Xiaolin Wei1,2, Ruzhen Yuan2,3, Juan Yang4, Wei Zheng5, Yongmei Jin6, Mingyue Wang2, Jieting Jiang2, Caiqin Wu7, Kunpeng Li8. 1. Department of Gynaecology, Obstetrics and Gynaecology Hospital, Fudan University, Shanghai, China. 2. School of Nursing, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China. 3. Department of Nursing, East Hospital Affiliated to Tongji University, Shanghai, China. 4. Department of Breast Surgery, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. 5. Department of Breast Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. 6. Department of Nursing, the Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. 7. School of Nursing, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China. yuwuchina@aliyun.com. 8. School of Rehabilitation Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China. 312523418@qq.com.
Abstract
PURPOSE: Cognitive decline is one of the main side effects of breast cancer patients after relevant treatment, but there is a lack of clear measures for prevention and management without definite mechanism. Moreover, postoperative patients also have a need for limb rehabilitation. Whether the cognitive benefits of Baduanjin exercise can improve the overall well-being of breast cancer patients remains unknown. METHODS: This randomized controlled trial was conducted on 70 patients with breast cancer receiving chemotherapy who were randomly assigned and allocated to (1:1) a supervised Baduanjin intervention group (5 times/week, 30 min each time) or a control group for 3 months. The effects of Baduanjin exercise intervention were evaluated by outcome measures including subjective cognitive function, symptoms (fatigue, depression, and anxiety), and health-related quality of life at pre-intervention (T0), 4 weeks (T1), 8 weeks (T2), and 12 weeks (T3). The collected data were analyzed by using an intention-to-treat principle and linear mixed-effects modeling. RESULTS: Participants in the Baduanjin intervention group had a significantly greater improvement in terms of FACT-Cog (F = 14.511; p < 0.001), PCI (F = 15.789; p < 0.001), PCA (F = 6.261; p = 0.015), and FACT-B scores (F = 8.900; p = 0.004) compared with the control group over the time. The exercise-cognition relationship was significantly mediated through the reduction of fatigue (indirect effect: β = 0.132; 95% CI 0.046 to 0.237) and the improvement of anxiety (indirect effect: β = - 0.075; 95% CI - 0.165 to -0.004). CONCLUSIONS: This pilot study revealed the benefits of Baduanjin exercise for subjective cognition and health-related quality of life of Chinese breast cancer patients receiving chemotherapy and outlined the underlying mediating mechanism of exercise-cognition. The findings provided insights into the development of public health initiatives to promote brain health and improve quality of life among breast cancer patients. TRIAL REGISTRATION NUMBER: ChiCTR 2,000,033,152.
PURPOSE: Cognitive decline is one of the main side effects of breast cancer patients after relevant treatment, but there is a lack of clear measures for prevention and management without definite mechanism. Moreover, postoperative patients also have a need for limb rehabilitation. Whether the cognitive benefits of Baduanjin exercise can improve the overall well-being of breast cancer patients remains unknown. METHODS: This randomized controlled trial was conducted on 70 patients with breast cancer receiving chemotherapy who were randomly assigned and allocated to (1:1) a supervised Baduanjin intervention group (5 times/week, 30 min each time) or a control group for 3 months. The effects of Baduanjin exercise intervention were evaluated by outcome measures including subjective cognitive function, symptoms (fatigue, depression, and anxiety), and health-related quality of life at pre-intervention (T0), 4 weeks (T1), 8 weeks (T2), and 12 weeks (T3). The collected data were analyzed by using an intention-to-treat principle and linear mixed-effects modeling. RESULTS: Participants in the Baduanjin intervention group had a significantly greater improvement in terms of FACT-Cog (F = 14.511; p < 0.001), PCI (F = 15.789; p < 0.001), PCA (F = 6.261; p = 0.015), and FACT-B scores (F = 8.900; p = 0.004) compared with the control group over the time. The exercise-cognition relationship was significantly mediated through the reduction of fatigue (indirect effect: β = 0.132; 95% CI 0.046 to 0.237) and the improvement of anxiety (indirect effect: β = - 0.075; 95% CI - 0.165 to -0.004). CONCLUSIONS: This pilot study revealed the benefits of Baduanjin exercise for subjective cognition and health-related quality of life of Chinese breast cancer patients receiving chemotherapy and outlined the underlying mediating mechanism of exercise-cognition. The findings provided insights into the development of public health initiatives to promote brain health and improve quality of life among breast cancer patients. TRIAL REGISTRATION NUMBER: ChiCTR 2,000,033,152.
Authors: Brandon L Pierce; Rachel Ballard-Barbash; Leslie Bernstein; Richard N Baumgartner; Marian L Neuhouser; Mark H Wener; Kathy B Baumgartner; Frank D Gilliland; Bess E Sorensen; Anne McTiernan; Cornelia M Ulrich Journal: J Clin Oncol Date: 2009-05-26 Impact factor: 44.544
Authors: John E Schmidt; Ellen Beckjord; Dana H Bovbjerg; Carissa A Low; Donna M Posluszny; Amy E Lowery; Mary Amanda Dew; Stephanie Nutt; Sarah R Arvey; Ruth Rechis Journal: J Cancer Surviv Date: 2015-08-04 Impact factor: 4.442
Authors: Florence Joly; Bénédicte Giffard; Olivier Rigal; Michiel B De Ruiter; Brent J Small; Martine Dubois; Johan LeFel; Sanne B Schagen; Tim A Ahles; Jeffrey S Wefel; Janette L Vardy; Véronique Pancré; Marie Lange; Hélène Castel Journal: J Pain Symptom Manage Date: 2015-09-05 Impact factor: 3.612
Authors: Tim A Ahles; Andrew J Saykin; Brenna C McDonald; Yuelin Li; Charlotte T Furstenberg; Brett S Hanscom; Tamsin J Mulrooney; Gary N Schwartz; Peter A Kaufman Journal: J Clin Oncol Date: 2010-09-13 Impact factor: 44.544
Authors: Y T Cheung; T Ng; M Shwe; H K Ho; K M Foo; M T Cham; J A Lee; G Fan; Y P Tan; W S Yong; P Madhukumar; S K Loo; S F Ang; M Wong; W Y Chay; W S Ooi; R A Dent; Y S Yap; R Ng; A Chan Journal: Ann Oncol Date: 2015-04-28 Impact factor: 32.976