chunlin Mei; Yi Wang; Dan Ding; Feng Wu; Xin Tang; Xianzhi Ye; Yingchun Ye; Bing Liu; Jie Yang; Wen Yin; Aili Wang; Guohui Fan; Fei Zhou; Zhibo Liu; Xiaoying Gu; Jiuyang Xu; Lianhan Shang; Yi Zhang; Lianjun Cao; Tingting Guo; Yan Wan; Hong Qin; Yushen Jiang; Thomas Jaki; Frederick G Hayden; Peter W Horby; Bin Cao; Chen Wang
Journal:  Lancet       Date:  2020-04-29       Impact factor: 79.321

7.  Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys.

Authors:  Emily Speranza; Brandi N Williamson; Friederike Feldmann; Gail L Sturdevant; Lizzette Pérez-Pérez; Kimberly Meade-White; Brian J Smith; Jamie Lovaglio; Craig Martens; Vincent J Munster; Atsushi Okumura; Carl Shaia; Heinz Feldmann; Sonja M Best; Emmie de Wit
Journal:  Sci Transl Med       Date:  2021-01-11       Impact factor: 17.956

8.  Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.

Authors:  Hongchao Pan; Richard Peto; Ana-Maria Henao-Restrepo; Marie-Pierre Preziosi; Vasee Sathiyamoorthy; Quarraisha Abdool Karim; Marissa M Alejandria; César Hernández García; Marie-Paule Kieny; Reza Malekzadeh; Srinivas Murthy; K Srinath Reddy; Mirta Roses Periago; Pierre Abi Hanna; Florence Ader; Abdullah M Al-Bader; Almonther Alhasawi; Emma Allum; Athari Alotaibi; Carlos A Alvarez-Moreno; Sheila Appadoo; Abdullah Asiri; Pål Aukrust; Andreas Barratt-Due; Samir Bellani; Mattia Branca; Heike B C Cappel-Porter; Nery Cerrato; Ting S Chow; Najada Como; Joe Eustace; Patricia J García; Sheela Godbole; Eduardo Gotuzzo; Laimonas Griskevicius; Rasha Hamra; Mariam Hassan; Mohamed Hassany; David Hutton; Irmansyah Irmansyah; Ligita Jancoriene; Jana Kirwan; Suresh Kumar; Peter Lennon; Gustavo Lopardo; Patrick Lydon; Nicola Magrini; Teresa Maguire; Suzana Manevska; Oriol Manuel; Sibylle McGinty; Marco T Medina; María L Mesa Rubio; Maria C Miranda-Montoya; Jeremy Nel; Estevao P Nunes; Markus Perola; Antonio Portolés; Menaldi R Rasmin; Aun Raza; Helen Rees; Paula P S Reges; Chris A Rogers; Kolawole Salami; Marina I Salvadori; Narvina Sinani; Jonathan A C Sterne; Milena Stevanovikj; Evelina Tacconelli; Kari A O Tikkinen; Sven Trelle; Hala Zaid; John-Arne Røttingen; Soumya Swaminathan
Journal:  N Engl J Med       Date:  2020-12-02       Impact factor: 91.245

9.  Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients.

Authors:  Robert L Gottlieb; Carlos E Vaca; Roger Paredes; Jorge Mera; Brandon J Webb; Gilberto Perez; Godson Oguchi; Pablo Ryan; Bibi U Nielsen; Michael Brown; Ausberto Hidalgo; Yessica Sachdeva; Shilpi Mittal; Olayemi Osiyemi; Jacek Skarbinski; Kavita Juneja; Robert H Hyland; Anu Osinusi; Shuguang Chen; Gregory Camus; Mazin Abdelghany; Santosh Davies; Nicole Behenna-Renton; Frank Duff; Francisco M Marty; Morgan J Katz; Adit A Ginde; Samuel M Brown; Joshua T Schiffer; Joshua A Hill
Journal:  N Engl J Med       Date:  2021-12-22       Impact factor: 91.245
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.