Literature DB >> 35450177

Clinical outcome of orbital apex syndrome in COVID associated mucormycosis patients in a tertiary care hospital.

Smiti Rani Srivastava1, Purban Ganguly1, Debasis Barman1, Sudip Das1, Manimoy Bandyopadhyay1, Asim Kumar Ghosh1, Subhra Sarkar1, Amitabha Sengupta1, Sarbari Swaika1, Pritam Chatterjee1, Amit Kumar Gupta1, Alok Ranjan Mondal1, Soumyajit Guha1, Sinjita Dutta1, Souvik Adhikari1, Aditi Kaushik1, Partha Sundar Biswas1, Asif Ayub1.   

Abstract

AIM: To share clinical pattern of presentation, the modalities of surgical intervention and the one month post-surgical outcome of rhino-orbito-mucormycosis (ROCM) cases.
METHODS: All COVID associated mucormycosis (CAM) patients underwent comprehensive multidisciplinary examination by ophthalmologist, otorhinolaryngologist and physician. Patients with clinical and radiological evidence of orbital apex involvement were included in the study. Appropriate medical and surgical intervention were done to each patient. Patients were followed up one-month post intervention.
RESULTS: Out of 89 CAM patients, 31 (34.8%) had orbital apex syndrome. Sixty-six (74.2%) of such patients had pre-existing diabetes mellitus, 18 (58%) patients had prior documented use of steroid use, and 55 (61.8%) had no light perception (LP) presenting vision. Blepharoptosis, proptosis, complete ophthalmoplegia were common clinical findings. Seventeen (19.1%) of such patients had variable amount of cavernous sinus involvement. Endoscopic debridement of paranasal sinuses and orbit with or without eyelid sparing limited orbital exenteration was done in most cases, 34 (38.2%) patients could retain vision in the affected eye.
CONCLUSION: Orbital apex involvement in CAM patients occur very fast. It not only leads to loss of vision but also sacrifice of the eyeball, orbital contents and eyelids. Early diagnosis and prompt intervention can preserve life, vision and spare mutilating surgeries. International Journal of Ophthalmology Press.

Entities:  

Keywords:  COVID associated mucormycosis; endoscopic paranasal sinus debridement; orbital apex syndrome; orbital exenteration; rhino-orbito-cerebral mucormycosis

Year:  2022        PMID: 35450177      PMCID: PMC8995734          DOI: 10.18240/ijo.2022.04.01

Source DB:  PubMed          Journal:  Int J Ophthalmol        ISSN: 2222-3959            Impact factor:   1.779


  18 in total

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6.  A retrospective analysis of eleven cases of invasive rhino-orbito-cerebral mucormycosis presented with orbital apex syndrome initially.

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9.  The development of the acute inflammatory response to experimental cutaneous mucormycosis in normal and diabetic rabbits.

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10.  Rise of the phoenix: Mucormycosis in COVID-19 times.

Authors:  Swati A Ravani; Garima A Agrawal; Parth A Leuva; Palak H Modi; Krisha D Amin
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