| Literature DB >> 3541921 |
G W Taylor, C G Chappell, C E Frazer, J M Ritter.
Abstract
Prostacyclin (PGI2) synthesis in vascular tissue is stimulated by free Ca2+. Concentrations in excess of 4 mM result in a sustained release of PGI2, but not other prostanoids, from rat aorta. This effect arises by increased synthesis of PGI2 and not through the inhibition of its metabolism. Physico-chemical examination of serum and plasma extract has indicated that much of the PGI2-stimulating activity reported for human serum derives from the presence of free Ca2+.Entities:
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Year: 1986 PMID： 3541921 PMCID： PMC1147267 DOI： 10.1042/bj2390237
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857