Literature DB >> 35419467

Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.

Fabrizio Simeoni1, Tim Cp Somervaille1.   

Abstract

Tissue-inappropriate expression of FOXC1 (Forkhead Box C1) in acute myeloid leukemia confers a monocyte/macrophage lineage differentiation block. We discovered that FOXC1 interacts with RUNX1 (Runt-Related Transcription Factor 1) to stabilize a RUNX1, HDAC1 (Histone Deacetylase 1) and TLE3 (Transducin-like enhancer protein 3) repressor complex at enhancers controlling myeloid differentiation genes.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  AML; FOXC1; Groucho; RUNX1; TLE3

Year:  2021        PMID： 35419467      PMCID： PMC8997249          DOI： 10.1080/23723556.2021.2003161

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions.

Authors:  Tara C Murphy; Ramsey A Saleem; Tim Footz; Robert Ritch; Barbara McGillivray; Michael A Walter
Journal:  Invest Ophthalmol Vis Sci       Date:  2004-08       Impact factor: 4.799

2.  Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation.

Authors:  Yoshiki Omatsu; Masanari Seike; Tatsuki Sugiyama; Tsutomu Kume; Takashi Nagasawa
Journal:  Nature       Date:  2014-03-02       Impact factor: 49.962

3.  Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia.

Authors:  Tim D D Somerville; Daniel H Wiseman; Gary J Spencer; Xu Huang; James T Lynch; Hui Sun Leong; Emma L Williams; Edmund Cheesman; Tim C P Somervaille
Journal:  Cancer Cell       Date:  2015-09-14       Impact factor: 31.743

4.  The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis.

Authors:  T Kume; H Jiang; J M Topczewska; B L Hogan
Journal:  Genes Dev       Date:  2001-09-15       Impact factor: 11.361

5.  Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.

Authors:  Joseph D Growney; Hirokazu Shigematsu; Zhe Li; Benjamin H Lee; Jennifer Adelsperger; Rebecca Rowan; David P Curley; Jeffery L Kutok; Koichi Akashi; Ifor R Williams; Nancy A Speck; D Gary Gilliland
Journal:  Blood       Date:  2005-03-22       Impact factor: 22.113

6.  Mesogenin 1 is a master regulator of paraxial presomitic mesoderm differentiation.

Authors:  Ravindra B Chalamalasetty; Robert J Garriock; William C Dunty; Mark W Kennedy; Parthav Jailwala; Han Si; Terry P Yamaguchi
Journal:  Development       Date:  2014-11       Impact factor: 6.868

7.  Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development.

Authors:  Seungwoon Seo; Lisheng Chen; Wenzhong Liu; Demin Zhao; Kathryn M Schultz; Amy Sasman; Ting Liu; Hao F Zhang; Philip J Gage; Tsutomu Kume
Journal:  Invest Ophthalmol Vis Sci       Date:  2017-03-01       Impact factor: 4.799

Review 8.  The Diverse Consequences of FOXC1 Deregulation in Cancer.

Authors:  L Niall Gilding; Tim C P Somervaille
Journal:  Cancers (Basel)       Date:  2019-02-05       Impact factor: 6.639

9.  Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.

Authors:  Fabrizio Simeoni; Isabel Romero-Camarero; Francesco Camera; Fabio M R Amaral; Oliver J Sinclair; Evangelia K Papachristou; Gary J Spencer; Michael Lie-A-Ling; Georges Lacaud; Daniel H Wiseman; Jason S Carroll; Tim C P Somervaille
Journal:  Cell Rep       Date:  2021-09-21       Impact factor: 9.423

10.  The Groucho/TLE/Grg family of transcriptional co-repressors.

Authors:  Barbara H Jennings; David Ish-Horowicz
Journal:  Genome Biol       Date:  2008-01-31       Impact factor: 13.583
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.