Tomoyasu Takemura1, Yuki Kataoka2,3,4,5, Nanami Ashi6, Chigusa Shirakawa7, Koya Okazaki6, Azusa Sakurai8, Takuma Imakita9, Shunkichi Ikegaki6, Hirotaka Matsumoto6, Emiko Saito6, Hirohito Takata6, Sawako Kaku10, Nobuko Wada6, Mariko Shinomiya6, Takehiro Otoshi11, Masatoshi Shimada12, Junichi Nikaido6, Reika Iki6, Katsuya Hirano6, Tomoyuki Hirai6, Kazuo Endo6, Masataka Hirabayashi6, Toru Naganuma13,14. 1. Department of Internal Medicine, Kyoto Min-Iren Chuo Hospital, Uzumasa Tsuchimotocho, 2-1, Ukyo, Kyoto, 616-8147, Japan. tomoyasutakemura@yahoo.co.jp. 2. Section of Clinical Epidemiology, Department of Community Medicine, Kyoto University Graduate School of Medicine, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan. 3. Department of Healthcare Epidemiology, Kyoto University Graduate School of Medicine/Public Health, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan. 4. Systematic Review Workshop Peer Support Group (SRWS-PSG), Osaka, Japan. 5. Department of Internal Medicine, Kyoto Min-Iren Asukai Hospital, 89 Tanaka-asukaicho Sakyo, Kyoto, Japan. 6. Department of Respiratory Medicine, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Hyogo, Japan. 7. Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan. 8. Department of Gynecology, Kyoto University Hospital, Kyoto, Japan. 9. Division of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan. 10. Department of Diagnostic Radiology, National Cancer Center Hospital, Chuo, Tokyo, Japan. 11. Division of Respiratory Medicine/Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. 12. Division of Internal Medicine, Miyaji Hospital, Kobe, Hyogo, Japan. 13. Futaba Emergency and General Medicine Support Center, Fukushima Medical University, Fukushima, Japan. 14. Department of General Internal Medicine, Fukushima Medical University, Fukushima, Japan.
Abstract
PURPOSE: The purpose of this study was to investigate the impact of social isolation and loneliness on the overall survival and death at home in patients with lung cancer. METHODS: This prospective cohort study was conducted in a Japanese tertiary hospital. The enrollment period was from April 2018 to March 2020. Patients with pathologically diagnosed advanced lung cancer were included in this study. The primary outcome was overall survival, whereas the secondary outcome was death at home. The exposures were social isolation and loneliness. RESULTS: A total of 211 patients were enrolled and divided into two groups and further into quartiles according to their social isolation and loneliness level, respectively. The hazard ratios of social isolation were 1.65 (95% confidence interval; 1.12 to 2.44) and 1.87 (95% confidence interval; 1.15 to 3.03) in the univariate analysis, while 1.40 (95% confidence interval; 0.92 to 2.13) in the multivariate analysis with complete case and multiple imputation. The odds ratio of death at home with social isolation was 3.47 (95% confidence interval; 1.08 to 11.1) in the multivariate analysis with multiple imputation. Loneliness was not associated with overall survival or death at home. CONCLUSIONS: Our study suggests that social isolation may be related to overall survival and death at home among patients with advanced lung cancer. More attention should be given to such patients at the time of diagnosis.
PURPOSE: The purpose of this study was to investigate the impact of social isolation and loneliness on the overall survival and death at home in patients with lung cancer. METHODS: This prospective cohort study was conducted in a Japanese tertiary hospital. The enrollment period was from April 2018 to March 2020. Patients with pathologically diagnosed advanced lung cancer were included in this study. The primary outcome was overall survival, whereas the secondary outcome was death at home. The exposures were social isolation and loneliness. RESULTS: A total of 211 patients were enrolled and divided into two groups and further into quartiles according to their social isolation and loneliness level, respectively. The hazard ratios of social isolation were 1.65 (95% confidence interval; 1.12 to 2.44) and 1.87 (95% confidence interval; 1.15 to 3.03) in the univariate analysis, while 1.40 (95% confidence interval; 0.92 to 2.13) in the multivariate analysis with complete case and multiple imputation. The odds ratio of death at home with social isolation was 3.47 (95% confidence interval; 1.08 to 11.1) in the multivariate analysis with multiple imputation. Loneliness was not associated with overall survival or death at home. CONCLUSIONS: Our study suggests that social isolation may be related to overall survival and death at home among patients with advanced lung cancer. More attention should be given to such patients at the time of diagnosis.
Authors: Alberto Alonso-Babarro; Eduardo Bruera; María Varela-Cerdeira; María Jesús Boya-Cristia; Rosario Madero; Isabel Torres-Vigil; Javier De Castro; Manuel González-Barón Journal: J Clin Oncol Date: 2011-02-22 Impact factor: 44.544
Authors: Steven J Kittner; Padmini Sekar; Mary E Comeau; Christopher D Anderson; Gunjan Y Parikh; Tachira Tavarez; Matthew L Flaherty; Fernando D Testai; Michael R Frankel; Michael L James; Gene Sung; Mitchell S V Elkind; Bradford B Worrall; Chelsea S Kidwell; Nicole R Gonzales; Sebastian Koch; Christiana E Hall; Lee Birnbaum; Douglas Mayson; Bruce Coull; Marc D Malkoff; Kevin N Sheth; Jacob L McCauley; Jennifer Osborne; Misty Morgan; Lee A Gilkerson; Tyler P Behymer; Stacie L Demel; Charles J Moomaw; Jonathan Rosand; Carl D Langefeld; Daniel Woo Journal: JAMA Netw Open Date: 2021-08-02