Literature DB >> 35419473

A therapeutic window for preventive therapy in NF1-associated optic pathway glioma.

Yuan Zhu1,2,3,4, Wang Zheng1,2,3, Emmanuelle S Jecrois1,2,3,4, Brianna R Pierce1,2,3, Daniel M Treisman1,2,3.   

Abstract

Pediatric low-grade gliomas (pLGGs) are almost universally driven by abnormal activation of RAS-mediated MEK-ERK/MAPK signaling pathway. pLGGs predominantly occur in children, suggesting that they originate in an ERK-dependent neural stem/progenitor population(s) transiently present in the developing brain. Our recent preclinical study reveals a cell-lineage-of-origin and develops a chemopreventative therapeutic strategy.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Neurofibromatosis type 1; hypothalamic ventricular zone (hVZ); neural stem cells; pediatric low-grade glioma; radial glia (RG)

Year:  2021        PMID： 35419473      PMCID： PMC8997259          DOI： 10.1080/23723556.2021.1989262

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  MEK Is a Key Regulator of Gliogenesis in the Developing Brain.

Authors:  Xiaoyan Li; Jason M Newbern; Yaohong Wu; Meghan Morgan-Smith; Jian Zhong; Jean Charron; William D Snider
Journal:  Neuron       Date:  2012-09-20       Impact factor: 17.173

2.  Development of astrocytes in the vertebrate eye.

Authors:  Chenqi Tao; Xin Zhang
Journal:  Dev Dyn       Date:  2014-10-13       Impact factor: 3.780

3.  Innate neural stem cell heterogeneity determines the patterning of glioma formation in children.

Authors:  Da Yong Lee; Scott M Gianino; David H Gutmann
Journal:  Cancer Cell       Date:  2012-07-10       Impact factor: 31.743

Review 4.  Neurofibromatosis type 1.

Authors:  David H Gutmann; Rosalie E Ferner; Robert H Listernick; Bruce R Korf; Pamela L Wolters; Kimberly J Johnson
Journal:  Nat Rev Dis Primers       Date:  2017-02-23       Impact factor: 52.329

5.  Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus.

Authors:  Xin Zhou; Suijuan Zhong; Honghai Peng; Jing Liu; Wenyu Ding; Le Sun; Qiang Ma; Zeyuan Liu; Ruiguo Chen; Qian Wu; Xiaoqun Wang
Journal:  Nat Commun       Date:  2020-08-13       Impact factor: 14.919

6.  Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas.

Authors:  Scott Ryall; Michal Zapotocky; Kohei Fukuoka; Liana Nobre; Ana Guerreiro Stucklin; Julie Bennett; Robert Siddaway; Christopher Li; Sanja Pajovic; Anthony Arnoldo; Paul E Kowalski; Monique Johnson; Javal Sheth; Alvaro Lassaletta; Ruth G Tatevossian; Wilda Orisme; Ibrahim Qaddoumi; Lea F Surrey; Marilyn M Li; Angela J Waanders; Stephen Gilheeney; Marc Rosenblum; Tejus Bale; Derek S Tsang; Normand Laperriere; Abhaya Kulkarni; George M Ibrahim; James Drake; Peter Dirks; Michael D Taylor; James T Rutka; Suzanne Laughlin; Manohar Shroff; Mary Shago; Lili-Naz Hazrati; Colleen D'Arcy; Vijay Ramaswamy; Ute Bartels; Annie Huang; Eric Bouffet; Matthias A Karajannis; Mariarita Santi; David W Ellison; Uri Tabori; Cynthia Hawkins
Journal:  Cancer Cell       Date:  2020-04-13       Impact factor: 31.743

7.  ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities.

Authors:  Yuan Wang; Edward Kim; Xiaojing Wang; Bennett G Novitch; Kazuaki Yoshikawa; Long-Sheng Chang; Yuan Zhu
Journal:  Cell       Date:  2012-08-17       Impact factor: 41.582

8.  Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors.

Authors:  Emmanuelle S Jecrois; Wang Zheng; Miriam Bornhorst; Yinghua Li; Daniel M Treisman; Daphine Muguyo; Sharon Huynh; Shayne F Andrew; Yuan Wang; Jingwen Jiang; Brianna R Pierce; Hongmei Mao; Matthew K Krause; Austin Friend; Francisco Nadal-Nicolas; Steven F Stasheff; Wei Li; Hui Zong; Roger J Packer; Yuan Zhu
Journal:  Dev Cell       Date:  2021-08-23       Impact factor: 12.270

9.  OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms.

Authors:  José Javier Otero; David Rowitch; Scott Vandenberg
Journal:  J Neurooncol       Date:  2010-12-31       Impact factor: 4.130

10.  Stalled developmental programs at the root of pediatric brain tumors.

Authors:  Selin Jessa; Alexis Blanchet-Cohen; Brian Krug; Maria Vladoiu; Marie Coutelier; Damien Faury; Brice Poreau; Nicolas De Jay; Steven Hébert; Jean Monlong; W Todd Farmer; Laura K Donovan; Yixing Hu; Melissa K McConechy; Florence M G Cavalli; Leonie G Mikael; Benjamin Ellezam; Maxime Richer; Andréa Allaire; Alexander G Weil; Jeffrey Atkinson; Jean-Pierre Farmer; Roy W R Dudley; Valerie Larouche; Louis Crevier; Steffen Albrecht; Mariella G Filbin; Hervé Sartelet; Pierre-Eric Lutz; Corina Nagy; Gustavo Turecki; Santiago Costantino; Peter B Dirks; Keith K Murai; Guillaume Bourque; Jiannis Ragoussis; Livia Garzia; Michael D Taylor; Nada Jabado; Claudia L Kleinman
Journal:  Nat Genet       Date:  2019-11-25       Impact factor: 38.330
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.