Literature DB >> 35419477

Targeting cancer's sweet spot: UGP2 as a therapeutic vulnerability.

Sunghoon Kim1,2, Andrew Wolfe3,4, Sung Eun Kim1,2.   

Abstract

Understanding the mechanisms governing metabolic reprogramming that underlie potential vulnerabilities in cancer cells is key to developing novel therapeutic strategies. The catalytic enzyme UDP-glucose pyrophosphorylase 2 (UGP2) drives the production of UDP-glucose. Our recent work demonstrated the crucial role of UGP2 in cancer growth and its regulation of cellular metabolic processes.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  UDP-glucose; UGP2; YAP; cancer metabolism; glycosylation

Year:  2021        PMID： 35419477      PMCID： PMC8997258          DOI： 10.1080/23723556.2021.1990676

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Coordinate regulation of sugar flux and translation by PAS kinase.

Authors:  Jared Rutter; Brandon L Probst; Steven L McKnight
Journal:  Cell       Date:  2002-10-04       Impact factor: 41.582

2.  Demonstration, by renaturation in O'Farrell gels, of heterogeneity in Dictyostelium uridine diphosphoglucose pyrophosphorylase.

Authors:  R E Manrow; R P Dottin
Journal:  Anal Biochem       Date:  1982-02       Impact factor: 3.365

3.  Identification of UGP2 as a progression marker that promotes cell growth and motility in human glioma.

Authors:  Chun Zeng; Wenli Xing; Yanhui Liu
Journal:  J Cell Biochem       Date:  2019-02-28       Impact factor: 4.429

4.  Phosphate status affects the gene expression, protein content and enzymatic activity of UDP-glucose pyrophosphorylase in wild-type and pho mutants of Arabidopsis.

Authors:  I Ciereszko; H Johansson; V Hurry; L A Kleczkowski
Journal:  Planta       Date:  2001-03       Impact factor: 4.116

5.  Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation.

Authors:  Xiang Wang; Lingao Ju; Jiadong Fan; Yuan Zhu; Xiaolan Liu; Kun Zhu; Min Wu; Lianyun Li
Journal:  Biochim Biophys Acta       Date:  2014-06-28

6.  Role of N-glycosylation in EGFR ectodomain ligand binding.

Authors:  Maryam Azimzadeh Irani; Srinivasaraghavan Kannan; Chandra Verma
Journal:  Proteins       Date:  2017-05-25

7.  A quaternary mechanism enables the complex biological functions of octameric human UDP-glucose pyrophosphorylase, a key enzyme in cell metabolism.

Authors:  Jana Indra Führing; Johannes Thomas Cramer; Julia Schneider; Petra Baruch; Rita Gerardy-Schahn; Roman Fedorov
Journal:  Sci Rep       Date:  2015-04-10       Impact factor: 4.379

8.  UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth.

Authors:  Andrew L Wolfe; Qingwen Zhou; Eneda Toska; Jacqueline Galeas; Angel A Ku; Richard P Koche; Sourav Bandyopadhyay; Maurizio Scaltriti; Carlito B Lebrilla; Frank McCormick; Sung Eun Kim
Journal:  Proc Natl Acad Sci U S A       Date:  2021-08-03       Impact factor: 12.779

9.  Defects in Galactose Metabolism and Glycoconjugate Biosynthesis in a UDP-Glucose Pyrophosphorylase-Deficient Cell Line Are Reversed by Adding Galactose to the Growth Medium.

Authors:  Christelle Durrant; Jana I Fuehring; Alexandra Willemetz; Dominique Chrétien; Giusy Sala; Riccardo Ghidoni; Abram Katz; Agnès Rötig; Monica Thelestam; Myriam Ermonval; Stuart E H Moore
Journal:  Int J Mol Sci       Date:  2020-03-16       Impact factor: 5.923

10.  Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases.

Authors:  Elena Perenthaler; Anita Nikoncuk; Soheil Yousefi; Woutje M Berdowski; Maysoon Alsagob; Ivan Capo; Herma C van der Linde; Paul van den Berg; Edwin H Jacobs; Darija Putar; Mehrnaz Ghazvini; Eleonora Aronica; Wilfred F J van IJcken; Walter G de Valk; Evita Medici-van den Herik; Marjon van Slegtenhorst; Lauren Brick; Mariya Kozenko; Jennefer N Kohler; Jonathan A Bernstein; Kristin G Monaghan; Amber Begtrup; Rebecca Torene; Amna Al Futaisi; Fathiya Al Murshedi; Renjith Mani; Faisal Al Azri; Erik-Jan Kamsteeg; Majid Mojarrad; Atieh Eslahi; Zaynab Khazaei; Fateme Massinaei Darmiyan; Mohammad Doosti; Ehsan Ghayoor Karimiani; Jana Vandrovcova; Faisal Zafar; Nuzhat Rana; Krishna K Kandaswamy; Jozef Hertecant; Peter Bauer; Mohammed A AlMuhaizea; Mustafa A Salih; Mazhor Aldosary; Rawan Almass; Laila Al-Quait; Wafa Qubbaj; Serdar Coskun; Khaled O Alahmadi; Muddathir H A Hamad; Salem Alwadaee; Khalid Awartani; Anas M Dababo; Futwan Almohanna; Dilek Colak; Mohammadreza Dehghani; Mohammad Yahya Vahidi Mehrjardi; Murat Gunel; A Gulhan Ercan-Sencicek; Gouri Rao Passi; Huma Arshad Cheema; Stephanie Efthymiou; Henry Houlden; Aida M Bertoli-Avella; Alice S Brooks; Kyle Retterer; Reza Maroofian; Namik Kaya; Tjakko J van Ham; Tahsin Stefan Barakat
Journal:  Acta Neuropathol       Date:  2019-12-09       Impact factor: 17.088
  10 in total

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