Ryuichiro Sato1,2, Masaya Oikawa3, Tetsuya Kakita3, Takaho Okada3, Tomoya Abe3, Takashi Yazawa3, Haruyuki Tsuchiya3, Naoya Akazawa3, Shingo Yoshimachi3, Tetsuya Ohira4, Yoshihiro Harada4, Haruka Okano4, Kei Ito4, Takashi Tsuchiya3. 1. Department of Gastroenterological Surgery, Sendai City Medical Center Sendai Open Hospital, 5-22-1 Tsurugaya, Miyagino-ku, Sendai, 983-0824, Japan. rsato-thk@umin.ac.jp. 2. Department of Surgery, Japanese Red Cross Sendai Hospital, 2-43-3 Yagiyama hon-cho, Taihaku-ku, Sendai, 982-8501, Japan. rsato-thk@umin.ac.jp. 3. Department of Gastroenterological Surgery, Sendai City Medical Center Sendai Open Hospital, 5-22-1 Tsurugaya, Miyagino-ku, Sendai, 983-0824, Japan. 4. Department of Gastroenterology, Sendai City Medical Center Sendai Open Hospital, 5-22-1 Tsurugaya, Miyagino-ku, Sendai, 983-0824, Japan.
Abstract
PURPOSE: The prognostic significance of the mean corpuscular volume (MCV) and red cell distribution width (RDW) in patients with malignancy have not been intensely investigated and are largely overlooked. We, therefore, investigated the clinical significance of MCV and RDW in non-metastatic obstructive colorectal cancer (OCRC) patients with a self-expandable metallic stent inserted as a bridge to curative surgery. METHODS: Eighty-five pathological stage II and III OCRC patients were retrospectively evaluated. The associations of the preoperative MCV and RDW values with short- and long-term outcomes were examined. RESULTS: There were 50 males and 35 females, and the median age was 71 years old. The median interval between stenting and surgery was 17 days, and the median postoperative hospital stay was 16 days. Fifty-six patients were in the MCV ≥ 87 group, and 47 were in the RDW ≥ 13.8 group. Multivariate analyses revealed the MCV ≥ 87 status to be independently associated with a poor relapse-free survival (hazard ratio [HR] = 4.70, 95% confidence interval [CI] 1.52-14.58, P = 0.007). The RDW ≥ 13.8% was an independent predictor of postoperative infectious complications (HR = 7.28, 95% CI 1.24-42.70, P = 0.028). CONCLUSION: The MCV and RDW are simple but strong predictors of postoperative outcomes in OCRC patients.
PURPOSE: The prognostic significance of the mean corpuscular volume (MCV) and red cell distribution width (RDW) in patients with malignancy have not been intensely investigated and are largely overlooked. We, therefore, investigated the clinical significance of MCV and RDW in non-metastatic obstructive colorectal cancer (OCRC) patients with a self-expandable metallic stent inserted as a bridge to curative surgery. METHODS: Eighty-five pathological stage II and III OCRC patients were retrospectively evaluated. The associations of the preoperative MCV and RDW values with short- and long-term outcomes were examined. RESULTS: There were 50 males and 35 females, and the median age was 71 years old. The median interval between stenting and surgery was 17 days, and the median postoperative hospital stay was 16 days. Fifty-six patients were in the MCV ≥ 87 group, and 47 were in the RDW ≥ 13.8 group. Multivariate analyses revealed the MCV ≥ 87 status to be independently associated with a poor relapse-free survival (hazard ratio [HR] = 4.70, 95% confidence interval [CI] 1.52-14.58, P = 0.007). The RDW ≥ 13.8% was an independent predictor of postoperative infectious complications (HR = 7.28, 95% CI 1.24-42.70, P = 0.028). CONCLUSION: The MCV and RDW are simple but strong predictors of postoperative outcomes in OCRC patients.
Authors: Femke J Amelung; Thijs A Burghgraef; Pieter J Tanis; Jeanin E van Hooft; Frank Ter Borg; Peter D Siersema; Willem A Bemelman; Esther C J Consten Journal: Crit Rev Oncol Hematol Date: 2018-09-04 Impact factor: 6.312
Authors: Jeanin E van Hooft; Joyce V Veld; Dirk Arnold; Regina G H Beets-Tan; Simon Everett; Martin Götz; Emo E van Halsema; James Hill; Gianpiero Manes; Soren Meisner; Eduardo Rodrigues-Pinto; Charles Sabbagh; Jo Vandervoort; Pieter J Tanis; Geoffroy Vanbiervliet; Alberto Arezzo Journal: Endoscopy Date: 2020-04-07 Impact factor: 10.093
Authors: Davor Kust; Marko Lucijanic; Kristina Urch; Ivan Samija; Ivana Celap; Ivan Kruljac; Marin Prpic; Ivica Lucijanic; Neven Matesa; Ante Bolanca Journal: QJM Date: 2017-06-01
Authors: Igor Braga Ribeiro; Wanderley Marques Bernardo; Bruno da Costa Martins; Diogo Touriani Hourneau de Moura; Elisa Ryoka Baba; Iatagan Rocha Josino; Nelson Tomio Miyahima; Martin Andrés Coronel Cordero; Thiago Arantes de Carvalho Visconti; Edson Ide; Paulo Sakai; Eduardo Guimarães Hourneau de Moura Journal: Endosc Int Open Date: 2018-05-08