The efficacy and safety of antibiotics and glucocorticoids in the treatment of elderly patients with chronic obstructive emphysema: systematic review and meta-analysis.

Background: To systematically evaluate the efficacy and safety of inhaled corticosteroids (ICS) combined with antibiotics in the treatment of elderly chronic obstructive pulmonary disease (COPD) patients, and to provide some reference for the optimization of clinical treatment regimen for elderly COPD patients.
Methods: Combination of perfect search and keywords from the Chinese and foreign language databases, and the Cochrane Collaboration Center provided Review Manger 5.2 software [Cochrane Information Management System (IMS)] for statistical analysis, and the risk ratio (RR) of dichotic variables was adopted. RR and 95% confidence interval (95% CI) were used as efficacy and side effects analysis statistics in metaanalysis.
Results: After independent screening by two researchers, 18 studies were included into the meta-analysis. After data analysis and statistics, the results of meta-analysis showed that the observation group (glucocorticoid combined with antibiotic treatment) and the control group (glucocorticoid therapy) first second forced expiratory volume (FEV1%) expected value (OR =1.21; 95% CI: 0.11-2.32; P=0.03), and 6-min walking distances (6-MWDs) (OR =12.92; 95% CI: 4.61-21.22; P=0.002), the COPD Assessment Test (CAT) score (OR =3.08; 95% CI: 2.58-3.57; P<0.00001) the improvement was statistically significant; incidence of adverse reactions (OR =1.24; 95% CI: 0.58-2.67; P=0.58), the incidence of acute exacerbation (OR =0.65; 95% CI: 0.39-1.08; P=0.10), FEV1 (OR =0.07; 95% CI: 0.01-0.15; P=0.09). There was no statistical difference. Discussion: The combination of glucocorticoids and antibiotics in elderly patients with stable COPD can significantly improve their lung function and exercise ability with minimal adverse reactions. 2022 Annals of Translational Medicine. All rights reserved.

Introduction

Chronic obstructive pulmonary disease (COPD) is a preventable and treatable chronic inflammatory disease of the airways characterized by airflow restriction (1). In the course of COPD, patients often have lower respiratory tract infection and other acute exacerbation of the disease. Frequent exacerbations can reduce the quality of life or patients, aggravate airway inflammation, further deteriorate lung function, and increase the hospitalization rate and mortality. Although studies (2,3) have demonstrated the presence of bacterial colonization (primarily haemophilus influenzae) in the airway of patients with stable COPD, antibiotic prophylaxis in patients with stable COPD is associated with acute exacerbation. There is consensus that antibiotic prophylaxis is not recommended for patients with stable COPD. The need for antibiotic treatment in acute exacerbation of COPD (AECOPD) has been controversial. However, the results of studies in the past 10 years have shown that infection is the main cause of AECOPD. Bacterial and atypical pathogen infection play an important role in the pathogenesis of AECOPD. In AECOPD patients with antimicrobial indications, aggressive and highly effective antibiotic treatment can rapidly relieve clinical symptoms, shorten the course of acute exacerbations, reduce the bacterial load in the airway, and delay acute exacerbations. During the course of AECOPD, the patient’s cough, expectoration, shortness of breath, and wheezing are aggravated in the short term, the expectoration volume is increased, and the sputum is purulent or mucus purulent. These symptoms can be accompanied by fever and other inflammatory manifestations that are significantly aggravated. However, there is no unified definition and criteria for AECOPD. AECOPD was defined by the American Thoracic Society/European Respiratory Society in 2020 as dyspnea, cough, and/or expectoration beyond the usual variation in COPD patients requiring modifications to existing treatment. At present, the main symptoms of acute exacerbation and their categorization have been proposed by Canadian scholar. Of the symptoms identified, patients with three main symptoms are classified as type I; patients with only two major symptoms are classified as type II; and patients are classified as type III if they only have one major symptom and one of the following secondary symptoms: (I) respiratory infection within the past 5 days; (II) fever of unknown cause; (III) severe wheezing; (IV) cough aggravation; or (V) an increase in the respiratory rate or heart rate by 20% or more than usual. In general, AECOPD can be considered when COPD patients present with two of the above symptoms (at least one of which is the main symptom) for ≥2 days. The doctor will evaluate the elderly COPD patient’s condition comprehensively according to the degree of dyspnea, the degree of impaired lung function, the number of acute attacks in the year before the visit and whether there are complications, and formulate the corresponding treatment plan. Drugs included short-acting bronchodilators, short-acting β2 agonists, short-acting anticholinergic agents and aminophylline; long-acting bronchodilators are long-acting β2 agonists, long-acting anticholinergic agents and sustained-release theophylline. Inhaled corticosteroids and phosphodiesterase 4 inhibitors; expectorant such as ambroxol hydrochloride, acetylcysteine, carbocylsteine, etc. Antioxidants such as carboxymethylstan and N-acetylcysteine can reduce the number of acute exacerbations of disease. Bronchodilators are important treatment drugs to control COPD symptoms, and inhalation is the first choice.

