Tiffany X Chen1, Chi-Ying R Lin1, Megan A Aumann1, Yan Yan1, Nadia Amokrane1, Natasha A Desai1, Hakmook Kang1, Daniel O Claassen1, Sheng-Han Kuo2. 1. From the Department of Neurology (T.X.C., N.A., N.A.D., S.-H.K.) and Initiative of Columbia Ataxia and Tremor (T.X.C., N.A., N.A.D., S.-H.K.), Columbia University Medical Center, New York, NY; Department of Biomedical Engineering (T.X.C.), Johns Hopkins University, Baltimore, MD; Department of Neurology (C.-Y.R.L.), Baylor College of Medicine, Houston, TX; Vanderbilt Brain Institute (M.A.A.), Department of Psychology, Vanderbilt University; and Departments of Neurology (M.A.A., D.O.C.) and Statistics (Y.Y., H.K.), Vanderbilt University Medical Center, Nashville, TN. 2. From the Department of Neurology (T.X.C., N.A., N.A.D., S.-H.K.) and Initiative of Columbia Ataxia and Tremor (T.X.C., N.A., N.A.D., S.-H.K.), Columbia University Medical Center, New York, NY; Department of Biomedical Engineering (T.X.C.), Johns Hopkins University, Baltimore, MD; Department of Neurology (C.-Y.R.L.), Baylor College of Medicine, Houston, TX; Vanderbilt Brain Institute (M.A.A.), Department of Psychology, Vanderbilt University; and Departments of Neurology (M.A.A., D.O.C.) and Statistics (Y.Y., H.K.), Vanderbilt University Medical Center, Nashville, TN. sk3295@cumc.columbia.edu.
Abstract
BACKGROUND AND OBJECTIVES: Individuals with cerebellar ataxia (CA) can develop impulsive behavioral symptoms, often resulting in negative interpersonal consequences, detrimentally affecting their quality of life. Limited evidence exists concerning impulsivity in CA and its associated behavioral changes. We assessed impulsive traits in CA using the Barratt Impulsivity Scale (BIS-11) and compared them with those of Parkinson disease (PD) to investigate the differences in the impulsive trait profiles between CA and PD. METHODS: We conducted a dual-center cross-sectional study with individuals with CA and PD enrolled through consecutive sampling from movement disorders clinics at Columbia University Medical Center and Vanderbilt University Medical Center, respectively. Age-matched controls were recruited at the respective institutions. Participants were excluded if they had prior or comorbid neurologic and psychiatric diseases known to be associated with impulsivity. All participants completed the BIS-11 questionnaire as a measure of impulsive traits. We used a general linear model and a least absolute shrinkage and selection operation regression to compare the total, subscale, and individual items of the BIS-11 scores between groups. Subgroup analyses were performed to isolate cerebellar contributions to impulsivity from potential effects of extracerebellar pathology and dopaminergic dysfunction or medications. RESULTS: A total of 190 participants-90 age-matched controls, 50 participants with CA, and 50 with PD-completed the assessments. Persons with CA reported 9.7% higher BIS-11 scores than controls (p < 0.001), while persons with PD reported 24.9% higher scores than controls (p < 0.001). In CA, the most affected domain of impulsivity was nonplanning. In contrast, persons with PD noted greater impulsivity across the nonplanning, attentional, and motor domains. DISCUSSION: Impulsivity in CA is uniquely driven by the nonplanning trait, unlike in PD. This suggests that the cerebellum and basal ganglia may differentially govern impulsive behaviors with the cerebellum contributing to the brain circuitry of impulsivity in a domain-specific manner.
BACKGROUND AND OBJECTIVES: Individuals with cerebellar ataxia (CA) can develop impulsive behavioral symptoms, often resulting in negative interpersonal consequences, detrimentally affecting their quality of life. Limited evidence exists concerning impulsivity in CA and its associated behavioral changes. We assessed impulsive traits in CA using the Barratt Impulsivity Scale (BIS-11) and compared them with those of Parkinson disease (PD) to investigate the differences in the impulsive trait profiles between CA and PD. METHODS: We conducted a dual-center cross-sectional study with individuals with CA and PD enrolled through consecutive sampling from movement disorders clinics at Columbia University Medical Center and Vanderbilt University Medical Center, respectively. Age-matched controls were recruited at the respective institutions. Participants were excluded if they had prior or comorbid neurologic and psychiatric diseases known to be associated with impulsivity. All participants completed the BIS-11 questionnaire as a measure of impulsive traits. We used a general linear model and a least absolute shrinkage and selection operation regression to compare the total, subscale, and individual items of the BIS-11 scores between groups. Subgroup analyses were performed to isolate cerebellar contributions to impulsivity from potential effects of extracerebellar pathology and dopaminergic dysfunction or medications. RESULTS: A total of 190 participants-90 age-matched controls, 50 participants with CA, and 50 with PD-completed the assessments. Persons with CA reported 9.7% higher BIS-11 scores than controls (p < 0.001), while persons with PD reported 24.9% higher scores than controls (p < 0.001). In CA, the most affected domain of impulsivity was nonplanning. In contrast, persons with PD noted greater impulsivity across the nonplanning, attentional, and motor domains. DISCUSSION: Impulsivity in CA is uniquely driven by the nonplanning trait, unlike in PD. This suggests that the cerebellum and basal ganglia may differentially govern impulsive behaviors with the cerebellum contributing to the brain circuitry of impulsivity in a domain-specific manner.
Authors: Robert S Eisinger; Bonnie M Scott; Anh Le; Elena M Torres Ponce; Joseph Lanese; Christopher Hundley; Brawn Nelson; Tasmeah Ravy; Janine Lopes; Sable Thompson; Sneha Sathish; Rebecca L O'Connell; Michael S Okun; Dawn Bowers; Aysegul Gunduz Journal: Sci Rep Date: 2020-08-10 Impact factor: 4.379