Literature DB >> 3541932

Cachectin/TNF as well as interleukin-1 induces prostacyclin synthesis in cultured vascular endothelial cells.

M Kawakami, S Ishibashi, H Ogawa, T Murase, F Takaku, S Shibata.   

Abstract

Cachectin/tumor necrosis factor (cachectin/TNF) has been shown to be capable of stimulating prostacyclin (PGI2) production by vascular endothelial cells in vitro. The stimulation of PGI2 by cachectin/TNF is comparable to that observed with interleukin-1, the monokine previously suggested to be the principal mediator of this effect. The ability of cachectin/TNF to stimulate PGI2 production suggests that it may play a role in producing depressed blood pressure or shock. If so, it might be possible to prevent such adverse effects with the aid of anti-inflammatory agents.

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Year:  1986        PMID： 3541932     DOI： 10.1016/s0006-291x(86)80198-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  22 in total

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3.  Tumor necrosis factor induces glomerular damage in the rabbit.

Authors:  T Bertani; M Abbate; C Zoja; D Corna; N Perico; P Ghezzi; G Remuzzi
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4.  Primed stimulation of isolated perfused rabbit lung by endotoxin and platelet activating factor induces enhanced production of thromboxane and lung injury.

Authors:  W L Salzer; C E McCall
Journal:  J Clin Invest       Date:  1990-04       Impact factor: 14.808

5.  Retinal expression, regulation, and functional bioactivity of prostacyclin-stimulating factor.

Authors:  Y Hata; A Clermont; T Yamauchi; E A Pierce; I Suzuma; H Kagokawa; H Yoshikawa; G S Robinson; T Ishibashi; T Hashimoto; F Umeda; S E Bursell; L P Aiello
Journal:  J Clin Invest       Date:  2000-08       Impact factor: 14.808

6.  Activated endothelial cells elicit paracrine induction of epithelial chloride secretion. 6-Keto-PGF1alpha is an epithelial secretagogue.

Authors:  E D Blume; C T Taylor; P F Lennon; G L Stahl; S P Colgan
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7.  Interleukin 1 promotes tumor cell adhesion to cultured human endothelial cells.

Authors:  E Dejana; F Bertocchi; M C Bortolami; A Regonesi; A Tonta; F Breviario; R Giavazzi
Journal:  J Clin Invest       Date:  1988-10       Impact factor: 14.808

8.  Requirements for tumor necrosis factor-alpha and interleukin-1 in limb ischemia/reperfusion injury and associated lung injury.

Authors:  A Seekamp; J S Warren; D G Remick; G O Till; P A Ward
Journal:  Am J Pathol       Date:  1993-08       Impact factor: 4.307

9.  Synthesis and release of platelet-activating factor and eicosanoids in human endothelial cells induced by different agonists.

Authors:  F Cabré; D Tost; N Suesa; M Gutiérrez; P Ucedo; D Mauleón; G Carganico
Journal:  Agents Actions       Date:  1993-03

10.  Evaluation of plasma alpha-2-macroglobulin and interactions with tumour necrosis factor-alpha in horses with endotoxemic signs.

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Journal:  Can J Vet Res       Date:  1996-04       Impact factor: 1.310
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