| Literature DB >> 3544361 |
J P Coulaud, J Le Bras, S Matheron, B Moriniere, A G Saimot, J F Rossignol.
Abstract
Halofantrine is a 9-phenanthrenemethanol which is effective against multi-drug resistant strains of Plasmodium falciparum. It has been shown to be highly effective and extremely well tolerated in the treatment of imported cases of falciparum malaria in France. A total of 1,500 mg administered in three 500 mg doses at six-hour intervals results in a 100% cure rate in semi-immune subjects. This dosage should be repeated after 14 days to obtain the same cure rate in non-immune patients. Minor clinical side effects included epigastric pains, nausea and, in one case, a skin rash.Entities:
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Year: 1986 PMID： 3544361 DOI： 10.1016/0035-9203(86)90158-6
Source DB: PubMed Journal: Trans R Soc Trop Med Hyg ISSN： 0035-9203 Impact factor: 2.184