Literature DB >> 35442994

Retraction: Akt Regulates Drug-Induced Cell Death through Bcl-w Downregulation.

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Abstract

Entities:  

Year:  2022        PMID: 35442994      PMCID: PMC9020728          DOI: 10.1371/journal.pone.0267621

Source DB:  PubMed          Journal:  PLoS One        ISSN: 1932-6203            Impact factor:   3.240


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Following the publication of this article [1] and Expression of Concern [2], The Ohio State University informed PLOS of the outcome of an investigation into a figure in this article. The investigation by The Ohio State University concluded that western blot images were falsified in Figure 1B in this article [1] and/or Figure 1G in [3]. The investigation concluded: The β-actin panel in Figure 1B of this article [1] reports the same data as lanes 1 and 2 of the β-actin panel in Figure 1G of [3], despite representing different experimental conditions. Lanes 1, 2 of the Akt panel in Figure 1B of this article [1] report the same data as lanes 2, 3 of the β-actin panel in Figure 1G of [3], despite representing different experimental conditions. Concerns with Figure 1B had previously been noted in the Expression of Concern [2] and an Editor’s Comment posted on [1] by the PLOS ONE Editors on 7th Feb 2020. The corresponding author previously informed the journal that the original blots for Figure 1B were no longer available, and that the images in Figure 1B of [1] and Figure 1G of [3] were not the same. The information provided by The Ohio State University supports concerns raised previously regarding the reliability and reuse of image data in Figure 1B. Therefore, in accordance with PLOS policy and COPE retraction guidelines, the PLOS ONE Editors retract this article. In response to this retraction decision, the corresponding author and first author re-iterated that they do not have raw data underlying this figure, that institutional policy required data to be retained for only five years following publication, and that the investigation by The Ohio State University is being contested. MG and GC did not agree with the retraction. All other authors either did not respond directly or could not be reached.
  3 in total

1.  miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation.

Authors:  Michela Garofalo; Gianpiero Di Leva; Giulia Romano; Gerard Nuovo; Sung-Suk Suh; Apollinaire Ngankeu; Cristian Taccioli; Flavia Pichiorri; Hansjuerg Alder; Paola Secchiero; Pierluigi Gasparini; Arianna Gonelli; Stefan Costinean; Mario Acunzo; Gerolama Condorelli; Carlo Maria Croce
Journal:  Cancer Cell       Date:  2009-12-08       Impact factor: 31.743

2.  Expression of Concern: Akt Regulates Drug-Induced Cell Death through Bcl-w Downregulation.

Authors: 
Journal:  PLoS One       Date:  2019-03-19       Impact factor: 3.240

3.  Akt regulates drug-induced cell death through Bcl-w downregulation.

Authors:  Michela Garofalo; Cristina Quintavalle; Ciro Zanca; Assunta De Rienzo; Giulia Romano; Mario Acunzo; Loredana Puca; Mariarosaria Incoronato; Carlo M Croce; Gerolama Condorelli
Journal:  PLoS One       Date:  2008-12-30       Impact factor: 3.240

  3 in total
  1 in total

1.  Exclusive: investigators found plagiarism and data falsification in work from prominent cancer lab.

Authors:  Richard Van Noorden
Journal:  Nature       Date:  2022-07       Impact factor: 69.504

  1 in total

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