Yan Yan1, Qiaoxia Ye1, Liguan Liu1. 1. Infectious Disease Department, The 910th Hospital of Chinese People's Liberation Army Quanzhou 362300, Fujian Province, China.
Abstract
OBJECTIVE: To explore the characteristics of pathogenic bacteria in intra-abdominal infection and the risk factors for septic shock in patients with liver cirrhosis. METHODS: This retrospective study analyzed the clinical data of patients with cirrhosis admitted to the Department of Infectious Diseases of the 910th Hospital of Chinese People's Liberation Army, who were divided into an intra-abdominal infection group (n=145) and non-infection group (n=100). We analyzed the risk factors for intra-abdominal infection in patients with liver cirrhosis, and further conducted bacterial culture for patients with intra-abdominal infection to investigate the distribution of pathogenic bacteria and analyzed the risk factors for septic shock. RESULTS: Multivariate regression analysis found that age (P=0.005), length of hospital stay (P=0.024), invasive operation (P=0.002), and hypoproteinemia (P=0.026) were risk factors for intra-abdominal infection in patients with cirrhosis. 65 of the 145 patients with intra-abdominal infection were tested to be pathogen-positive, with a positivity rate of 44.83%. A total of 118 strains were isolated from the samples of 65 patients with positive test results. Among the 118 strains, 74 of them were gram-negative bacteria (62.71%), 41 were gram-positive bacteria (34.75%), and 3 were fungus (2.54%). Multivariate regression analysis found that age (P=0.003), length of stay (P=0.001), invasive operations (P=0.024) and hypoproteinemia (P=0.001) were all risk factors for septic shock in patients with liver cirrhosis combined with intra-abdominal infection. CONCLUSION: Age, length of hospital stay, invasive operation, and hypoproteinemia are risk factors for intra-abdominal infection and septic shock in patients with cirrhosis, and gram-negative bacteria are the main pathogens in associated intra-abdominal infection. AJTR
OBJECTIVE: To explore the characteristics of pathogenic bacteria in intra-abdominal infection and the risk factors for septic shock in patients with liver cirrhosis. METHODS: This retrospective study analyzed the clinical data of patients with cirrhosis admitted to the Department of Infectious Diseases of the 910th Hospital of Chinese People's Liberation Army, who were divided into an intra-abdominal infection group (n=145) and non-infection group (n=100). We analyzed the risk factors for intra-abdominal infection in patients with liver cirrhosis, and further conducted bacterial culture for patients with intra-abdominal infection to investigate the distribution of pathogenic bacteria and analyzed the risk factors for septic shock. RESULTS: Multivariate regression analysis found that age (P=0.005), length of hospital stay (P=0.024), invasive operation (P=0.002), and hypoproteinemia (P=0.026) were risk factors for intra-abdominal infection in patients with cirrhosis. 65 of the 145 patients with intra-abdominal infection were tested to be pathogen-positive, with a positivity rate of 44.83%. A total of 118 strains were isolated from the samples of 65 patients with positive test results. Among the 118 strains, 74 of them were gram-negative bacteria (62.71%), 41 were gram-positive bacteria (34.75%), and 3 were fungus (2.54%). Multivariate regression analysis found that age (P=0.003), length of stay (P=0.001), invasive operations (P=0.024) and hypoproteinemia (P=0.001) were all risk factors for septic shock in patients with liver cirrhosis combined with intra-abdominal infection. CONCLUSION: Age, length of hospital stay, invasive operation, and hypoproteinemia are risk factors for intra-abdominal infection and septic shock in patients with cirrhosis, and gram-negative bacteria are the main pathogens in associated intra-abdominal infection. AJTR