Literature DB >> 3543227

Proteolytic enzyme activities of macrophages and lymphocytes in neurological diseases.

I Goto, N Shinno, Y Kuroiwa.   

Abstract

Studies showed a significant decrease in the macrophage neutral protease and lymphocyte acid protease activities in patients with multiple sclerosis in remission, a significantly decreased neutral protease activity in macrophages in patients with myasthenia gravis and a significantly decreased acid protease activity in macrophages and lymphocytes in patients with polymyositis. No remarkable abnormalities were found in patients with myotonic dystrophy. These results suggest that multiple sclerosis, myasthenia gravis and polymyositis have an abnormality in immunological function.

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Year:  1986        PMID： 3543227     DOI： 10.1007/BF00313926

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  8 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Peptide hydrolases in spinal cord and brain of the rabbit.

Authors:  S Serra; A Grynbaum; A Lajtha; N Marks
Journal:  Brain Res       Date:  1972-09-29       Impact factor: 3.252

3.  Mechanisms of lysosomal enzyme release from leukocytes exposed to immune complexes and other particles.

Authors:  G Weissmann; R B Zurier; P J Spieler; I M Goldstein
Journal:  J Exp Med       Date:  1971-09-01       Impact factor: 14.307

4.  Suppressor T-lymphocytes in multiple sclerosis: analysis of patients with acute relapsing and chronic progressive disease.

Authors:  D W Paty; L Kastrukoff; N Morgan; L Hiob
Journal:  Ann Neurol       Date:  1983-10       Impact factor: 10.422

5.  Proteolytic enzyme activities in mononuclear cells and granulocytes of patients with various neurological disorders.

Authors:  I Goto; N Shinno; Y Kuroiwa
Journal:  J Neurol Sci       Date:  1983-06       Impact factor: 3.181

6.  Pretreatment of plastic Petri dishes with fetal calf serum. A simple method for macrophage isolation.

Authors:  K Kumagai; K Itoh; S Hinuma; M Tada
Journal:  J Immunol Methods       Date:  1979       Impact factor: 2.303

7.  Inhibition of cathepsin D-type proteinase of macrophages by pepstatin, a specific pepsin inhibitor, and other substances.

Authors:  M H McAdoo; A M Dannenberg; C J Hayes; S P James; J H Sanner
Journal:  Infect Immun       Date:  1973-04       Impact factor: 3.441

8.  Disease activity markers in multiple sclerosis. Another look at suppressor cells defined by monoclonal antibodies OKT4, OKT5, and OKT8.

Authors:  G P Rice; D Finney; S L Braheny; R L Knobler; J C Sipe; M B Oldstone
Journal:  J Neuroimmunol       Date:  1984-04       Impact factor: 3.478
  8 in total
  1 in total

1.  Cathepsin D activity in human peripheral blood mononuclear leukocytes.

Authors:  C T Bever; K D Morgan; J N Whitaker
Journal:  Inflammation       Date:  1989-06       Impact factor: 4.092
  1 in total

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