| Literature DB >> 35419643 |
Victor Schwartz Hvingelby1,2, Carsten Reidies Bjarkam3, Tiit Illimar Mathiesen4,5, Frantz Rom Poulsen6,7, Morten Thingemann Bøtker8,9, Andreas Husted10, Anders Rosendal Korshoej8,11.
Abstract
After severe traumatic brain injury (sTBI) proteins, neurotrophic factors and inflammatory markers are released into the biofluids. This review and meta-analysis searched the literature for prognostic candidate cerebrospinal fluid markers and their relation to sTBI patient outcome. A systematic search of the literature was carried out across PubMed, EMBASE, PubMed Central (PMC), and Cochrane Central Library. Biomarker concentrations were related to the Glasgow Outcome Scale dichotomized into favorable and unfavorable outcomes. When a biomarker was reported in ≥ 3 studies, it was included in meta-analysis. The search returned 1527 articles. After full-text analysis, 54 articles were included, 34 from the search, and 20 from the reference lists. Of 9 biomarkers, 8 were significantly different compared to controls (IL-4, IL-6, IL-8, IL-10, TNFα, sFas, BDNF, and cortisol). Of these, 5 were significantly increased in sTBI patients with unfavorable outcome (IL-6, IL-8, IL-10, TNFα, and cortisol), compared to patients with favorable outcome. This review demonstrated a correlation between 5 biomarkers and clinical outcome in sTBI patients. The paucity of included studies, however, makes it difficult to extrapolate further on this finding.Entities:
Keywords: Biomarker; Glasgow Outcome Score; Severe traumatic brain injury; Theranostics; Traumatic brain injury
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Year: 2022 PMID： 35419643 DOI： 10.1007/s10143-022-01786-4
Source DB: PubMed Journal: Neurosurg Rev ISSN： 0344-5607 Impact factor: 2.800