Literature DB >> 35416931

An unexpected role for PD-L1 in front-rear polarization and directional migration.

Miguel Sánchez-Álvarez1, Miguel A Del Pozo1.   

Abstract

Programmed cell death-ligand 1 (PD-L1)-mediated T cell inhibition through PD-1 is a key checkpoint frequently exploited by tumors to evade immunity. In this issue, Wang et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108083) reveal an unexpected role for PD-L1 in promoting tumor cell front-rear polarity and directionally persistent cell migration, independently of PD-1.
© 2022 Sánchez-Álvarez and del Pozo.

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Year:  2022        PMID： 35416931      PMCID： PMC9011200          DOI： 10.1083/jcb.202203137

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   10.539


  6 in total

Review 1.  Caveolae as plasma membrane sensors, protectors and organizers.

Authors:  Robert G Parton; Miguel A del Pozo
Journal:  Nat Rev Mol Cell Biol       Date:  2013-02       Impact factor: 94.444

2.  Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.

Authors:  Haidong Dong; Scott E Strome; Diva R Salomao; Hideto Tamura; Fumiya Hirano; Dallas B Flies; Patrick C Roche; Jun Lu; Gefeng Zhu; Koji Tamada; Vanda A Lennon; Esteban Celis; Lieping Chen
Journal:  Nat Med       Date:  2002-06-24       Impact factor: 53.440

Review 3.  Paradigms on Immunotherapy Combinations with Chemotherapy.

Authors:  Miguel F Sanmamed; Ignacio Melero; Diego Salas-Benito; José L Pérez-Gracia; Mariano Ponz-Sarvisé; María E Rodriguez-Ruiz; Iván Martínez-Forero; Eduardo Castañón; José M López-Picazo
Journal:  Cancer Discov       Date:  2021-03-12       Impact factor: 39.397

4.  PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells.

Authors:  Katarzyna Karwacz; Christopher Bricogne; Douglas MacDonald; Frederick Arce; Clare L Bennett; Mary Collins; David Escors
Journal:  EMBO Mol Med       Date:  2011-08-10       Impact factor: 12.137

5.  Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration.

Authors:  Joseph H R Hetmanski; Henry de Belly; Ignacio Busnelli; Thomas Waring; Roshna V Nair; Vanesa Sokleva; Oana Dobre; Angus Cameron; Nils Gauthier; Christophe Lamaze; Joe Swift; Aránzazu Del Campo; Tobias Starborg; Tobias Zech; Jacky G Goetz; Ewa K Paluch; Jean-Marc Schwartz; Patrick T Caswell
Journal:  Dev Cell       Date:  2019-10-10       Impact factor: 12.270

6.  Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases.

Authors:  Araceli Grande-García; Asier Echarri; Johan de Rooij; Nazilla B Alderson; Clare M Waterman-Storer; José M Valdivielso; Miguel A del Pozo
Journal:  J Cell Biol       Date:  2007-05-21       Impact factor: 10.539
  6 in total

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