Christen L Vagts1,2, Israel Rubinstein1,2. 1. University of Illinois, Chicago. 2. Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois.
Abstract
Background: Nontuberculous Mycobacterium-related pulmonary disease (NTM-PD) is commonly caused by Mycobacterium avium complex (MAC) and is increasingly recognized in veterans. NTM-PD carries an increased risk of mortality, and lack of treatment is an predictor of increased mortality. Methods: We describe the clinical characteristics of veterans diagnosed with MAC-pulmonary disease (MAC-PD) followed in a health care setting with varying treatment practices. We reviewed the electronic health records of veterans without HIV who had sputum culture-positive MAC-PD followed at the Jesse Brown Veteran Affairs Medical Center in Chicago, Illinois. Results: We identified 19 veterans diagnosed with MAC-PD between 2008 and 2019. They were predominantly male (89.5%), Black (73.6%), and had a median age of 74 years. Sixteen veterans (84.2%) had underlying lung disease, and 16 (84.2%) were current or former smokers. Respiratory symptoms were reported in 17 veterans (89.5%). Guideline-directed combination antimycobacterial therapy was initiated in 10 veterans (52.6%); however, only 5 (50.0%) completed treatment. Comorbidities, symptoms, and findings on chest imaging at diagnosis were similar among treated and untreated veterans. Conclusions: Clinical, imaging, and treatment attributes of MAC-PD in veterans without HIV who reside in metropolitan Chicago are heterogeneous and are associated with a relatively high mortality rate. Further studies are warranted to characterize MAC-PD and its treatment in veterans without HIV who reside in underresourced urban communities in the US.
Background: Nontuberculous Mycobacterium-related pulmonary disease (NTM-PD) is commonly caused by Mycobacterium avium complex (MAC) and is increasingly recognized in veterans. NTM-PD carries an increased risk of mortality, and lack of treatment is an predictor of increased mortality. Methods: We describe the clinical characteristics of veterans diagnosed with MAC-pulmonary disease (MAC-PD) followed in a health care setting with varying treatment practices. We reviewed the electronic health records of veterans without HIV who had sputum culture-positive MAC-PD followed at the Jesse Brown Veteran Affairs Medical Center in Chicago, Illinois. Results: We identified 19 veterans diagnosed with MAC-PD between 2008 and 2019. They were predominantly male (89.5%), Black (73.6%), and had a median age of 74 years. Sixteen veterans (84.2%) had underlying lung disease, and 16 (84.2%) were current or former smokers. Respiratory symptoms were reported in 17 veterans (89.5%). Guideline-directed combination antimycobacterial therapy was initiated in 10 veterans (52.6%); however, only 5 (50.0%) completed treatment. Comorbidities, symptoms, and findings on chest imaging at diagnosis were similar among treated and untreated veterans. Conclusions: Clinical, imaging, and treatment attributes of MAC-PD in veterans without HIV who reside in metropolitan Chicago are heterogeneous and are associated with a relatively high mortality rate. Further studies are warranted to characterize MAC-PD and its treatment in veterans without HIV who reside in underresourced urban communities in the US.
Authors: Sanja Stanojevic; Brian L Graham; Brendan G Cooper; Bruce R Thompson; Kim W Carter; Richard W Francis; Graham L Hall Journal: Eur Respir J Date: 2017-09-11 Impact factor: 16.671
Authors: Gina Oda; Mark A Winters; Susan M Pacheco; Monica K Sikka; Susan C Bleasdale; Bruce Dunn; Erin Boswell; Benjamin Winters; Amelia Bumsted; Jennifer Frisch; Mark Holodniy Journal: Infect Control Hosp Epidemiol Date: 2019-12-11 Impact factor: 3.254