Literature DB >> 3543412

Vaginal immunization against induced cystitis in monkeys.

D T Uehling, W J Hopkins, J Jensen, E Balish.   

Abstract

Cynomolgus monkeys received either vaginal immunization with formalin-killed E. coli or vaginal instillation of excipient without the bacteria. At 2, 7, 14 and 21 days after induction of a urinary tract infection with live E. coli, immunized monkeys showed enhanced clearance of bacteriuria compared to non-immunized controls. Immunized monkeys also showed increased levels of urinary anti-E. coli IgA and IgG after the immunizing and infecting procedures. Induction of heightened local immunity by vaginal immunization may lessen host susceptibility to urinary tract infections.

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Year:  1987        PMID： 3543412     DOI： 10.1016/s0022-5347(17)44015-8

Source DB:  PubMed          Journal:  J Urol        ISSN： 0022-5347            Impact factor:   7.450


  9 in total

1.  Treatment of mice with staphylococcal enterotoxin B enhances resolution of an induced Escherichia coli urinary tract infection and stimulates production of proinflammatory cytokines.

Authors:  M D Morin; W J Hopkins
Journal:  Infect Immun       Date:  1998-06       Impact factor: 3.441

Review 2.  Models of inflammation of the lower urinary tract.

Authors:  Dale E Bjorling; Zun-Yi Wang; Wade Bushman
Journal:  Neurourol Urodyn       Date:  2011-06       Impact factor: 2.696

3.  Secretory immunoglobulin A and inhibitory activity of bacterial adherence to epithelial cells in urine from patients with urinary tract infections.

Authors:  A Trinchieri; L Braceschi; D Tiranti; S Dell'Acqua; A Mandressi; E Pisani
Journal:  Urol Res       Date:  1990

4.  Local and systemic antibody responses accompany spontaneous resolution of experimental cystitis in cynomolgus monkeys.

Authors:  W J Hopkins; D T Uehling; E Balish
Journal:  Infect Immun       Date:  1987-09       Impact factor: 3.441

Review 5.  Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections.

Authors:  Valerie P O'Brien; Thomas J Hannan; Hailyn V Nielsen; Scott J Hultgren
Journal:  Microbiol Spectr       Date:  2016-02

6.  Lipopolysaccharide-responder and nonresponder C3H mouse strains are equally susceptible to an induced Escherichia coli urinary tract infection.

Authors:  W Hopkins; A Gendron-Fitzpatrick; D O McCarthy; J E Haine; D T Uehling
Journal:  Infect Immun       Date:  1996-04       Impact factor: 3.441

Review 7.  Waging war against uropathogenic Escherichia coli: winning back the urinary tract.

Authors:  Kelsey E Sivick; Harry L T Mobley
Journal:  Infect Immun       Date:  2009-11-16       Impact factor: 3.441

8.  Local immune response to upper urinary tract infections in children.

Authors:  Anu Kantele; Nina Palkola; Heikki Arvilommi; Olli Honkinen; Timo Jahnukainen; Jussi Mertsola; Jussi M Kantele
Journal:  Clin Vaccine Immunol       Date:  2008-01-09

9.  Bacterial cystitis is accompanied by increased peripheral thermal sensitivity in mice.

Authors:  Dale E Bjorling; Zun-Yi Wang; Kyle Boldon; Wade Bushman
Journal:  J Urol       Date:  2007-12-20       Impact factor: 7.450
  9 in total

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