Literature DB >> 35418220

PEN2: Metformin's new partner at lysosome.

Kei Sakamoto1, Niels Jessen2.   

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Year:  2022        PMID： 35418220      PMCID： PMC9160082          DOI： 10.1038/s41422-022-00661-7

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   46.297


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  13 in total

1.  Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice.

Authors:  A Maida; B J Lamont; X Cao; D J Drucker
Journal:  Diabetologia       Date:  2010-10-23       Impact factor: 10.122

2.  Metformin Activates AMPK through the Lysosomal Pathway.

Authors:  Chen-Song Zhang; Mengqi Li; Teng Ma; Yue Zong; Jiwen Cui; Jin-Wei Feng; Yu-Qing Wu; Shu-Yong Lin; Sheng-Cai Lin
Journal:  Cell Metab       Date:  2016-10-11       Impact factor: 27.287

Review 3.  Metformin Biodistribution: A Key to Mechanisms of Action?

Authors:  Elias Sundelin; Jonas Brorson Jensen; Steen Jakobsen; Lars C Gormsen; Niels Jessen
Journal:  J Clin Endocrinol Metab       Date:  2020-11-01       Impact factor: 5.958

Review 4.  Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus.

Authors:  Marc Foretz; Bruno Guigas; Benoit Viollet
Journal:  Nat Rev Endocrinol       Date:  2019-08-22       Impact factor: 43.330

Review 5.  AMP-activated protein kinase: the current landscape for drug development.

Authors:  Gregory R Steinberg; David Carling
Journal:  Nat Rev Drug Discov       Date:  2019-07       Impact factor: 84.694

6.  Low-dose metformin targets the lysosomal AMPK pathway through PEN2.

Authors:  Teng Ma; Xiao Tian; Baoding Zhang; Mengqi Li; Yu Wang; Chunyan Yang; Jianfeng Wu; Xiaoyan Wei; Qi Qu; Yaxin Yu; Shating Long; Jin-Wei Feng; Chun Li; Cixiong Zhang; Changchuan Xie; Yaying Wu; Zheni Xu; Junjie Chen; Yong Yu; Xi Huang; Ying He; Luming Yao; Lei Zhang; Mingxia Zhu; Wen Wang; Zhi-Chao Wang; Mingliang Zhang; Yuqian Bao; Weiping Jia; Shu-Yong Lin; Zhiyun Ye; Hai-Long Piao; Xianming Deng; Chen-Song Zhang; Sheng-Cai Lin
Journal:  Nature       Date:  2022-02-23       Impact factor: 69.504

Review 7.  Structure-activity relationship of presenilin in γ-secretase-mediated intramembrane cleavage.

Authors:  Tetsuo Cai; Taisuke Tomita
Journal:  Semin Cell Dev Biol       Date:  2020-03-11       Impact factor: 7.727

8.  Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis.

Authors:  Séverine Olivier; Camille Pochard; Hanna Diounou; Vanessa Castillo; Jordane Divoux; Joshua Alcantara; Jocelyne Leclerc; Sandra Guilmeau; Camille Huet; Wafa Charifi; Thibault V Varin; Noëmie Daniel; Marc Foretz; Michel Neunlist; Benoit L Salomon; Pradipta Ghosh; André Marette; Malvyne Rolli-Derkinderen; Benoit Viollet
Journal:  Mol Metab       Date:  2021-02-04       Impact factor: 7.422

9.  Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

Authors:  Morgan D Fullerton; Sandra Galic; Katarina Marcinko; Sarah Sikkema; Thomas Pulinilkunnil; Zhi-Ping Chen; Hayley M O'Neill; Rebecca J Ford; Rengasamy Palanivel; Matthew O'Brien; D Grahame Hardie; S Lance Macaulay; Jonathan D Schertzer; Jason R B Dyck; Bryce J van Denderen; Bruce E Kemp; Gregory R Steinberg
Journal:  Nat Med       Date:  2013-11-03       Impact factor: 53.440

Review 10.  Cellular and Molecular Mechanisms of Metformin Action.

Authors:  Traci E LaMoia; Gerald I Shulman
Journal:  Endocr Rev       Date:  2021-01-28       Impact factor: 19.871
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