Literature DB >> 3542673

Induction of class II MHC antigens in vitro on pancreatic B cells isolated from BB/E rats.

R Walker, A Cooke, A J Bone, B M Dean, P van der Meide, J D Baird.   

Abstract

The ability of recombinant Interferon-gamma to induce class II expression in vitro on pancreatic islet B cells has been investigated by exposing islets isolated from BB/E and normal Wistar rats to Interferon-gamma and then staining successively with monoclonal antibodies specific for rat class II MHC antigens and insulin. Induction of class II expression was never observed on islet cells obtained from either normal Wistar rats or rats from the BB/E low diabetes incidence (less than 2%) subline. In contrast, pancreatic B cells from rats from the BB/E high diabetes incidence (60-70%) subline expressed class II antigen following culture with Interferon-gamma.

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Year:  1986        PMID： 3542673     DOI： 10.1007/BF00870286

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  8 in total

1.  Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas.

Authors:  R Pujol-Borrell; I Todd; M Doshi; D Gray; M Feldmann; G F Bottazzo
Journal:  Clin Exp Immunol       Date:  1986-07       Impact factor: 4.330

2.  What triggers autoimmunity?

Authors: 
Journal:  Lancet       Date:  1985-07-13       Impact factor: 79.321

3.  Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells.

Authors:  B M Dean; R Walker; A J Bone; J D Baird; A Cooke
Journal:  Diabetologia       Date:  1985-07       Impact factor: 10.122

4.  In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis.

Authors:  G F Bottazzo; B M Dean; J M McNally; E H MacKay; P G Swift; D R Gamble
Journal:  N Engl J Med       Date:  1985-08-08       Impact factor: 91.245

5.  Islet cell surface antibodies and lymphocyte antibodies in the spontaneously diabetic BB Wistar rat.

Authors:  T Dyrberg; A F Nakhooda; S Baekkeskov; A Lernmark; P Poussier; E B Marliss
Journal:  Diabetes       Date:  1982-03       Impact factor: 9.461

6.  Interferon-gamma enhances the expression of the major histocompatibility class I antigens on mouse pancreatic beta cells.

Authors:  I L Campbell; G H Wong; J W Schrader; L C Harrison
Journal:  Diabetes       Date:  1985-11       Impact factor: 9.461

7.  Interferon-gamma induces HLA-DR expression by thyroid epithelium.

Authors:  I Todd; R Pujol-Borrell; L J Hammond; G F Bottazzo; M Feldmann
Journal:  Clin Exp Immunol       Date:  1985-08       Impact factor: 4.330

8.  Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex.

Authors:  E Colle; R D Guttmann; T Seemayer
Journal:  J Exp Med       Date:  1981-10-01       Impact factor: 14.307
  8 in total
  8 in total

Review 1.  Treatment of an autoimmune disease with "classical" T cell veto: a proposal.

Authors:  U D Staerz; Y Qi
Journal:  J Clin Immunol       Date:  1999-07       Impact factor: 8.317

2.  Induction of class II MHC antigens on human and rodent islet parenchymal cells in vitro.

Authors:  J R Wright; P E Lacy; E R Unanue; V Hauptfeld
Journal:  Diabetologia       Date:  1987-06       Impact factor: 10.122

3.  Class I and II major histocompatibility complex gene product expression by a rat insulinoma cell line in vitro following exposure to gamma interferon.

Authors:  B Issa-Chergui; A Goldner-Sauvé; E Colle; G J Prud'homme; P H Lapchak; P H van der Meide; T A Seemayer
Journal:  Diabetologia       Date:  1988-09       Impact factor: 10.122

4.  Pancreatic NOD beta cells express MHC class II protein and the frequency of I-A(g7) mRNA-expressing beta cells strongly increases during progression to autoimmune diabetes.

Authors:  U Walter; T Toepfer; K E J Dittmar; K Kretschmer; J Lauber; S Weiss; G Servos; O Lechner; W A Scherbaum; S R Bornstein; H Von Boehmer; J Buer
Journal:  Diabetologia       Date:  2003-07-10       Impact factor: 10.122

Review 5.  Cytokines and autoimmunity.

Authors:  M G Cavallo; P Pozzilli; R Thorpe
Journal:  Clin Exp Immunol       Date:  1994-04       Impact factor: 4.330

Review 6.  Autoantigens in thyroid diseases.

Authors:  K Dawe; P Hutchings; B Champion; A Cooke; I Roitt
Journal:  Springer Semin Immunopathol       Date:  1993

7.  Major histocompatibility complex protein expression on pancreas and pancreatic islet endocrine cell subsets.

Authors:  I Lautenschlager; K Inkinen; E Taskinen; M A Charles; P Hayry
Journal:  Am J Pathol       Date:  1989-12       Impact factor: 4.307

8.  Aberrant expression of class II major histocompatibility complex molecules by B cells and hyperexpression of class I major histocompatibility complex molecules by insulin containing islets in type 1 (insulin-dependent) diabetes mellitus.

Authors:  A K Foulis; M A Farquharson; R Hardman
Journal:  Diabetologia       Date:  1987-05       Impact factor: 10.122
  8 in total

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