The Impact of Personality Pathology Across Three Generations: Evidence from the St. Louis Personality and Intergenerational Network Study.

Personality disorder (PD) symptoms in a parent generation may confer risk for problems in future generations, but intergenerational transmission has not been studied beyond parent-child effects. We examined the generational transfer of risk associated with PDs using structural models of grandparent personality pathology and grandchild psychopathology among 180 adults (M age =66.9), 218 of their children (M age =41.2), and 337 of their grandchildren (M age =10.5). We found evidence for general and heterotypic domain-specific transmission. Specifically, broad grandparent personality pathology was associated with broad grandchild psychopathology (B=.15, 95% CI [-.01, .31]); at the domain level, grandparent internalizing personality pathology was associated with grandchild externalizing psychopathology (B =.06, 95% CI [.01, .12]). Neither association was significantly mediated by parental personality pathology. These findings indicate that personality pathology in one generation confers risk for psychopathology across subsequent generations. Such intergenerational transmission operates across broad, rather than specific (i.e., individual disorder) psychopathology domains.