Dayna A Johnson1, Kristen Knutson, Laura A Colangelo, Lauren Hale, Susan Redline, Mercedes Carnethon, Kiarri N Kershaw. 1. From the Department of Epidemiology (Johnson), Emory University Rollins School of Public Health, Emory University, Atlanta, Georgia; Division of Sleep and Circadian Disorders (Johnson, Redline), Brigham and Women's Hospital, Boston, Massachusetts; Department of Preventive Medicine (Colangelo, Carnethon, Kershaw) and Department of Neurology (Knutson), Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Family (Hale), Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York; and Division of Sleep Medicine (Redline), Harvard Medical School, Boston, Massachusetts.
Abstract
OBJECTIVE: Chronic exposure to stress is associated with metabolic syndrome (MetS), but the mechanism is unclear. We investigated the associations between chronic burden, sleep, and MetS in the Coronary Artery Risk Development in Young Adults Study. METHODS: Chronic burden was self-reported (2000-2001) according to experiences with stressors for longer than 6 months. Wrist actigraphy-measured sleep duration and sleep efficiency were collected for 6 days; sleep duration, sleep quality, and daytime sleepiness were self-reported (2003-2004). MetS was measured during the clinic visit, from 2005 to 2006. Multivariable logistic and Cox proportional hazard models were fit to determine the associations of interest. Mediation by sleep was assessed using the product of coefficients approach. RESULTS: Among participants ( n = 606), the average (standard deviation) age was 40 (3.6) years, 58% were female, and 43% were Black. The prevalences of chronic burden, short sleep (≤6 hours), and MetS were 35%, 43% and 20.5%, respectively. High versus low chronic burden was associated with shorter self-reported sleep duration and higher daytime sleepiness. Chronic burden was associated with 1.85 higher odds (95% confidence interval = 1.11-3.09) of MetS. Sleep characteristics were not associated with MetS. There was no evidence that sleep mediated the chronic burden-MetS relation. CONCLUSION: Burden of chronic stress may be an emerging novel risk factor for both poor sleep and MetS.
OBJECTIVE: Chronic exposure to stress is associated with metabolic syndrome (MetS), but the mechanism is unclear. We investigated the associations between chronic burden, sleep, and MetS in the Coronary Artery Risk Development in Young Adults Study. METHODS: Chronic burden was self-reported (2000-2001) according to experiences with stressors for longer than 6 months. Wrist actigraphy-measured sleep duration and sleep efficiency were collected for 6 days; sleep duration, sleep quality, and daytime sleepiness were self-reported (2003-2004). MetS was measured during the clinic visit, from 2005 to 2006. Multivariable logistic and Cox proportional hazard models were fit to determine the associations of interest. Mediation by sleep was assessed using the product of coefficients approach. RESULTS: Among participants ( n = 606), the average (standard deviation) age was 40 (3.6) years, 58% were female, and 43% were Black. The prevalences of chronic burden, short sleep (≤6 hours), and MetS were 35%, 43% and 20.5%, respectively. High versus low chronic burden was associated with shorter self-reported sleep duration and higher daytime sleepiness. Chronic burden was associated with 1.85 higher odds (95% confidence interval = 1.11-3.09) of MetS. Sleep characteristics were not associated with MetS. There was no evidence that sleep mediated the chronic burden-MetS relation. CONCLUSION: Burden of chronic stress may be an emerging novel risk factor for both poor sleep and MetS.
Authors: Wendy M Troxel; Daniel J Buysse; Karen A Matthews; Kevin E Kip; Patrick J Strollo; Martica Hall; Oliver Drumheller; Steven E Reis Journal: Sleep Date: 2010-12 Impact factor: 5.849
Authors: Diane S Lauderdale; Kristen L Knutson; Lijing L Yan; Paul J Rathouz; Stephen B Hulley; Steve Sidney; Kiang Liu Journal: Am J Epidemiol Date: 2006-06-01 Impact factor: 4.897
Authors: R K Simmons; K G M M Alberti; E A M Gale; S Colagiuri; J Tuomilehto; Q Qiao; A Ramachandran; N Tajima; I Brajkovich Mirchov; A Ben-Nakhi; G Reaven; B Hama Sambo; S Mendis; G Roglic Journal: Diabetologia Date: 2009-12-11 Impact factor: 10.122
Authors: Mercedes R Carnethon; Jia Pu; George Howard; Michelle A Albert; Cheryl A M Anderson; Alain G Bertoni; Mahasin S Mujahid; Latha Palaniappan; Herman A Taylor; Monte Willis; Clyde W Yancy Journal: Circulation Date: 2017-10-23 Impact factor: 29.690
Authors: Carmela Alcántara; Sanjay R Patel; Mercedes Carnethon; Sheila Castañeda; Carmen R Isasi; Sonia Davis; Alberto Ramos; Elva Arredondo; Susan Redline; Phyllis C Zee; Linda C Gallo Journal: SSM Popul Health Date: 2017-12