Literature DB >> 35419480

SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy.

Kazuhiro Fukumura1, Julian P Venables2, Akila Mayeda1.   

Abstract

The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to various anticancer drugs, SPF45-dependent splicing may play a critical role in multidrug resistance.
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Entities:  

Keywords:  Pre-mRNA splicing; SPF45 (RBM17); U2AF heterodimer; anticancer drug resistance; short intron

Year:  2021        PMID： 35419480      PMCID： PMC8997263          DOI： 10.1080/23723556.2021.1996318

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  14 in total

1.  U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.

Authors:  Lorenzo Corsini; Sophie Bonnal; Sophie Bonna; Jerome Basquin; Michael Hothorn; Klaus Scheffzek; Juan Valcárcel; Michael Sattler
Journal:  Nat Struct Mol Biol       Date:  2007-06-24       Impact factor: 15.369

Review 2.  The spliceosome: design principles of a dynamic RNP machine.

Authors:  Markus C Wahl; Cindy L Will; Reinhard Lührmann
Journal:  Cell       Date:  2009-02-20       Impact factor: 41.582

3.  Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models.

Authors:  Qiumin Tan; Hari Krishna Yalamanchili; Jeehye Park; Antonia De Maio; Hsiang-Chih Lu; Ying-Wooi Wan; Joshua J White; Vitaliy V Bondar; Layal S Sayegh; Xiuyun Liu; Yan Gao; Roy V Sillitoe; Harry T Orr; Zhandong Liu; Huda Y Zoghbi
Journal:  Hum Mol Genet       Date:  2016-12-01       Impact factor: 6.150

4.  Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45.

Authors:  María José Lallena; Kevin J Chalmers; Salud Llamazares; Angus I Lamond; Juan Valcárcel
Journal:  Cell       Date:  2002-05-03       Impact factor: 41.582

5.  MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation.

Authors:  Kyung-Min Lee; Jennifer M Giltnane; Justin M Balko; Luis J Schwarz; Angel L Guerrero-Zotano; Katherine E Hutchinson; Mellissa J Nixon; Mónica V Estrada; Violeta Sánchez; Melinda E Sanders; Taekyu Lee; Henry Gómez; Ana Lluch; J Alejandro Pérez-Fidalgo; Melissa Magdalene Wolf; Gabriela Andrejeva; Jeffrey C Rathmell; Stephen W Fesik; Carlos L Arteaga
Journal:  Cell Metab       Date:  2017-10-03       Impact factor: 27.287

6.  RBM17 controls apoptosis and proliferation to promote Glioma progression.

Authors:  Jianglong Lu; Qun Li; Lin Cai; Zhangzhang Zhu; Jiaqing Guan; Chunyong Wang; Jia Xia; Lei Xia; Min Wen; Weiming Zheng; Zhipeng Su; Chengde Wang
Journal:  Biochem Biophys Res Commun       Date:  2018-09-15       Impact factor: 3.575

7.  Identification and Validation of Evolutionarily Conserved Unusually Short Pre-mRNA Introns in the Human Genome.

Authors:  Makoto K Shimada; Noriko Sasaki-Haraguchi; Akila Mayeda
Journal:  Int J Mol Sci       Date:  2015-05-07       Impact factor: 5.923

8.  Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion.

Authors:  Yuying Liu; LaShardai Conaway; Jennifer Rutherford Bethard; Adnan M Al-Ayoubi; Amber Thompson Bradley; Hui Zheng; Scott A Weed; Scott T Eblen
Journal:  Nucleic Acids Res       Date:  2013-03-21       Impact factor: 16.971

9.  Resistance to anticancer drugs in NIH3T3 cells transfected with c-myc and/or c-H-ras genes.

Authors:  S Niimi; K Nakagawa; J Yokota; Y Tsunokawa; K Nishio; Y Terashima; M Shibuya; M Terada; N Saijo
Journal:  Br J Cancer       Date:  1991-02       Impact factor: 7.640
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