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Literature DB >> 35420492

In Vitro Bedaquiline and Clofazimine Susceptibility Testing in Mycobacterium abscessus.

Bettina Schulthess^1,2, Fatma Nur Akdoğan Kittana¹, Rico Hömke^1,2, Peter Sander^1,2.

Abstract

Bedaquiline and clofazimine are increasingly used to treat infections with Mycobacterium abscessus. We determined distributions of MICs by broth microdilution for bedaquiline and clofazimine for 61 M. abscessus clinical isolates using different media and incubation times. We show that incubation time and growth media critically influence the MIC. Our data will aid in defining future clinical breakpoints for in vitro susceptibility testing for bedaquiline and clofazimine in M. abscessus.

Entities: Chemical

Keywords: ECOFF; MIC; Mycobacterium abscessus; antibiotic susceptibility testing; bedaquiline; clofazimine; epidemiological cutoff

Mesh：

Substances：

Year: 2022 PMID： 35420492 PMCID： PMC9112946 DOI： 10.1128/aac.02346-21

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.938

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