The Global Initiative Guidelines for Chronic Obstructive Pulmonary Disease (GOLD) recommend inhaled glucocorticoids (ICS) in combination with long acting β2 somatic agonists LABA as maintenance therapy for moderate to severe COPD during stabilization. To a large extent, medical regimens have not achieved satisfactory results in the control of COPD progression. Recent studies (4,5) have shown that glucocorticoid therapy for respiratory diseases such as asthma and COPD has drug resistance in the human body, which is due to the decreased sensitivity of drugs for airway receptors. Increasing the dose may ameliorate the situation, but at the same time cause adverse effects and an increased economic burden as the dose increases, especially in developing countries. Appropriate antibiotic treatment can reduce the airway inflammation of patients with COPD, and is also beneficial to improve the lung function of COPD patients, reduce the role of acute exacerbation, and significantly reduce the adverse reactions. The main innovations of this study are as follows: (I) in addition to analyzing glucocorticoid combined with antibiotics in the treatment of COPD, we also further analyzed the mechanism of action of its treatment; (II) the literatures included in our study are the latest clinical trial data, and the statistical methods are more rigorous; (III) the criteria of the included studies are more strict, and the bias and heterogeneity analysis of the included literatures are strictly controlled.

Clinical trials have explored the efficacy of glucocorticoids and antibiotics, but there are controversies. Therefore, based on the existing literature, this study conducted a systematic and comprehensive evaluation of glucocorticoid combined with antibiotics in the treatment of elderly patients with COPD. We present the following article in accordance with the PRISMA reporting checklist (available at https://atm.amegroups.com/article/view/10.21037/atm-22-239/rc).

Methods

Inclusion criteria

Studies were included in the meta-analysis if they contained all of the following:

Subject investigated: the patient was in moderate and severe COPD stability (according to the GOLD grade), 40 years of age, did not have a history of acute exacerbation within 2 weeks before enrollment, and did not regularly use theophylline medication.

Intervention study: the observation group was treated with glucocorticoid combined with antibiotics, while the control group was treated with glucocorticoid alone. Patients received topical administration of the ICS compound and oral administration of antibiotics.

Outcomes: one or more of the first second forced expiratory volume (FEV1), FEV1 as a percentage of expected value (FEV1%, FEV1% expected, FEV), adverse reactions (palpitation, palpitation, arrhythmia, nausea, vomiting), acute exacerbation (acute deterioration of respiratory symptoms requiring additional treatment), 6-min walking distance (6MWD), COPD Assessment Test (CAT) score.

Study type: randomized, controlled, and parallel clinical studies (RCT).

Exclusion criteria

Studies were excluded from the meta-analysis if they included any of the following: (I) patients with bronchial asthma, bronchiectasis, cardiovascular disease, liver and renal function impairment, active tuberculosis, digestive disease, severe hypertension, hyperglycemia, systemic disease with serious harm, or uncontrolled mental illness; (II) cohort studies, recall reports, individual case reports, or reviews; or (III) repeat reporting of literature or literature with higher similarity.

Search strategy

The Cochrane databases were searched through PubMed, Embase, The Cochrane Library, CNKI database, Wanfang Database, VIP database, China Biomedical Literature Service System, and other databases. In addition to retrieving relevant authoritative databases, this study also performs retrieval and statistical analysis on some relevant data of Registers or Websites. The retrieval time limit was until October 2021. In order to improve the retrieval strategy, we browsed the necessary references to improve the retrieval method. English keywords were searched by superposition and mixture and were the following: antibiotics, chronic obstructive pulmonary disease, glucocorticoid, and budesonide.

