Literature DB >> 3542566

Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut.

J J Holst, C Orskov, O V Nielsen, T W Schwartz.   

Abstract

By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78-107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78-107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78-107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.

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Year:  1987        PMID： 3542566     DOI： 10.1016/0014-5793(87)81430-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  99 in total

1.  Glucagon-like peptide-1 modulates neurally evoked mucosal chloride secretion in guinea pig small intestine in vitro.

Authors:  Sara Baldassano; Guo-Du Wang; Flavia Mulè; Jackie D Wood
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Review 2.  Enhancing bowel adaptation in short bowel syndrome.

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3.  Antidiabetogenic action of truncated glucagon-like peptide-1 in mice.

Authors:  B Ahrén
Journal:  Endocrine       Date:  1995-05       Impact factor: 3.633

Review 4.  The structure and function of the glucagon-like peptide-1 receptor and its ligands.

Authors:  Dan Donnelly
Journal:  Br J Pharmacol       Date:  2012-05       Impact factor: 8.739

5.  Comparative effects of the endogenous agonist glucagon-like peptide-1 (GLP-1)-(7-36) amide and the small-molecule ago-allosteric agent "compound 2" at the GLP-1 receptor.

Authors:  Karen Coopman; Yan Huang; Neil Johnston; Sophie J Bradley; Graeme F Wilkinson; Gary B Willars
Journal:  J Pharmacol Exp Ther       Date:  2010-05-27       Impact factor: 4.030

Review 6.  Glucagon-like peptide 1 (GLP-1).

Authors:  T D Müller; B Finan; S R Bloom; D D'Alessio; D J Drucker; P R Flatt; A Fritsche; F Gribble; H J Grill; J F Habener; J J Holst; W Langhans; J J Meier; M A Nauck; D Perez-Tilve; A Pocai; F Reimann; D A Sandoval; T W Schwartz; R J Seeley; K Stemmer; M Tang-Christensen; S C Woods; R D DiMarchi; M H Tschöp
Journal:  Mol Metab       Date:  2019-09-30       Impact factor: 7.422

7.  Inhibitory effect of glucagon-like peptide-1 on small bowel motility. Fasting but not fed motility inhibited via nitric oxide independently of insulin and somatostatin.

Authors:  T Tolessa; M Gutniak; J J Holst; S Efendic; P M Hellström
Journal:  J Clin Invest       Date:  1998-08-15       Impact factor: 14.808

Review 8.  Emerging treatments for post-transplantation diabetes mellitus.

Authors:  Trond Jenssen; Anders Hartmann
Journal:  Nat Rev Nephrol       Date:  2015-04-28       Impact factor: 28.314

9.  Agonist-induced internalization and recycling of the glucagon-like peptide-1 receptor in transfected fibroblasts and in insulinomas.

Authors:  C Widmann; W Dolci; B Thorens
Journal:  Biochem J       Date:  1995-08-15       Impact factor: 3.857

10.  Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1.

Authors:  G G Holz; C A Leech; J F Habener
Journal:  J Biol Chem       Date:  1995-07-28       Impact factor: 5.157
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