Literature DB >> 35419468

CTCF puts a new twist on UV damage and repair in skin cancer.

Bastian Stark1, Gregory M K Poon2, John J Wyrick1,3.   

Abstract

Somatic mutations in skin cancers are highly enriched at binding sites for CCCTC-binding factor (CTCF). We have discovered that CTCF binding alters the DNA structure to render it more susceptible to UV damage. Elevated UV damage formation at CTCF binding sites, in conjunction with subsequent repair inhibition, promotes UV mutagenesis.
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Entities:  

Keywords:  CCCTC-binding factor; DNA repair; Ultraviolet light; skin cancer; transcription factor

Year:  2021        PMID： 35419468      PMCID： PMC8997251          DOI： 10.1080/23723556.2021.2009424

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Inhibition of transcription factor binding by ultraviolet-induced pyrimidine dimers.

Authors:  S Tommasi; P M Swiderski; Y Tu; B E Kaplan; G P Pfeifer
Journal:  Biochemistry       Date:  1996-12-10       Impact factor: 3.162

Review 2.  Local Determinants of the Mutational Landscape of the Human Genome.

Authors:  Abel Gonzalez-Perez; Radhakrishnan Sabarinathan; Nuria Lopez-Bigas
Journal:  Cell       Date:  2019-03-21       Impact factor: 41.582

3.  Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif.

Authors:  Rebecca C Poulos; Julie A I Thoms; Yi Fang Guan; Ashwin Unnikrishnan; John E Pimanda; Jason W H Wong
Journal:  Cell Rep       Date:  2016-12-13       Impact factor: 9.423

4.  Nucleotide excision repair is impaired by binding of transcription factors to DNA.

Authors:  Radhakrishnan Sabarinathan; Loris Mularoni; Jordi Deu-Pons; Abel Gonzalez-Perez; Núria López-Bigas
Journal:  Nature       Date:  2016-04-14       Impact factor: 49.962

5.  CTCF/cohesin-binding sites are frequently mutated in cancer.

Authors:  Riku Katainen; Kashyap Dave; Esa Pitkänen; Kimmo Palin; Teemu Kivioja; Niko Välimäki; Alexandra E Gylfe; Heikki Ristolainen; Ulrika A Hänninen; Tatiana Cajuso; Johanna Kondelin; Tomas Tanskanen; Jukka-Pekka Mecklin; Heikki Järvinen; Laura Renkonen-Sinisalo; Anna Lepistö; Eevi Kaasinen; Outi Kilpivaara; Sari Tuupanen; Martin Enge; Jussi Taipale; Lauri A Aaltonen
Journal:  Nat Genet       Date:  2015-06-08       Impact factor: 38.330

6.  CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma.

Authors:  Smitha Sivapragasam; Bastian Stark; Amanda V Albrecht; Kaitlynne A Bohm; Peng Mao; Raymond G Emehiser; Steven A Roberts; Patrick J Hrdlicka; Gregory M K Poon; John J Wyrick
Journal:  EMBO J       Date:  2021-09-06       Impact factor: 14.012

7.  Highly recurrent TERT promoter mutations in human melanoma.

Authors:  Franklin W Huang; Eran Hodis; Mary Jue Xu; Gregory V Kryukov; Lynda Chin; Levi A Garraway
Journal:  Science       Date:  2013-01-24       Impact factor: 47.728

Review 8.  Non-coding driver mutations in human cancer.

Authors:  Kerryn Elliott; Erik Larsson
Journal:  Nat Rev Cancer       Date:  2021-07-06       Impact factor: 60.716

Review 9.  CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation.

Authors:  Matthias Merkenschlager; Elphège P Nora
Journal:  Annu Rev Genomics Hum Genet       Date:  2016-04-18       Impact factor: 8.929

10.  ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma.

Authors:  Peng Mao; Alexander J Brown; Shingo Esaki; Svetlana Lockwood; Gregory M K Poon; Michael J Smerdon; Steven A Roberts; John J Wyrick
Journal:  Nat Commun       Date:  2018-07-06       Impact factor: 14.919
  10 in total
  1 in total

1.  Molecular mechanism of UV damage modulation in nucleosomes.

Authors:  Bastian Stark; Gregory M K Poon; John J Wyrick
Journal:  Comput Struct Biotechnol J       Date:  2022-09-14       Impact factor: 6.155
  1 in total

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