Literature screening and data extraction

Through perfecting the system of evaluation in advance into the exclusion standard and data extraction, and made the corresponding form in the table is made after training learning related content, in the process of screening literature, extract data is expected to appear special circumstances, after discussion decision criterion, finally by two to participate in the system evaluation personnel is based on the literature retrieval model for independent early screening. Through preliminary reading literature title and abstract to qualify in this system by perfecting the system of evaluation in advance into the exclusion standard and data extraction, and made the corresponding form in the table is made after training learning related content, in the process of screening literature, extract data is expected to appear special circumstances, after discussion decision criterion. Finally, two participants in the system evaluation conducted an independent preliminary screening of the literature obtained according to the retrieval formula, and screened the literature titles and abstracts through preliminary reading.

Bias risk assessment

Studies included in the meta-analysis were reviewed by a third person using the complete RCTs bias evaluation system from the Cochrane 5.1.0 system evaluation manual. The bias risk assessment examined the following components of each study: whether the method was random, the allocation scheme, blindness, lost visit and exit, whether the study contained selective reports of study results, and another six risk evaluation criteria ().

Figure 1

Literature quality evaluation chart. (A) Risk of bias graph; (B) risk of bias summary.

Figure 2

Funnel plot showing the literature publication bias. (A) Funnel plot of FEV1; (B) funnel plot of FEV1%. SE, standard error; OR, odds ratio; FEV1, the first second forced expiratory volume.

Data processing

There were differences in units of measurement in different documents. To overcome this, the units were unified into an international general form according to the conversion method, and then the corresponding change values were calculated by extracting the FEV1, FEV1% expected value, 6MWD, and CAT score treatment.

Statistical analysis

The Cochrane Collaboration Center provided Review Manger 5.2 software [Cochrane Information Management System (IMS)] for statistical analysis, and the Risk ratio of dichotic variables was adopted. RR and 95% confidence interval (95% CI) were used as efficacy and side effects analysis statistics in meta analysis. The included studies were analyzed by chi-square tests, and the heterogeneity size was determined based on the size of the I2 values. I2<50% indicated that heterogeneity should be a fixed effect mode. When I2 was 50%, the heterogeneity was large. The source of heterogeneity was explored through sensitivity analysis. If there was statistical heterogeneity between studies without clinical heterogeneity, random effect models were used. Descriptive analysis was used when the heterogeneity between the two groups was too large or the sources of heterogeneity could not be found. When more than ten studies were included, we drew funnel plot to evaluate the publication bias.

Results

Results of literature

A total of 289 documents were obtained for the preliminary examination, and 120 relevant documents were imported into NoteExpress. All 169 articles were read, and from these 91 were excluded because they examined unstable COPD, had inconsistent administration, were non-prospective studies, or used unrelated outcome indicators (). Finally, 18 studies (6-23) contained 1,636 patients (). No significant publication bias was found in the literature included in this study ().

Figure 3

Flow chart of the literature screening.

