Barbara H Bardenheier1,2, Linda Resnik3,4,5,6, Eric Jutkowitz3,5, Stefan Gravenstein3,5,7. 1. Department of Health Services, Policy, and Practice, Brown University School of Public Health, 121 S. Main Street Box G-S121-6, Providence, RI, 02912, USA. Barbara_bardenheier@brown.edu. 2. Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA. Barbara_bardenheier@brown.edu. 3. Department of Health Services, Policy, and Practice, Brown University School of Public Health, 121 S. Main Street Box G-S121-6, Providence, RI, 02912, USA. 4. Center of Innovation in Long-Term Services and Supports, Providence, RI, USA. 5. Veterans Affairs Medical Center, Providence, RI, USA. 6. Center for Neurorestoration and Neurotechnology, Providence Veterans Affairs Medical Center, Providence, RI, USA. 7. Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
Abstract
BACKGROUND: Even small improvements in modifiable Alzheimer's disease and related dementias (ADRD) risk factors could lead to a substantial reduction of dementia cases. AIMS: To determine if self-reported functional limitation associates with ADRD symptoms 4-18 years later. METHODS: We conducted a prospective longitudinal study using the Health and Retirement Study of adults aged 51-59 years in 1998 without symptoms of ADRD by 2002 and followed them to 2016. Main exposure variables were difficulty with activities of daily living, mobility, large muscle strength, gross motor and upper limb activities. The outcome was incident ADRD identified by the Lange-Weir algorithm, death, or alive without ADRD. We fit two GEE multinomial models for each measure: (1) baseline measure of function and (2) change in function over time. RESULTS: In the model with baseline only and outcome, only difficulty with mobility associated with future ADRD across levels of difficulty with near dose-response effect (risk ratios (RR) difficulty with 1-5 functions respectively, compared with no difficulty: 1.82; 2.70; 1.73 2.81; 4.03). Mobility also significantly associated with ADRD when allowing for change over time among those with 3, 4 or 5 versus no mobility limitations (RR 1.76; 2.36; 2.37). DISCUSSION: The results infer that an adult in midlife reporting difficulty with mobility as well as those with no mobility limitations in midlife but who later report severe limitations may be at increased risk of incident ADRD. CONCLUSIONS: Self-reported measures of mobility limitation may be early indicators of ADRD and may be useful for public health planning.
BACKGROUND: Even small improvements in modifiable Alzheimer's disease and related dementias (ADRD) risk factors could lead to a substantial reduction of dementia cases. AIMS: To determine if self-reported functional limitation associates with ADRD symptoms 4-18 years later. METHODS: We conducted a prospective longitudinal study using the Health and Retirement Study of adults aged 51-59 years in 1998 without symptoms of ADRD by 2002 and followed them to 2016. Main exposure variables were difficulty with activities of daily living, mobility, large muscle strength, gross motor and upper limb activities. The outcome was incident ADRD identified by the Lange-Weir algorithm, death, or alive without ADRD. We fit two GEE multinomial models for each measure: (1) baseline measure of function and (2) change in function over time. RESULTS: In the model with baseline only and outcome, only difficulty with mobility associated with future ADRD across levels of difficulty with near dose-response effect (risk ratios (RR) difficulty with 1-5 functions respectively, compared with no difficulty: 1.82; 2.70; 1.73 2.81; 4.03). Mobility also significantly associated with ADRD when allowing for change over time among those with 3, 4 or 5 versus no mobility limitations (RR 1.76; 2.36; 2.37). DISCUSSION: The results infer that an adult in midlife reporting difficulty with mobility as well as those with no mobility limitations in midlife but who later report severe limitations may be at increased risk of incident ADRD. CONCLUSIONS: Self-reported measures of mobility limitation may be early indicators of ADRD and may be useful for public health planning.
Authors: Francine Grodstein; Chiang-Hua Chang; Ana W Capuano; Melinda C Power; David X Marquez; Lisa L Barnes; David A Bennett; Bryan D James; Julie P W Bynum Journal: J Gerontol A Biol Sci Med Sci Date: 2022-06-01 Impact factor: 6.591
Authors: Roderick A Corriveau; Walter J Koroshetz; Jordan T Gladman; Sophia Jeon; Debra Babcock; David A Bennett; S Thomas Carmichael; Susan L-J Dickinson; Dennis W Dickson; Marian Emr; Howard Fillit; Steven M Greenberg; Michael L Hutton; David S Knopman; Jennifer J Manly; Karen S Marder; Claudia S Moy; Creighton H Phelps; Paul A Scott; William W Seeley; Beth-Anne Sieber; Nina B Silverberg; Margaret L Sutherland; Angela Taylor; Christine L Torborg; Salina P Waddy; Amelie K Gubitz; David M Holtzman Journal: Neurology Date: 2017-11-08 Impact factor: 9.910
Authors: Aron S Buchman; Robert S Wilson; Patricia A Boyle; Julia L Bienias; David A Bennett Journal: Neuroepidemiology Date: 2007-10-08 Impact factor: 3.282
Authors: Gill Livingston; Andrew Sommerlad; Vasiliki Orgeta; Sergi G Costafreda; Jonathan Huntley; David Ames; Clive Ballard; Sube Banerjee; Alistair Burns; Jiska Cohen-Mansfield; Claudia Cooper; Nick Fox; Laura N Gitlin; Robert Howard; Helen C Kales; Eric B Larson; Karen Ritchie; Kenneth Rockwood; Elizabeth L Sampson; Quincy Samus; Lon S Schneider; Geir Selbæk; Linda Teri; Naaheed Mukadam Journal: Lancet Date: 2017-07-20 Impact factor: 202.731