| Literature DB >> 3543765 |
J L Andreyko, L A Marshall, D A Dumesic, R B Jaffe.
Abstract
Since the discovery and synthesis of gonadotropin-releasing hormone (GnRH) in 1971, numerous long-acting agonistic and antagonistic analogs have been synthesized. Agonistic analogs were found to desensitize pituitary GnRH receptors with chronic use, resulting in decreased gonadotropin secretion and a hypogonadal state. These analogs are being investigated as potential contraceptives and in the treatment of several conditions in which decreased gonadal steroid production is desired. Substantial progress has been made in these areas. The purpose of this review is to provide the clinician with data regarding the potential clinical utility of this class of peptides.Entities:
Keywords: Androgens; Animals, Laboratory; Behavior; Biology; Cancer--men; Clinical Research; Contraception; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive Agents, Male; Contraceptive Mode Of Action; Dermatological Effects; Diseases; Economic Factors; Endocrine System; Endometrial Effects; Endometritis; Endometrium; Family Planning; Follicle Stimulating Hormone; Genital Effects, Female; Genitalia; Genitalia, Female; Gonadotropins; Gonadotropins, Pituitary; Hair Diseases; Hirsutism; Hormones; In Vitro; Infections; Literature Review; Luteinizing Hormone; Menstruation Disorders; Neoplasms; Ovulation; Ovulation Suppression; Physiology; Pituitary Hormone Releasing Hormones--side effects; Psychological Factors; Reproduction; Reproductive Control Agents; Reproductive Tract Infections; Research And Development; Research Methodology; Sex Behavior; Signs And Symptoms; Technology; Treatment; Urogenital Effects; Urogenital System; Uterine Effects; Uterus
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Year: 1987 PMID： 3543765
Source DB: PubMed Journal: Obstet Gynecol Surv ISSN： 0029-7828 Impact factor: 2.347