Christina M Eckhardt1, Andrea A Baccarelli2, Haotian Wu3. 1. Division of Pulmonary, Allergy and Critical, Care Medicine, Department of Medicine, Columbia University Irving Medical Center, 630 West 168th Street, Floor 8, Suite 101, New York, NY, 10032, USA. 2. Environmental Health Sciences Department, Columbia University Mailman School of Public Health, 630 West 168th Street, Room 16-416, New York, NY, 10032, USA. 3. Environmental Health Sciences Department, Columbia University Mailman School of Public Health, 630 West 168th Street, Room 16-416, New York, NY, 10032, USA. Hw2694@cumc.columbia.edu.
Abstract
PURPOSE OF REVIEW: Environmental pollutants contribute to the pathogenesis of numerous diseases including chronic cardiovascular, respiratory, and neurodegenerative diseases, among others. Emerging evidence suggests that extracellular vesicles (EVs) may mediate the association of environmental exposures with chronic diseases. The purpose of this review is to describe the impact of common environmental exposures on EVs and their role in linking environmental pollutants to the pathogenesis of chronic systemic diseases. RECENT FINDINGS: Common environmental pollutants including particulate matter, tobacco smoke, and chemical pollutants trigger the release of EVs from multiple systems in the body. Existing research has focused primarily on air pollutants, which alter EV production and release in the lungs and systemic circulation. Air pollutants also impact the selective loading of EV cargo including microRNA and proteins, which modify the cellular function in recipient cells. As a result, pollutant-induced EVs often contribute to a pro-inflammatory and pro-thrombotic milieu, which increases the risk of pollutant-related diseases including obstructive lung diseases, cardiovascular disease, neurodegenerative diseases, and lung cancer. Common environmental exposures are associated with multifaceted changes in EVs that lead to functional alterations in recipient cells and contribute to the pathogenesis of chronic systemic diseases. EVs may represent emerging targets for the prevention and treatment of diseases that stem from environmental exposures. However, novel research is required to expand our knowledge of the biological action of EV cargo, elucidate determinants of EV release, and fully understand the impact of environmental pollutants on human health.
PURPOSE OF REVIEW: Environmental pollutants contribute to the pathogenesis of numerous diseases including chronic cardiovascular, respiratory, and neurodegenerative diseases, among others. Emerging evidence suggests that extracellular vesicles (EVs) may mediate the association of environmental exposures with chronic diseases. The purpose of this review is to describe the impact of common environmental exposures on EVs and their role in linking environmental pollutants to the pathogenesis of chronic systemic diseases. RECENT FINDINGS: Common environmental pollutants including particulate matter, tobacco smoke, and chemical pollutants trigger the release of EVs from multiple systems in the body. Existing research has focused primarily on air pollutants, which alter EV production and release in the lungs and systemic circulation. Air pollutants also impact the selective loading of EV cargo including microRNA and proteins, which modify the cellular function in recipient cells. As a result, pollutant-induced EVs often contribute to a pro-inflammatory and pro-thrombotic milieu, which increases the risk of pollutant-related diseases including obstructive lung diseases, cardiovascular disease, neurodegenerative diseases, and lung cancer. Common environmental exposures are associated with multifaceted changes in EVs that lead to functional alterations in recipient cells and contribute to the pathogenesis of chronic systemic diseases. EVs may represent emerging targets for the prevention and treatment of diseases that stem from environmental exposures. However, novel research is required to expand our knowledge of the biological action of EV cargo, elucidate determinants of EV release, and fully understand the impact of environmental pollutants on human health.
Authors: Rodosthenis S Rodosthenous; Itai Kloog; Elena Colicino; Jia Zhong; Luis A Herrera; Pantel Vokonas; Joel Schwartz; Andrea A Baccarelli; Diddier Prada Journal: Environ Res Date: 2018-09-05 Impact factor: 6.498
Authors: Danièle M I Kerr; Katriona J M Brooksbank; Richard G Taylor; Karine Pinel; Francisco J Rios; Rhian M Touyz; Christian Delles Journal: J Hypertens Date: 2019-01 Impact factor: 4.844
Authors: Rodosthenis S Rodosthenous; Brent A Coull; Quan Lu; Pantel S Vokonas; Joel D Schwartz; Andrea A Baccarelli Journal: Part Fibre Toxicol Date: 2016-03-08 Impact factor: 9.400
Authors: Angela R McLean; Ella K Adlen; Elisabeth Cardis; Alex Elliott; Dudley T Goodhead; Mats Harms-Ringdahl; Jolyon H Hendry; Peter Hoskin; Penny A Jeggo; David J C Mackay; Colin R Muirhead; John Shepherd; Roy E Shore; Geraldine A Thomas; Richard Wakeford; H Charles J Godfray Journal: Proc Biol Sci Date: 2017-09-13 Impact factor: 5.349