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Literature DB >> 35437788

The blood-brain barrier-a metabolic ecosystem.

Abstract

A functional blood-brain barrier relies on a tightly controlled interplay between endothelial cells, pericytes, and astrocytes, which together form the neurovascular unit. Recent work by Lee et al (2022) discovers endothelial cell-derived lactate as a crucial metabolic fuel for brain pericytes, revealing a new way of CNS vascular communication that links nutrient metabolism to blood-brain barrier function.

Entities: Chemical

Mesh：

Year: 2022 PMID： 35437788 PMCID： PMC9058533 DOI： 10.15252/embj.2022111189

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 14.012

11 in total

Review 1. Vascular heterogeneity and specialization in development and disease.

Authors: Michael Potente; Taija Mäkinen
Journal: Nat Rev Mol Cell Biol Date: 2017-05-24 Impact factor: 94.444

2. Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy.

Authors: Anna Rita Cantelmo; Lena-Christin Conradi; Aleksandra Brajic; Jermaine Goveia; Joanna Kalucka; Andreas Pircher; Pallavi Chaturvedi; Johanna Hol; Bernard Thienpont; Laure-Anne Teuwen; Sandra Schoors; Bram Boeckx; Joris Vriens; Anna Kuchnio; Koen Veys; Bert Cruys; Lise Finotto; Lucas Treps; Tor Espen Stav-Noraas; Francesco Bifari; Peter Stapor; Ilaria Decimo; Kim Kampen; Katrien De Bock; Guttorm Haraldsen; Luc Schoonjans; Ton Rabelink; Guy Eelen; Bart Ghesquière; Jalees Rehman; Diether Lambrechts; Asrar B Malik; Mieke Dewerchin; Peter Carmeliet
Journal: Cancer Cell Date: 2016-11-17 Impact factor: 31.743

3. Endothelium-derived lactate is required for pericyte function and blood-brain barrier maintenance.

Authors: Heon-Woo Lee; Yanying Xu; Xiaolong Zhu; Cholsoon Jang; Woosoung Choi; Hosung Bae; Weiwei Wang; Liqun He; Suk-Won Jin; Zoltan Arany; Michael Simons
Journal: EMBO J Date: 2022-03-03 Impact factor: 14.012

4. The blood-brain barrier-a metabolic ecosystem.

Authors: Marco Castro; Michael Potente
Journal: EMBO J Date: 2022-04-19 Impact factor: 14.012

Review 5. Establishment and Dysfunction of the Blood-Brain Barrier.

Authors: Zhen Zhao; Amy R Nelson; Christer Betsholtz; Berislav V Zlokovic
Journal: Cell Date: 2015-11-19 Impact factor: 41.582

Review 6. The Science and Translation of Lactate Shuttle Theory.

Authors: George A Brooks
Journal: Cell Metab Date: 2018-04-03 Impact factor: 27.287

7. pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise.

Authors: Anita Reddy; Luiz H M Bozi; Omar K Yaghi; Evanna L Mills; Haopeng Xiao; Hilary E Nicholson; Margherita Paschini; Joao A Paulo; Ryan Garrity; Dina Laznik-Bogoslavski; Julio C B Ferreira; Christian S Carl; Kim A Sjøberg; Jørgen F P Wojtaszewski; Jacob F Jeppesen; Bente Kiens; Steven P Gygi; Erik A Richter; Diane Mathis; Edward T Chouchani
Journal: Cell Date: 2020-09-17 Impact factor: 41.582

8. Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity.

Authors: Koen Veys; Zheng Fan; Moheb Ghobrial; Ann Bouché; Melissa García-Caballero; Kim Vriens; Nadine Vasconcelos Conchinha; Aline Seuwen; Felix Schlegel; Tatiane Gorski; Melissa Crabbé; Paola Gilardoni; Raphaela Ardicoglu; Johanna Schaffenrath; Cindy Casteels; Gino De Smet; Ilse Smolders; Koen Van Laere; E Dale Abel; Sarah-Maria Fendt; Aileen Schroeter; Joanna Kalucka; Anna Rita Cantelmo; Thomas Wälchli; Annika Keller; Peter Carmeliet; Katrien De Bock
Journal: Circ Res Date: 2020-05-14 Impact factor: 17.367

9. Metabolic regulation of gene expression by histone lactylation.

Authors: Di Zhang; Zhanyun Tang; He Huang; Guolin Zhou; Chang Cui; Yejing Weng; Wenchao Liu; Sunjoo Kim; Sangkyu Lee; Mathew Perez-Neut; Jun Ding; Daniel Czyz; Rong Hu; Zhen Ye; Maomao He; Y George Zheng; Howard A Shuman; Lunzhi Dai; Bing Ren; Robert G Roeder; Lev Becker; Yingming Zhao
Journal: Nature Date: 2019-10-23 Impact factor: 49.962

10. Control of endothelial quiescence by FOXO-regulated metabolites.

Authors: Jorge Andrade; Chenyue Shi; Ana S H Costa; Jeongwoon Choi; Jaeryung Kim; Anuradha Doddaballapur; Toshiya Sugino; Yu Ting Ong; Marco Castro; Barbara Zimmermann; Manuel Kaulich; Stefan Guenther; Kerstin Wilhelm; Yoshiaki Kubota; Thomas Braun; Gou Young Koh; Ana Rita Grosso; Christian Frezza; Michael Potente
Journal: Nat Cell Biol Date: 2021-04-01 Impact factor: 28.213

1 in total

1. The blood-brain barrier-a metabolic ecosystem.

Authors: Marco Castro; Michael Potente
Journal: EMBO J Date: 2022-04-19 Impact factor: 14.012

1 in total