Kathrin Becker1, Robert Kerberger1, Giulia Brunello2,3, Joel Rockhoff1, Nicole Rauch2, Frank Schwarz4. 1. Department for Orthodontics, Universitätsklinikum Düsseldorf, Düsseldorf, Germany. 2. Department of Oral Surgery, Universitätsklinikum Düsseldorf, Düsseldorf, Germany. 3. Department of Neuroscience, Dental School, University of Padova, Padova, Italy. 4. Department of Oral Surgery and Implantology, Goethe University, Carolinum, Frankfurt, Germany. f.schwarz@med.uni-frankfurt.de.
Abstract
OBJECTIVES: The objective of this study was to volumetrically assess changes in the periodontal microstructure under antiresorptive therapy. MATERIALS AND METHODS: Microtomographic scans from a total of 9 Dutch Belted rabbits having been randomly allocated to either the intravenous administration of amino-bisphosphonate (zoledronic acid) (Za) (n = 5) or a negative control group (nZa) (n = 4) were obtained at 10 months following a repeated drug administration. A quantification of the periodontal space thickness (P.Th) of both maxillary and mandibular most posterior premolars, as well as of the 2nd molars was performed. Bone micromorphometry was assessed by means of bone volume per total volume (BV/TV), the bone mineral density (BMD), trabecular thickness (Tb.Th), trabecular number (Tb.N), bone surface (BS), and the specific bone surface (BS/BV). RESULTS: Za was associated with significantly higher P.Th (P = 0.010), which was most pronounced in the upper jaw. Bone micromorphometry revealed no significant differences among the two groups, i.e., Za and nZa, for all the investigated parameters. CONCLUSIONS: Volumetric analysis revealed that antiresorptive therapy was associated with periodontal space widening, whereas major effects on the bone micro-morphology could not be observed. CLINICAL RELEVANCE: A deep understanding of specific periodontal and alveolar bone alterations in patients under antiresorptive therapy might help to prevent the onset of medication-related osteonecrosis of the jaw.
OBJECTIVES: The objective of this study was to volumetrically assess changes in the periodontal microstructure under antiresorptive therapy. MATERIALS AND METHODS: Microtomographic scans from a total of 9 Dutch Belted rabbits having been randomly allocated to either the intravenous administration of amino-bisphosphonate (zoledronic acid) (Za) (n = 5) or a negative control group (nZa) (n = 4) were obtained at 10 months following a repeated drug administration. A quantification of the periodontal space thickness (P.Th) of both maxillary and mandibular most posterior premolars, as well as of the 2nd molars was performed. Bone micromorphometry was assessed by means of bone volume per total volume (BV/TV), the bone mineral density (BMD), trabecular thickness (Tb.Th), trabecular number (Tb.N), bone surface (BS), and the specific bone surface (BS/BV). RESULTS: Za was associated with significantly higher P.Th (P = 0.010), which was most pronounced in the upper jaw. Bone micromorphometry revealed no significant differences among the two groups, i.e., Za and nZa, for all the investigated parameters. CONCLUSIONS: Volumetric analysis revealed that antiresorptive therapy was associated with periodontal space widening, whereas major effects on the bone micro-morphology could not be observed. CLINICAL RELEVANCE: A deep understanding of specific periodontal and alveolar bone alterations in patients under antiresorptive therapy might help to prevent the onset of medication-related osteonecrosis of the jaw.
Authors: Frank Schwarz; Gordon John; Jürgen Becker; Knut Achim Grötz; Robert Sader; Ilja Mihatovic Journal: Clin Implant Dent Relat Res Date: 2020-06-15 Impact factor: 3.932
Authors: Terresa Kim; Sol Kim; Minju Song; Cindy Lee; Hideo Yagita; Drake W Williams; Eric C Sung; Christine Hong; Ki-Hyuk Shin; Mo K Kang; No-Hee Park; Reuben H Kim Journal: Am J Pathol Date: 2018-07-27 Impact factor: 5.770