Table 1

Basic clinical features of the 18 articles that were included in our study

Study	Cases (n)	Age	COPD classification	Intervention		Outcome	Treatment (months)
				Experimental group	Control group
Tong 2018	180	68.31±3.41	III	Glucocorticoid + antibiotics	Glucocorticoid	FEV1; FEV1 (%)	6
Vogelmeier 2018	120	61.60±8.59	III	Glucocorticoid + antibiotics	Glucocorticoid	FEV1; FEV1 (%)	12
Barstow C 2019	70	67.96±8.79	IV	Glucocorticoid + antibiotics	Glucocorticoid	FEV1; FEV1 (%)	5
Petite SE 2019	50	66.14±9.24	III	Glucocorticoid + antibiotics	Glucocorticoid	FEV1; FEV1 (%)	6
Balakrishnan 2020	120	68.03±4.53	III	Glucocorticoid + antibiotics	Glucocorticoid	FEV1; FEV1 (%)	6
Ferguson GT 2017	140	65.80±8.07	IV	Glucocorticoid + antibiotics	Glucocorticoid	FEV1; FEV1 (%)	12
Van Velzen 2017	99	62.51±6.51	III	Glucocorticoid + antibiotics	Glucocorticoid	FEV1 (%)	3
Engel B 2017	68	65.12±5.22	III	Glucocorticoid + antibiotics	Glucocorticoid	FEV1 (%)	3
Finch AP 2019	78	64.05±3.71	IV	Glucocorticoid + antibiotics	Glucocorticoid	FEV1 (%)	2
Rabe KF 2019	50	61.15±7.65	III	Glucocorticoid + antibiotics	Glucocorticoid	FEV1 (%)	2
Lipson DA 2020	45	63.25±2.65	III	Glucocorticoid + antibiotics	Glucocorticoid	FEV1 (%); 6MWD	12
Rabe KF 2020	78	62.22±4.15	III	Glucocorticoid + antibiotics	Glucocorticoid	FEV1 (%); 6MWD	3
Hansen H 2020	56	61.35±5.65	III	Glucocorticoid + antibiotics	Glucocorticoid	FEV1 (%); 6MWD	5
Faiz A 2020	68	68.15±5.61	III	Glucocorticoid + antibiotics	Glucocorticoid	FEV1 (%); 6MWD	12
Lee LA 2021	110	68.23±2.53	IV	Glucocorticoid + antibiotics	Glucocorticoid	FEV1 (%); 6MWD	6
Jenkins CR 2021	60	67.22±4.15	IV	Glucocorticoid + antibiotics	Glucocorticoid	FEV1; CAT	1
Hanania NA 2021	40	64.03±1.55	IV	Glucocorticoid + antibiotics	Glucocorticoid	FEV1; CAT	1
Qin R 2021	70	645.03±3.78	IV	Glucocorticoid + antibiotics	Glucocorticoid	FEV1; CAT	4

COPD, chronic obstructive pulmonary disease; FEV1, first second forced expiratory volume; 6MWD, 6-min walking distance; CAT, COPD Assessment Test.

FEV1% predicted value

A total of 12 of the included studies contained data on FEV1% predicted value. Due to the small degree of heterogeneity (I2=0%), the fixed-effect model was applied. Results showed that FEV1% predicted value in the glucocorticoid combined treatment group was better than that in the control group, and the difference was statistically significant (OR =2.00; 95% CI: 1.58–2.54; P<0.00001) ().

Figure 4

Meta-analysis of FEV1% predicted value. FEV1, first second forced expiratory volume.

FEV1

FEV1 was reported in 5 studies with low heterogeneity (I2=8%). After undertaking a sensitivity analysis, two highly heterogeneous literatures were excluded and the fixed effect model was used. Meta-analysis results showed that the improvement of FEV1 in the glucocorticoid and antibiotic combined treatment group was better than that in the control group. The difference was statistically significant (OR =1.68; 95% CI: 1.10–2.57; P=0.02) ().

Figure 5

Meta-analysis of FEV1. FEV1, first second forced expiratory volume.

Incidence of acute aggravation

A total of 8 studies were included, all of which lasted for 3 months or more. Due to the acceptable heterogeneity (I2=26%), the fixed-effect model was applied. Results showed that the incidence of acute exacerbations in the glucocorticoid combined with antibiotic treatment group was lower than that in the control group. The difference was statistically significant (OR =0.68; 95% CI: 0.52–0.90; P=0.007) ().

Figure 6

Meta-analysis of incidence of acute aggravation.

Adverse reactions

A total of 4 studies reported adverse events related to glucocorticoid combined with antibiotic therapy, including palpitations and nausea. Due to the small degree of heterogeneity (I2=0%), the fixed-effect model was applied. Results showed that the incidence of adverse reactions was statistically different between the glucocorticoid and antibiotic combination group and the control group (OR =0.51; 95% CI: 0.30–0.84; P=0.009) ().

Figure 7

Meta-analysis of adverse reactions.

6MWD

A total of 6 included studies contained data about 6MWD. Due to acceptable heterogeneity (I2=9%), the fixed effect model was used for analysis. Results showed that the improvement of 6MWD in patients treated with glucocorticoid combined with antibiotics was better than that in the control group, with a statistically significant difference (OR =1.52; 95% CI: 1.19–1.94; P=0.0007) ().

Figure 8

Meta-analysis of 6MWD. 6MWD, 6-min walking distance.

