Tarun Khan1, C L Nawal1, P D Meena1, Aradhna Singh1.
Abstract
Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease with synovial joint inflammation; that culminates in progressive damage of the joint, especially with persistent inflammation. The neutrophils, lymphocytes, and platelets which are an important part of the immune system have a role in the control of inflammation, while also changing secondary to inflammation. Platelets have a significant role in inflammation and immune-modulation postulated by the presence of crosstalk between markers of coagulation and the inflammatory system. MATERIAL: This was a Hospital-based, cross-sectional and comparative study. The study was conducted at SMS Medical College and Hospital (Department of Medicine), Jaipur, Rajasthan, India. OBSERVATION: Most of the RA Cases were females (63.3%), while only 11 cases (36.7%) were males. Gender matched controls were selected, thus there were more females (63.3%), and 11 (36.7%) were males. The mean neutrophil percentage was higher among RA cases (66.23 ± 10.86%) as compared to controls (52.6 ± 7.23%).
CONCLUSION: The mean P: L ratio was higher among RA cases (184.88 ± 52.31) as compared to controls (115.56 ± 35.67). This difference in the P: L ratio among RA cases and controls was found to be statistically significant (p<0.001). The N: L ratio was higher among RA cases with active disease (3.31 ± 1.29) as compared to RA cases with remission (2.15 ± 0.74). This difference in N: L ratio concerning disease activity among RA cases were found to be statistically significant (p=0.007). © Journal of the Association of Physicians of India 2011.
Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease with synovial joint inflammation; that culminates in progressive damage of the joint, especially with persistent inflammation. The neutrophils, lymphocytes, and platelets which are an important part of the immune system have a role in the control of inflammation, while also changing secondary to inflammation. Platelets have a significant role in inflammation and immune-modulation postulated by the presence of crosstalk between markers of coagulation and the inflammatory system. MATERIAL: This was a Hospital-based, cross-sectional and comparative study. The study was conducted at SMS Medical College and Hospital (Department of Medicine), Jaipur, Rajasthan, India. OBSERVATION: Most of the RA Cases were females (63.3%), while only 11 cases (36.7%) were males. Gender matched controls were selected, thus there were more females (63.3%), and 11 (36.7%) were males. The mean neutrophil percentage was higher among RA cases (66.23 ± 10.86%) as compared to controls (52.6 ± 7.23%).
CONCLUSION: The mean P: L ratio was higher among RA cases (184.88 ± 52.31) as compared to controls (115.56 ± 35.67). This difference in the P: L ratio among RA cases and controls was found to be statistically significant (p<0.001). The N: L ratio was higher among RA cases with active disease (3.31 ± 1.29) as compared to RA cases with remission (2.15 ± 0.74). This difference in N: L ratio concerning disease activity among RA cases were found to be statistically significant (p=0.007). © Journal of the Association of Physicians of India 2011.
Entities:
Mesh：
Year: 2022
PMID： 35443426
Source DB: PubMed Journal: J Assoc Physicians India ISSN： 0004-5772