Literature DB >> 35419483

Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma.

Mariana Cooke1,2.   

Abstract

In a recent study, our group identified RAC guanine nucleotide exchange factors (RAC-GEFs) driving motility signaling in KRAS mutant lung adenocarcinoma cells. The RAC-GEFs FARP1, ARHGEF39 and TIAM2 play fundamental roles in the formation of membrane ruffles in response to growth factor receptor stimulation.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  KRAS; RAC-GEF; lung adenocarcinoma; metastasis; tyrosine kinase receptor

Year:  2021        PMID： 35419483      PMCID： PMC8997262          DOI： 10.1080/23723556.2021.2013723

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Lung cancer.

Authors:  Roy S Herbst; John V Heymach; Scott M Lippman
Journal:  N Engl J Med       Date:  2008-09-25       Impact factor: 91.245

Review 2.  The Rac GTPase in Cancer: From Old Concepts to New Paradigms.

Authors:  Marcelo G Kazanietz; Maria J Caloca
Journal:  Cancer Res       Date:  2017-08-14       Impact factor: 12.701

3.  Cancer Statistics, 2021.

Authors:  Rebecca L Siegel; Kimberly D Miller; Hannah E Fuchs; Ahmedin Jemal
Journal:  CA Cancer J Clin       Date:  2021-01-12       Impact factor: 508.702

4.  FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma.

Authors:  Mariana Cooke; Gabriel Kreider-Letterman; Martin J Baker; Suli Zhang; Neil T Sullivan; Evgeniy Eruslanov; Martin C Abba; Silvia M Goicoechea; Rafael García-Mata; Marcelo G Kazanietz
Journal:  Cell Rep       Date:  2021-11-02       Impact factor: 9.995

Review 5.  Emerging Biological Principles of Metastasis.

Authors:  Arthur W Lambert; Diwakar R Pattabiraman; Robert A Weinberg
Journal:  Cell       Date:  2017-02-09       Impact factor: 41.582

6.  ARHGEF39 promotes tumor progression via activation of Rac1/P38 MAPK/ATF2 signaling and predicts poor prognosis in non-small cell lung cancer patients.

Authors:  Haijing Zhou; Lin Cai; Xiupeng Zhang; Ailin Li; Yuan Miao; Qingchang Li; Xueshan Qiu; Enhua Wang
Journal:  Lab Invest       Date:  2018-01-30       Impact factor: 5.662

Review 7.  Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease.

Authors:  D R Cook; K L Rossman; C J Der
Journal:  Oncogene       Date:  2013-09-16       Impact factor: 9.867

Review 8.  Targeting Rac and Cdc42 GEFs in Metastatic Cancer.

Authors:  Maria Del Mar Maldonado; Julia Isabel Medina; Luis Velazquez; Suranganie Dharmawardhane
Journal:  Front Cell Dev Biol       Date:  2020-04-08

9.  Comprehensive molecular profiling of lung adenocarcinoma.

Authors: 
Journal:  Nature       Date:  2014-07-09       Impact factor: 49.962

10.  Rac-GEF/Rac Signaling and Metastatic Dissemination in Lung Cancer.

Authors:  Mariana Cooke; Martin J Baker; Marcelo G Kazanietz
Journal:  Front Cell Dev Biol       Date:  2020-02-25
  10 in total

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