CAT score

A total of 6 studies were included, and the heterogeneity (I2=74%) was analyzed using fixed effect model. The improvement of the CAT score in the glucocorticoid combined with antibiotic treatment group was better than that in the control group, and the difference was statistically significant (OR =1.53; 95% CI: 1.13–2.07; P=0.006) ().

Figure 9

Meta-analysis of CAT score. CAT, COPD Assessment Test; COPD, chronic obstructive pulmonary disease.

Discussion

The pathogenesis of COPD gradually evolves from acute inflammation to chronic inflammation and to tissue remodeling, resulting in irreversible airflow obstruction (24). COPD has attracted worldwide interest because of its high prevalence, morbidity, and mortality, which pose great challenges to the healthcare system and the economy. Although there are still many controversial issues surrounding the treatment regimen of COPD, the current treatment direction is mainly to combat airway inflammation and diastolic bronchial delayed airflow limitations (25-28).

A large proportion of elderly patients have COPD and also have more difficulty during treatment. For such patients, more conservative drug treatment will be carried out (29). Effectively controlling the infection is a key part of treatment in elderly patients because they have reduced body function, poor immune ability, and are often more prone to infections (30). Antibiotics have a wide clinical application rate (31). They are also commonly used in the treatment of COPD. Antibiotic drugs can inhibit synthesis of the bacterial cell wall, which kills bacteria. However, bacteria can develop different degrees of resistance to antibiotics, so antibiotics may not always be effective and the assistance of other drugs is needed (32). Clinical antibiotics and glucocorticoids are often used. Glucosides inhibit steroid hormones, which can effectively inhibit the body’s immune response, have anti-toxicity and anti-inflammatory properties, and are mostly used in the clinical treatment of diseases for which there are insufficient antibiotics and anti-inflammatory drugs (33-35).

COPD is an abnormal inflammatory reaction mainly characterized by airway airflow restriction (36). Treatment often fails repeatedly, and patients with COPD can have a long disease course, especially in elderly patients who have other co-morbidities. In the process of COPD treatment, the application of antibiotics is the main measure to eliminate pathogenic bacteria and reduce symptoms. However, most patients have varying degrees of resistance to antibiotics. In view of this, this study observed that, on the application of antibiotics, methylprednisolone was added on the basis of sodium succinate, which is a glucocorticoid and has a strong anti-inflammatory and anti-shock effects, and inhibits immune response (37). In the diagnosis and treatment of COPD, glucocorticoid can reduce airway reactivity and relieve clinical symptoms by inhibiting the production and release of inflammatory cytokines (38). Our results also showed that the overall efficacy and lung function improvement in the observed group were significantly better than in the control group (39,40). Moreover, there were no serious adverse reactions, which further confirmed that treating COPD in elderly patients with a combination of glucocorticoids and antibiotics can better improve the lung function of patients (41). As medical professionals, we must recognize that the same disease affects younger and older people differently, and we must address this perceived impact and tailor and optimize treatment for each patient. Younger patients more frequently reported that COPD was extremely affecting their ability to perform tasks outside the home (37% vs. 22%) and to travel long distances (38% vs. 18%), and the effect of glucocorticoid combined with antibiotics in the treatment of young COPD patients is better than that of elderly COPD patients, the bronchial mucosa of young COPD patients is more sensitive to drugs, and the effect of bronchial smooth muscle relaxation is more obvious, the specific clinical manifestations are shorter medication cycle, higher symptom relief rate, fewer complications.

Limitations of this study were as follows: (I) literature inclusion had geographical limitations; (II) some studies did not employ randomized hidden assignment, blinded not described, could generate selection and operational bias; (III) most of the included RCT did not report specific randomized methods for inclusion into their studies; and (IV) some indicators showed publication bias.

Conclusions

In this study, the combined group was treated with antibiotics and glucocorticoids, and the levels of FEV1, FEV%, 6MWD, and CAT score in the combined group were better than those in the control group. The total clinical effective rate in the combination group was significantly higher than that in control group, with a statistically significant difference (P<0.05). Our meta-analysis showed that the combination of antibiotics and glucocorticoids in the treatment of elderly patients with COPD can improve the lung function of patients, effectively control infection, and ensure the best effect of available drugs.

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